Antioxidant status in children with homozygous thalassemia
The status of enzymatic and non-enzymatic anti-oxidants was evaluated in 41 patients with transfusion dependent beta-thalassemia. An additional 20 age-matched children, with non-hemolytic anemia, served as controls. Fresh blood samples, obtained in the morning, were processed immediately. Plasma was...
Gespeichert in:
| Veröffentlicht in: | Indian pediatrics 2005-11, Vol.42 (11), p.1141-1145 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1145 |
|---|---|
| container_issue | 11 |
| container_start_page | 1141 |
| container_title | Indian pediatrics |
| container_volume | 42 |
| creator | Dhawan, Veena Kumar, Kh Ratan Marwaha, R K Ganguly, Nirmal K |
| description | The status of enzymatic and non-enzymatic anti-oxidants was evaluated in 41 patients with transfusion dependent beta-thalassemia. An additional 20 age-matched children, with non-hemolytic anemia, served as controls. Fresh blood samples, obtained in the morning, were processed immediately. Plasma was stored at -80 degrees C. Levels of vitamins A and E were assayed simultaneously by HPLC. RBC vitamin A was not measurable in 29 (70.7%) thalassemics and in all the controls. Plasma vitamin A levels were lower in thalassemics than in controls (p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68883064</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68883064</sourcerecordid><originalsourceid>FETCH-LOGICAL-p545-845b98dd36ea253b31ee63aef573660da45db487c06ac4753f6ce52e769d3dab3</originalsourceid><addsrcrecordid>eNo1j8tOwzAQRb0AtaXwCygrdpGcjD1x2FUVL6kSm-6jSTxpjPIidgTl64lEWd3FPTq690pspEzyGCUma3Hj_YeUKaQ6WYl1gqCk1HojHnd9cMO3s9SHyAcKs49cH1WNa-3EffTlQhM1Qzf8nE_D0oWGWvKeO0e34rqm1vPdJbfi-Px03L_Gh_eXt_3uEI9a6dgoXebGWkCmVEMJCTMCca0zQJSWlLalMlklkSqVaaixYp1yhrkFSyVsxcOfdpyGz5l9KDrnK25b6nlZVKAxBiSqBby_gHPZsS3GyXU0nYv_s_ALqPNQCA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68883064</pqid></control><display><type>article</type><title>Antioxidant status in children with homozygous thalassemia</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Dhawan, Veena ; Kumar, Kh Ratan ; Marwaha, R K ; Ganguly, Nirmal K</creator><creatorcontrib>Dhawan, Veena ; Kumar, Kh Ratan ; Marwaha, R K ; Ganguly, Nirmal K</creatorcontrib><description>The status of enzymatic and non-enzymatic anti-oxidants was evaluated in 41 patients with transfusion dependent beta-thalassemia. An additional 20 age-matched children, with non-hemolytic anemia, served as controls. Fresh blood samples, obtained in the morning, were processed immediately. Plasma was stored at -80 degrees C. Levels of vitamins A and E were assayed simultaneously by HPLC. RBC vitamin A was not measurable in 29 (70.7%) thalassemics and in all the controls. Plasma vitamin A levels were lower in thalassemics than in controls (p<0.05). Vitamin E in RBCs was not measurable in 13 (31. 7%) cases. The mean level of RBC vitamin E was 3 times lower in thalassemics. Similarly, SOD enzyme activity in thalassemics, was at least 1.5 lower in comparison to the activity documented in controls (p<0. 05). The observations indicate that thalassemics have enhanced oxidative stress. Administration of selective antioxidants and a balanced diet may preclude oxidative damage.</description><identifier>ISSN: 0019-6061</identifier><identifier>PMID: 16340055</identifier><language>eng</language><publisher>India</publisher><subject>beta-Thalassemia - blood ; Child ; Erythrocytes - metabolism ; Female ; Humans ; Male ; Superoxide Dismutase - blood ; Vitamin A - blood ; Vitamin E - blood</subject><ispartof>Indian pediatrics, 2005-11, Vol.42 (11), p.1141-1145</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16340055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dhawan, Veena</creatorcontrib><creatorcontrib>Kumar, Kh Ratan</creatorcontrib><creatorcontrib>Marwaha, R K</creatorcontrib><creatorcontrib>Ganguly, Nirmal K</creatorcontrib><title>Antioxidant status in children with homozygous thalassemia</title><title>Indian pediatrics</title><addtitle>Indian Pediatr</addtitle><description>The status of enzymatic and non-enzymatic anti-oxidants was evaluated in 41 patients with transfusion dependent beta-thalassemia. An additional 20 age-matched children, with non-hemolytic anemia, served as controls. Fresh blood samples, obtained in the morning, were processed immediately. Plasma was stored at -80 degrees C. Levels of vitamins A and E were assayed simultaneously by HPLC. RBC vitamin A was not measurable in 29 (70.7%) thalassemics and in all the controls. Plasma vitamin A levels were lower in thalassemics than in controls (p<0.05). Vitamin E in RBCs was not measurable in 13 (31. 