Abrogation of delayed type hypersensitivity response to Candida albicans produced by a molecular mimic of phosphorylated prolactin

The effects of two major forms of prolactin (PRL) were examined on delayed type hypersensitivity (DTH) responses to Candida albicans. Unmodified PRL (U-PRL) had no effect on the DTH response, whereas a molecular mimic of phosphorylated PRL (S179D PRL) significantly inhibited immune responses to this...

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Veröffentlicht in:	Journal of neuroimmunology 2005-12, Vol.170 (1), p.31-40
Hauptverfasser:	Guzmán, E.A., Chen, Y.-H., Langowski, J.L., De Guzman, A., Lo, H.-L., Walter, B., Muller, H.K., Walker, A.M., Owen, L.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-flammatory Antibodies, Fungal - immunology Antibody Formation - drug effects Apoptosis - drug effects Candida albicans Candida albicans - immunology Cytokines Cytokines - antagonists & inhibitors Delayed type hypersensitivity Fas ligand Fas Ligand Protein Hypersensitivity, Delayed - immunology Hypersensitivity, Delayed - physiopathology Immunoglobulin G - metabolism Inflammation Mediators - antagonists & inhibitors Lymph Nodes - metabolism Male Membrane Glycoproteins - metabolism Mice Mice, Inbred Strains Molecular Mimicry Phosphorylated prolactin Phosphorylation Prolactin - metabolism Prolactin - pharmacology Spleen - pathology Spleen - physiopathology Tumor Necrosis Factors - metabolism
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