Molecular design of biodegradable polymeric micelles for temperature-responsive drug release

We designed thermo-responsive and biodegradable polymeric micelles for an ideal drug delivery system whose target sites are where external stimuli selectively release drugs from the polymeric micelles. The thermo-responsive micelles formed from block copolymers that were composed both of a hydrophob...

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Veröffentlicht in:	Journal of controlled release 2006-09, Vol.115 (1), p.46-56
Hauptverfasser:	Nakayama, Masamichi, Okano, Teruo, Miyazaki, Takanari, Kohori, Fukashi, Sakai, Kiyotaka, Yokoyama, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - chemistry Biodegradable polymer Biological and medical sciences Biotransformation Delayed-Action Preparations Doxorubicin - administration & dosage Doxorubicin - chemistry Drug Design General pharmacology Indicators and Reagents Light Medical sciences Micelles Microdialysis Molecular Weight Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyesters Polymeric micelle Polymers Scattering, Radiation Spectrometry, Fluorescence Structure-Activity Relationship Targeting Temperature Thermo-response Ultrafiltration
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