Inhibition of mRNA deadenylation and degradation by ultraviolet light

Post-transcriptional mechanisms contribute to the changes in gene expression induced by cell stress. The effect of UV-B light on mRNA degradation in HeLa cells was investigated using a transcriptional chase system to determine the decay kinetics of tet-off vector-derived mRNAs containing or lacking...

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Veröffentlicht in:	Biological chemistry 2005-12, Vol.386 (12), p.1287-1293
Hauptverfasser:	Gowrishankar, Gayatri, Winzen, Reinhard, Bollig, Frank, Ghebremedhin, Beniam, Redich, Natalie, Ritter, Birgit, Resch, Klaus, Kracht, Michael, Holtmann, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - antagonists & inhibitors Adenine - metabolism AU-rich element cytokines Cytokines - genetics Cytokines - metabolism Electrophoresis, Polyacrylamide Gel HeLa Cells - metabolism HeLa Cells - radiation effects Humans inflammation Interleukin-8 - genetics Interleukin-8 - metabolism Kinetics mRNA stability Poly A - genetics Poly A - metabolism poly(A)-tail RNA Stability - genetics RNA Stability - physiology RNA Stability - radiation effects RNA, Messenger - antagonists & inhibitors RNA, Messenger - metabolism RNA, Messenger - radiation effects Ultraviolet Rays UV light
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