Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

Key Points The phosphatidylinositol-3-kinase (PI3K) pathway plays a crucial role in cell growth and survival and is activated in various cancers. Multiple components of the pathway are frequently targeted by amplification, mutation, and, less commonly, translocation in neoplasia; there is also cross...

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Veröffentlicht in:	Nature reviews. Drug discovery 2005-12, Vol.4 (12), p.988-1004
Hauptverfasser:	Hennessy, Bryan T., Smith, Debra L., Ram, Prahlad T., Lu, Yiling, Mills, Gordon B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimitotic agents Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biomedical and Life Sciences Biomedicine Biotechnology Cancer Cancer Research Drug Design Drug Evaluation - methods Drug therapy Gene Amplification - drug effects Gene mutations Humans Medicinal Chemistry Molecular Medicine Mutation - drug effects Pharmacology/Toxicology Phosphatidylinositol 3-Kinases - drug effects Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Physiological aspects Product development Proto-Oncogene Proteins c-akt - drug effects Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism review-article Signal Transduction - drug effects Translocation, Genetic - drug effects
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