Therapy-Induced Acute Recruitment of Circulating Endothelial Progenitor Cells to Tumors
The contribution of bone marrow-derived circulating endothelial progenitor cells (CEPs) to tumor angiogenesis has been controversial, primarily because of their low numbers in blood vessels of untreated tumors. We show that treatment of tumor-bearing mice with vascular disrupting agents (VDAs) leads...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2006-09, Vol.313 (5794), p.1785-1787 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 313 |
| creator | Shaked, Yuval Ciarrocchi, Alessia Franco, Marcela Lee, Christina R Man, Shan Cheung, Alison M Hicklin, Daniel J Chaplin, David Foster, F. Stuart Benezra, Robert Kerbel, Robert S |
| description | The contribution of bone marrow-derived circulating endothelial progenitor cells (CEPs) to tumor angiogenesis has been controversial, primarily because of their low numbers in blood vessels of untreated tumors. We show that treatment of tumor-bearing mice with vascular disrupting agents (VDAs) leads to an acute mobilization of CEPs, which home to the viable tumor rim that characteristically remains after such therapy. Disruption of this CEP spike by antiangiogenic drugs or by genetic manipulation resulted in marked reductions in tumor rim size and blood flow as well as enhanced VDA antitumor activity. These findings also provide a mechanistic rationale for the enhanced efficacy of VDAs when combined with antiangiogenic drugs. |
| doi_str_mv | 10.1126/science.1127592 |
| format | Article |
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These findings also provide a mechanistic rationale for the enhanced efficacy of VDAs when combined with antiangiogenic drugs.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1127592</identifier><identifier>PMID: 16990548</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Angiogenesis inhibitors ; Angiogenesis Inhibitors - therapeutic use ; Animal tumors. 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These findings also provide a mechanistic rationale for the enhanced efficacy of VDAs when combined with antiangiogenic drugs.</description><subject>Angiogenesis inhibitors</subject><subject>Angiogenesis Inhibitors - therapeutic use</subject><subject>Animal tumors. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2006-09, Vol.313 (5794), p.1785-1787 |
| issn | 0036-8075 1095-9203 |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Angiogenesis inhibitors Angiogenesis Inhibitors - therapeutic use Animal tumors. Experimental tumors Animals Antibodies, Monoclonal - therapeutic use Antineoplastic Agents, Phytogenic - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antineoplastics Biological and medical sciences Blood vessels Bone marrow Bone marrow cells Bone Marrow Cells - cytology Bone Marrow Cells - physiology Bones Cell Hypoxia Cell Line, Tumor Cells Diphosphates - therapeutic use Dosage Drug therapy Endothelial Cells - cytology Experimental tumors, general aspects Humans Hypoxia Medical sciences Mice Mice, Inbred C57BL Mice, Nude Necrosis Neoplasm Transplantation Neoplasms, Experimental - blood supply Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Neovascularization, Pathologic Stem Cells - physiology Stilbenes - therapeutic use Tumors |
| title | Therapy-Induced Acute Recruitment of Circulating Endothelial Progenitor Cells to Tumors |
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