Outcomes of split versus reduced-size grafts in pediatric liver transplantation
Background: Split‐liver transplantation, where two grafts are created from a single donor organ, is a means of overcoming donor organ scarcity. There are few data comparing outcomes of split with reduced‐size liver grafts, which is the most common type of cadaveric graft in pediatric liver transpla...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2005-12, Vol.20 (12), p.1850-1854 |
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| creator | OSWARI, HANIFAH LYNCH, STEPHEN V FAWCETT, JONATHAN STRONG, RUSSELL W EE, LOOI C |
| description | Background: Split‐liver transplantation, where two grafts are created from a single donor organ, is a means of overcoming donor organ scarcity. There are few data comparing outcomes of split with reduced‐size liver grafts, which is the most common type of cadaveric graft in pediatric liver transplantation. The aims of the present paper were to compare survival and complication rates between split and reduced‐size cadaveric grafts in pediatric patients receiving a liver transplant in Brisbane.
Methods: Review of the Queensland Liver Transplant Service database was undertaken. All pediatric patients who received either a cadaveric split or reduced‐size graft between 1985 and 2000 were examined. The incidence of patient and graft survival, vascular complications and biliary complications were identified.
Results: A total of 251 liver transplants were performed of which 138 were reduced‐size grafts and 30 were split grafts. There were no differences in etiology of liver disease, mean age, weight, and urgency of transplant between the two groups. One‐year patient and graft survivals were comparable at 73% and 67%, respectively, in both groups. There was no difference in the incidence of vascular complications between groups. Biliary complications were significantly more common after split grafts when compared with reduced‐size grafts (21%vs 4%, P |
| doi_str_mv | 10.1111/j.1440-1746.2005.03926.x |
| format | Article |
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Methods: Review of the Queensland Liver Transplant Service database was undertaken. All pediatric patients who received either a cadaveric split or reduced‐size graft between 1985 and 2000 were examined. The incidence of patient and graft survival, vascular complications and biliary complications were identified.
Results: A total of 251 liver transplants were performed of which 138 were reduced‐size grafts and 30 were split grafts. There were no differences in etiology of liver disease, mean age, weight, and urgency of transplant between the two groups. One‐year patient and graft survivals were comparable at 73% and 67%, respectively, in both groups. There was no difference in the incidence of vascular complications between groups. Biliary complications were significantly more common after split grafts when compared with reduced‐size grafts (21%vs 4%, P < 0.0001) but did not affect patient or graft survival.
Conclusions: Survival and vascular complications after split‐liver grafts were comparable to outcomes after reduced‐size grafts. Biliary complications occur more commonly with split‐liver grafts but did not affect patient or graft survival. It is recommended that every pediatric recipient be considered for a split‐liver graft.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/j.1440-1746.2005.03926.x</identifier><identifier>PMID: 16336443</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Biological and medical sciences ; Cadaver ; Chi-Square Distribution ; Child ; Child, Preschool ; Gastroenterology. Liver. Pancreas. Abdomen ; Graft Rejection ; Graft Survival ; Humans ; liver transplant ; Liver Transplantation - methods ; Liver Transplantation - mortality ; Liver, biliary tract, pancreas, portal circulation, spleen ; Medical sciences ; outcomes ; pediatrics ; Postoperative Complications - epidemiology ; Queensland - epidemiology ; split-liver graft ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Survival Analysis ; Treatment Outcome</subject><ispartof>Journal of gastroenterology and hepatology, 2005-12, Vol.20 (12), p.1850-1854</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4356-8aa3cfae2131590064a2c5bb6c619e89c48da3efbe66c7cc8cf8cb41a48cc50b3</citedby><cites>FETCH-LOGICAL-c4356-8aa3cfae2131590064a2c5bb6c619e89c48da3efbe66c7cc8cf8cb41a48cc50b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1746.2005.03926.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1746.2005.03926.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17312433$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16336443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OSWARI, HANIFAH</creatorcontrib><creatorcontrib>LYNCH, STEPHEN V</creatorcontrib><creatorcontrib>FAWCETT, JONATHAN</creatorcontrib><creatorcontrib>STRONG, RUSSELL W</creatorcontrib><creatorcontrib>EE, LOOI C</creatorcontrib><title>Outcomes of split versus reduced-size grafts in pediatric liver transplantation</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background: Split‐liver transplantation, where two grafts are created from a single donor organ, is a means of overcoming donor organ scarcity. There are few data comparing outcomes of split with reduced‐size liver grafts, which is the most common type of cadaveric graft in pediatric liver transplantation. The aims of the present paper were to compare survival and complication rates between split and reduced‐size cadaveric grafts in pediatric patients receiving a liver transplant in Brisbane.
Methods: Review of the Queensland Liver Transplant Service database was undertaken. All pediatric patients who received either a cadaveric split or reduced‐size graft between 1985 and 2000 were examined. The incidence of patient and graft survival, vascular complications and biliary complications were identified.
Results: A total of 251 liver transplants were performed of which 138 were reduced‐size grafts and 30 were split grafts. There were no differences in etiology of liver disease, mean age, weight, and urgency of transplant between the two groups. One‐year patient and graft survivals were comparable at 73% and 67%, respectively, in both groups. There was no difference in the incidence of vascular complications between groups. Biliary complications were significantly more common after split grafts when compared with reduced‐size grafts (21%vs 4%, P < 0.0001) but did not affect patient or graft survival.