7%) cases. The mean level of RBC vitamin E was 3 times lower in thalassemics. Similarly, SOD enzyme activity in thalassemics, was at least 1.5 lower in comparison to the activity documented in controls (p<0. 05). The observations indicate that thalassemics have enhanced oxidative stress. Administration of selective antioxidants and a balanced diet may preclude oxidative damage.</description><subject>beta-Thalassemia - blood</subject><subject>Child</subject><subject>Erythrocytes - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Superoxide Dismutase - blood</subject><subject>Vitamin A - blood</subject><subject>Vitamin E - blood</subject><issn>0019-6061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j8tOwzAQRb0AtaXwCygrdpGcjD1x2FUVL6kSm-6jSTxpjPIidgTl64lEWd3FPTq690pspEzyGCUma3Hj_YeUKaQ6WYl1gqCk1HojHnd9cMO3s9SHyAcKs49cH1WNa-3EffTlQhM1Qzf8nE_D0oWGWvKeO0e34rqm1vPdJbfi-Px03L_Gh_eXt_3uEI9a6dgoXebGWkCmVEMJCTMCca0zQJSWlLalMlklkSqVaaixYp1yhrkFSyVsxcOfdpyGz5l9KDrnK25b6nlZVKAxBiSqBby_gHPZsS3GyXU0nYv_s_ALqPNQCA</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Dhawan, Veena</creator><creator>Kumar, Kh Ratan</creator><creator>Marwaha, R K</creator><creator>Ganguly, Nirmal K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200511</creationdate><title>Antioxidant status in children with homozygous thalassemia</title><author>Dhawan, Veena ; Kumar, Kh Ratan ; Marwaha, R K ; Ganguly, Nirmal K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p545-845b98dd36ea253b31ee63aef573660da45db487c06ac4753f6ce52e769d3dab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>beta-Thalassemia - blood</topic><topic>Child</topic><topic>Erythrocytes - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Superoxide Dismutase - blood</topic><topic>Vitamin A - blood</topic><topic>Vitamin E - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dhawan, Veena</creatorcontrib><creatorcontrib>Kumar, Kh Ratan</creatorcontrib><creatorcontrib>Marwaha, R K</creatorcontrib><creatorcontrib>Ganguly, Nirmal K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Indian pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dhawan, Veena</au><au>Kumar, Kh Ratan</au><au>Marwaha, R K</au><au>Ganguly, Nirmal K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant status in children with homozygous thalassemia</atitle><jtitle>Indian pediatrics</jtitle><addtitle>Indian Pediatr</addtitle><date>2005-11</date><risdate>2005</risdate><volume>42</volume><issue>11</issue><spage>1141</spage><epage>1145</epage><pages>1141-1145</pages><issn>0019-6061</issn><abstract>The status of enzymatic and non-enzymatic anti-oxidants was evaluated in 41 patients with transfusion dependent beta-thalassemia. An additional 20 age-matched children, with non-hemolytic anemia, served as controls. Fresh blood samples, obtained in the morning, were processed immediately. Plasma was stored at -80 degrees C. Levels of vitamins A and E were assayed simultaneously by HPLC. RBC vitamin A was not measurable in 29 (70.7%) thalassemics and in all the controls. Plasma vitamin A levels were lower in thalassemics than in controls (p<0.05). Vitamin E in RBCs was not measurable in 13 (31. 7%) cases. The mean level of RBC vitamin E was 3 times lower in thalassemics. Similarly, SOD enzyme activity in thalassemics, was at least 1.5 lower in comparison to the activity documented in controls (p<0. 05). The observations indicate that thalassemics have enhanced oxidative stress. Administration of selective antioxidants and a balanced diet may preclude oxidative damage.</abstract><cop>India</cop><pmid>16340055</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0019-6061 |
| ispartof | Indian pediatrics, 2005-11, Vol.42 (11), p.1141-1145 |
| issn | 0019-6061 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68883064 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | beta-Thalassemia - blood Child Erythrocytes - metabolism Female Humans Male Superoxide Dismutase - blood Vitamin A - blood Vitamin E - blood |
| title | Antioxidant status in children with homozygous thalassemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T06%3A10%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antioxidant%20status%20in%20children%20with%20homozygous%20thalassemia&rft.jtitle=Indian%20pediatrics&rft.au=Dhawan,%20Veena&rft.date=2005-11&rft.volume=42&rft.issue=11&rft.spage=1141&rft.epage=1145&rft.pages=1141-1145&rft.issn=0019-6061&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E68883064%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68883064&rft_id=info:pmid/16340055&rfr_iscdi=true |