Target-controlled infusion of propofol in dogs – evaluation of four targets for induction of anaesthesia
Four groups of 20 dogs were anaesthetised by means of target-controlled infusions of propofol designed to achieve 2·5 µg/ml, 3·0 µg/ml, 3·5 µg/ml or 4·0 µg/ml of propofol in blood. The dogs’ pulse rate and respiratory rate were recorded before premedication and induction, immediately after endotrach...
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| Veröffentlicht in: | Veterinary record 2005-12, Vol.157 (24), p.766-770 |
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| creator | Musk, G. C. Pang, D. S. J. Beths, T. Flaherty, D. A. |
| description | Four groups of 20 dogs were anaesthetised by means of target-controlled infusions of propofol designed to achieve 2·5 µg/ml, 3·0 µg/ml, 3·5 µg/ml or 4·0 µg/ml of propofol in blood. The dogs’ pulse rate and respiratory rate were recorded before premedication and induction, immediately after endotracheal intubation and three and five minutes later (times 0, 3 and 5, respectively), and their arterial blood pressure was recorded oscillometrically just before induction and at times 0, 3 and 5. The targets of 2·5, 3·0, 3·5 and 4·0 µg/ml resulted in the successful induction of anaesthesia in 13 (65 per cent), 16 (80 per cent), 20 (100 per cent) and 20 (100 per cent) of the dogs, respectively. The incidence of postinduction apnoea was 0 (0 per cent), one (5 per cent), two (10 per cent) and eight (40 per cent) at time 5 for groups 2·5, 3·0, 3·5 and 4·0 µg/ml, respectively, and its incidence at time 5 was significantly higher in the 4·0 µg/ml group (P |
| doi_str_mv | 10.1136/vr.157.24.766 |
| format | Article |
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C. ; Pang, D. S. J. ; Beths, T. ; Flaherty, D. A.</creator><creatorcontrib>Musk, G. C. ; Pang, D. S. J. ; Beths, T. ; Flaherty, D. A.</creatorcontrib><description>Four groups of 20 dogs were anaesthetised by means of target-controlled infusions of propofol designed to achieve 2·5 µg/ml, 3·0 µg/ml, 3·5 µg/ml or 4·0 µg/ml of propofol in blood. The dogs’ pulse rate and respiratory rate were recorded before premedication and induction, immediately after endotracheal intubation and three and five minutes later (times 0, 3 and 5, respectively), and their arterial blood pressure was recorded oscillometrically just before induction and at times 0, 3 and 5. The targets of 2·5, 3·0, 3·5 and 4·0 µg/ml resulted in the successful induction of anaesthesia in 13 (65 per cent), 16 (80 per cent), 20 (100 per cent) and 20 (100 per cent) of the dogs, respectively. The incidence of postinduction apnoea was 0 (0 per cent), one (5 per cent), two (10 per cent) and eight (40 per cent) at time 5 for groups 2·5, 3·0, 3·5 and 4·0 µg/ml, respectively, and its incidence at time 5 was significantly higher in the 4·0 µg/ml group (P<0·05) than in the other groups. In all the groups there was a significant (P<0·05) decrease in blood pressure between just before induction and the later measurements. Although there were no statistically significant differences between the groups in terms of inducing anaesthesia at a specific target, a target of 3·5 µg/ml appears to ensure a successful induction of anaesthesia without a significant increase in the incidence of apnoea.</description><identifier>ISSN: 0042-4900</identifier><identifier>EISSN: 2042-7670</identifier><identifier>DOI: 10.1136/vr.157.24.766</identifier><identifier>PMID: 16339979</identifier><language>eng</language><publisher>England: BMJ Publishing Group Limited</publisher><subject>anesthesia ; Anesthetics, Intravenous - blood ; Anesthetics, Intravenous - pharmacokinetics ; Animals ; Apnea - epidemiology ; Apnea - veterinary ; Blood Pressure ; Dog Diseases - epidemiology ; dogs ; Dogs - physiology ; Dose-Response Relationship, Drug ; Female ; Heart Rate - drug effects ; Heart Rate - physiology ; Incidence ; intravenous injection ; Male ; propofol ; Propofol - blood ; Propofol - pharmacokinetics ; Prospective Studies ; Respiration - drug effects</subject><ispartof>Veterinary record, 2005-12, Vol.157 (24), p.766-770</ispartof><rights>British Veterinary Association. All rights reserved.