Immunodominance of Poxviral-Specific CTL in a Human Trial of Recombinant-Modified Vaccinia Ankara

Many recombinant poxviral vaccines are currently in clinical trials for cancer and infectious diseases. However, these agents have failed to generate T cell responses specific for recombinant gene products at levels comparable with T cell responses associated with natural viral infections. The recen...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-12, Vol.175 (12), p.8431-8437
Hauptverfasser:	Smith, Caroline L, Mirza, Fareed, Pasquetto, Valerie, Tscharke, David C, Palmowski, Michael J, Dunbar, P. Rod, Sette, Alessandro, Harris, Adrian L, Cerundolo, Vincenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	HLA-A Antigens HLA-A2 Antigen Humans Immunodominant Epitopes Kinetics Melanoma - immunology Melanoma - therapy Poxviridae - immunology T-Cell Antigen Receptor Specificity T-Lymphocytes, Cytotoxic - immunology Vaccines, Synthetic - immunology Vaccines, Synthetic - standards Vaccines, Synthetic - therapeutic use Vaccinia virus Vaccinia virus - immunology
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