Therapy-Induced Acute Recruitment of Circulating Endothelial Progenitor Cells to Tumors

The contribution of bone marrow-derived circulating endothelial progenitor cells (CEPs) to tumor angiogenesis has been controversial, primarily because of their low numbers in blood vessels of untreated tumors. We show that treatment of tumor-bearing mice with vascular disrupting agents (VDAs) leads...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2006-09, Vol.313 (5794), p.1785-1787
Hauptverfasser:	Shaked, Yuval, Ciarrocchi, Alessia, Franco, Marcela, Lee, Christina R, Man, Shan, Cheung, Alison M, Hicklin, Daniel J, Chaplin, David, Foster, F. Stuart, Benezra, Robert, Kerbel, Robert S
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis inhibitors Angiogenesis Inhibitors - therapeutic use Animal tumors. Experimental tumors Animals Antibodies, Monoclonal - therapeutic use Antineoplastic Agents, Phytogenic - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antineoplastics Biological and medical sciences Blood vessels Bone marrow Bone marrow cells Bone Marrow Cells - cytology Bone Marrow Cells - physiology Bones Cell Hypoxia Cell Line, Tumor Cells Diphosphates - therapeutic use Dosage Drug therapy Endothelial Cells - cytology Experimental tumors, general aspects Humans Hypoxia Medical sciences Mice Mice, Inbred C57BL Mice, Nude Necrosis Neoplasm Transplantation Neoplasms, Experimental - blood supply Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Neovascularization, Pathologic Stem Cells - physiology Stilbenes - therapeutic use Tumors
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