</rights><rights>British Veterinary Association 2005</rights><rights>Copyright: 2005 British Veterinary Association. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4625-5026acfd280b1dfd8698cb183c0998fc83fb540ca790f98c6f2987df4db7249c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1136%2Fvr.157.24.766$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1136%2Fvr.157.24.766$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16339979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Musk, G. C.</creatorcontrib><creatorcontrib>Pang, D. S. J.</creatorcontrib><creatorcontrib>Beths, T.</creatorcontrib><creatorcontrib>Flaherty, D. A.</creatorcontrib><title>Target-controlled infusion of propofol in dogs – evaluation of four targets for induction of anaesthesia</title><title>Veterinary record</title><addtitle>Vet Rec</addtitle><description>Four groups of 20 dogs were anaesthetised by means of target-controlled infusions of propofol designed to achieve 2·5 µg/ml, 3·0 µg/ml, 3·5 µg/ml or 4·0 µg/ml of propofol in blood. The dogs’ pulse rate and respiratory rate were recorded before premedication and induction, immediately after endotracheal intubation and three and five minutes later (times 0, 3 and 5, respectively), and their arterial blood pressure was recorded oscillometrically just before induction and at times 0, 3 and 5. The targets of 2·5, 3·0, 3·5 and 4·0 µg/ml resulted in the successful induction of anaesthesia in 13 (65 per cent), 16 (80 per cent), 20 (100 per cent) and 20 (100 per cent) of the dogs, respectively. The incidence of postinduction apnoea was 0 (0 per cent), one (5 per cent), two (10 per cent) and eight (40 per cent) at time 5 for groups 2·5, 3·0, 3·5 and 4·0 µg/ml, respectively, and its incidence at time 5 was significantly higher in the 4·0 µg/ml group (P<0·05) than in the other groups. In all the groups there was a significant (P<0·05) decrease in blood pressure between just before induction and the later measurements. Although there were no statistically significant differences between the groups in terms of inducing anaesthesia at a specific target, a target of 3·5 µg/ml appears to ensure a successful induction of anaesthesia without a significant increase in the incidence of apnoea.</description><subject>anesthesia</subject><subject>Anesthetics, Intravenous - blood</subject><subject>Anesthetics, Intravenous - pharmacokinetics</subject><subject>Animals</subject><subject>Apnea - epidemiology</subject><subject>Apnea - veterinary</subject><subject>Blood Pressure</subject><subject>Dog Diseases - epidemiology</subject><subject>dogs</subject><subject>Dogs - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Heart Rate - physiology</subject><subject>Incidence</subject><subject>intravenous injection</subject><subject>Male</subject><subject>propofol</subject><subject>Propofol - blood</subject><subject>Propofol - pharmacokinetics</subject><subject>Prospective Studies</subject><subject>Respiration - drug effects</subject><issn>0042-4900</issn><issn>2042-7670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc1u1DAUhS1ERYfCsluIVAl1k-HacfyzhKoFpEqVypSt5fhnmlEmHuxkqu54B96QJ6mnGVSJRVn52vfz8bk-CB1jmGNcsY_bOMc1nxM654y9QDMClJSccXiJZrCrqQQ4RK9TWgEQWVfkFTrErKqk5HKGVgsdl24oTeiHGLrO2aLt_Zja0BfBF5sYNsGHLh8WNixT8efX78JtdTfqYY_4MMZieFRJeRMzakfzt6t77dJw61Kr36ADr7vk3u7XI3Rzcb44-1peXn35dvbpsmwoI3VZA2HaeEsENNh6K5gUpsGiMiCl8EZUvqkpGM0l-NxinkjBrae24YRKUx2hD5NuNv9zzK-rdZuM6zrduzAmxYTImoxk8OQfcJVn6bM3hTmXVHBG60yVE2ViSCk6rzaxXet4rzCoXQRqG1WOQBGqcgSZf7dXHZu1s0_0_s8zwCbgru3c_fNq6sf54vrzBTABOyfvp4teB6WXsU3q5jsBXAGGGjNCM3E6Ec169R-bD_3OqgQ</recordid><startdate>20051210</startdate><enddate>20051210</enddate><creator>Musk, G. 