Conclusions: Survival and vascular complications after split‐liver grafts were comparable to outcomes after reduced‐size grafts. Biliary complications occur more commonly with split‐liver grafts but did not affect patient or graft survival. It is recommended that every pediatric recipient be considered for a split‐liver graft.</description><subject>Biological and medical sciences</subject><subject>Cadaver</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Graft Rejection</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>liver transplant</subject><subject>Liver Transplantation - methods</subject><subject>Liver Transplantation - mortality</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Medical sciences</subject><subject>outcomes</subject><subject>pediatrics</subject><subject>Postoperative Complications - epidemiology</subject><subject>Queensland - epidemiology</subject><subject>split-liver graft</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFv0zAYQC0E2srYX0C-wC2ZHTuOc-CAJmhh3SokYNws58sX5JI2xXag26_HodV2nS-25PfsT48QylnO07pY51xKlvFKqrxgrMyZqAuV75-R2cPFczJjmpdZLXh9Sl6GsGaMSVaVJ-SUKyGUlGJGVqsxwrDBQIeOhl3vIv2DPoyBemxHwDYL7h7pT2-7GKjb0h22zkbvgPYukTR6u02e3UYb3bB9RV50tg94ftzPyLePH75eLrLlav7p8v0yAylKlWlrBXQWCy54WTOmpC2gbBoFiteoa5C6tQK7BpWCCkBDp6GR3EoNULJGnJG3h3d3fvg9Yohm4wJgnwbBYQxGaa0rwWUC9QEEP4TgsTM77zbW3xnOzBTTrM3UzEzNzBTT_I9p9kl9ffxjbDbYPorHegl4cwRsANt3KQW48MilAYqEJe7dgfvrerx78gDm83wxnZKfHXwXIu4ffOt_GVWJqjS3N3OzvP1y_f1q8cNU4h-RLKDG</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>OSWARI, HANIFAH</creator><creator>LYNCH, STEPHEN V</creator><creator>FAWCETT, JONATHAN</creator><creator>STRONG, RUSSELL W</creator><creator>EE, LOOI C</creator><general>Blackwell Science Pty</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200512</creationdate><title>Outcomes of split versus reduced-size grafts in pediatric liver transplantation</title><author>OSWARI, HANIFAH ; LYNCH, STEPHEN V ; FAWCETT, JONATHAN ; STRONG, RUSSELL W ; EE, LOOI C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4356-8aa3cfae2131590064a2c5bb6c619e89c48da3efbe66c7cc8cf8cb41a48cc50b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Cadaver</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Graft Rejection</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>liver transplant</topic><topic>Liver Transplantation - methods</topic><topic>Liver Transplantation - mortality</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Medical sciences</topic><topic>outcomes</topic><topic>pediatrics</topic><topic>Postoperative Complications - epidemiology</topic><topic>Queensland - epidemiology</topic><topic>split-liver graft</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OSWARI, HANIFAH</creatorcontrib><creatorcontrib>LYNCH, STEPHEN V</creatorcontrib><creatorcontrib>FAWCETT, JONATHAN</creatorcontrib><creatorcontrib>STRONG, RUSSELL W</creatorcontrib><creatorcontrib>EE, LOOI C</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OSWARI, HANIFAH</au><au>LYNCH, STEPHEN V</au><au>FAWCETT, JONATHAN</au><au>STRONG, RUSSELL W</au><au>EE, LOOI C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes of split versus reduced-size grafts in pediatric liver transplantation</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2005-12</date><risdate>2005</risdate><volume>20</volume><issue>12</issue><spage>1850</spage><epage>1854</epage><pages>1850-1854</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background: Split‐liver transplantation, where two grafts are created from a single donor organ, is a means of overcoming donor organ scarcity. There are few data comparing outcomes of split with reduced‐size liver grafts, which is the most common type of cadaveric graft in pediatric liver transplantation. The aims of the present paper were to compare survival and complication rates between split and reduced‐size cadaveric grafts in pediatric patients receiving a liver transplant in Brisbane.
Methods: Review of the Queensland Liver Transplant Service database was undertaken. All pediatric patients who received either a cadaveric split or reduced‐size graft between 1985 and 2000 were examined. The incidence of patient and graft survival, vascular complications and biliary complications were identified.
Results: A total of 251 liver transplants were performed of which 138 were reduced‐size grafts and 30 were split grafts. There were no differences in etiology of liver disease, mean age, weight, and urgency of transplant between the two groups. One‐year patient and graft survivals were comparable at 73% and 67%, respectively, in both groups. There was no difference in the incidence of vascular complications between groups. Biliary complications were significantly more common after split grafts when compared with reduced‐size grafts (21%vs 4%, P < 0.0001) but did not affect patient or graft survival.
Conclusions: Survival and vascular complications after split‐liver grafts were comparable to outcomes after reduced‐size grafts. Biliary complications occur more commonly with split‐liver grafts but did not affect patient or graft survival. It is recommended that every pediatric recipient be considered for a split‐liver graft.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>16336443</pmid><doi>10.1111/j.1440-1746.2005.03926.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Biological and medical sciences Cadaver Chi-Square Distribution Child Child, Preschool Gastroenterology. Liver. Pancreas. Abdomen Graft Rejection Graft Survival Humans liver transplant Liver Transplantation - methods Liver Transplantation - mortality Liver, biliary tract, pancreas, portal circulation, spleen Medical sciences outcomes pediatrics Postoperative Complications - epidemiology Queensland - epidemiology split-liver graft Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Survival Analysis Treatment Outcome |
| title | Outcomes of split versus reduced-size grafts in pediatric liver transplantation |
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