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J. ; Beths, T. ; Flaherty, D. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4625-5026acfd280b1dfd8698cb183c0998fc83fb540ca790f98c6f2987df4db7249c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>anesthesia</topic><topic>Anesthetics, Intravenous - blood</topic><topic>Anesthetics, Intravenous - pharmacokinetics</topic><topic>Animals</topic><topic>Apnea - epidemiology</topic><topic>Apnea - veterinary</topic><topic>Blood Pressure</topic><topic>Dog Diseases - epidemiology</topic><topic>dogs</topic><topic>Dogs - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Heart Rate - physiology</topic><topic>Incidence</topic><topic>intravenous injection</topic><topic>Male</topic><topic>propofol</topic><topic>Propofol - blood</topic><topic>Propofol - pharmacokinetics</topic><topic>Prospective Studies</topic><topic>Respiration - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Musk, G. 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C.</au><au>Pang, D. S. J.</au><au>Beths, T.</au><au>Flaherty, D. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Target-controlled infusion of propofol in dogs – evaluation of four targets for induction of anaesthesia</atitle><jtitle>Veterinary record</jtitle><addtitle>Vet Rec</addtitle><date>2005-12-10</date><risdate>2005</risdate><volume>157</volume><issue>24</issue><spage>766</spage><epage>770</epage><pages>766-770</pages><issn>0042-4900</issn><eissn>2042-7670</eissn><abstract>Four groups of 20 dogs were anaesthetised by means of target-controlled infusions of propofol designed to achieve 2·5 µg/ml, 3·0 µg/ml, 3·5 µg/ml or 4·0 µg/ml of propofol in blood. The dogs’ pulse rate and respiratory rate were recorded before premedication and induction, immediately after endotracheal intubation and three and five minutes later (times 0, 3 and 5, respectively), and their arterial blood pressure was recorded oscillometrically just before induction and at times 0, 3 and 5. The targets of 2·5, 3·0, 3·5 and 4·0 µg/ml resulted in the successful induction of anaesthesia in 13 (65 per cent), 16 (80 per cent), 20 (100 per cent) and 20 (100 per cent) of the dogs, respectively. The incidence of postinduction apnoea was 0 (0 per cent), one (5 per cent), two (10 per cent) and eight (40 per cent) at time 5 for groups 2·5, 3·0, 3·5 and 4·0 µg/ml, respectively, and its incidence at time 5 was significantly higher in the 4·0 µg/ml group (P<0·05) than in the other groups. In all the groups there was a significant (P<0·05) decrease in blood pressure between just before induction and the later measurements. Although there were no statistically significant differences between the groups in terms of inducing anaesthesia at a specific target, a target of 3·5 µg/ml appears to ensure a successful induction of anaesthesia without a significant increase in the incidence of apnoea.</abstract><cop>England</cop><pub>BMJ Publishing Group Limited</pub><pmid>16339979</pmid><doi>10.1136/vr.157.24.766</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0042-4900 |
| ispartof | Veterinary record, 2005-12, Vol.157 (24), p.766-770 |
| issn | 0042-4900 2042-7670 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | anesthesia Anesthetics, Intravenous - blood Anesthetics, Intravenous - pharmacokinetics Animals Apnea - epidemiology Apnea - veterinary Blood Pressure Dog Diseases - epidemiology dogs Dogs - physiology Dose-Response Relationship, Drug Female Heart Rate - drug effects Heart Rate - physiology Incidence intravenous injection Male propofol Propofol - blood Propofol - pharmacokinetics Prospective Studies Respiration - drug effects |
| title | Target-controlled infusion of propofol in dogs – evaluation of four targets for induction of anaesthesia |
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