Macrophage ABCG1 Deletion Disrupts Lipid Homeostasis in Alveolar Macrophages and Moderately Influences Atherosclerotic Lesion Development in LDL Receptor-Deficient Mice

OBJECTIVE—ABCG1 has recently been identified as a facilitator of cellular cholesterol and phospholipid efflux to high-density lipoprotein (HDL). Its expression in macrophages is induced during cholesterol uptake in macrophages and by liver X receptor (LXR). The role of macrophage ABCG1 in atheroscle...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2006-10, Vol.26 (10), p.2295-2300
Hauptverfasser:	Out, Ruud, Hoekstra, Menno, Hildebrand, Reeni B, Kruit, Janine K, Meurs, Illiana, Li, Zhaosha, Kuipers, Folkert, Van Berkel, Theo J.C, Van Eck, Miranda
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - pathology Atherosclerosis (general aspects, experimental research) Atherosclerosis - metabolism Atherosclerosis - pathology ATP Binding Cassette Transporter, Sub-Family G, Member 1 ATP-Binding Cassette Transporters - genetics Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Gene Deletion General and cellular metabolism. Vitamins Homeostasis Investigative techniques, diagnostic techniques (general aspects) Lipid Metabolism Lipids - blood Lung - metabolism Macrophages, Alveolar - metabolism Medical sciences Mice Mice, Knockout Pharmacology. Drug treatments Receptors, LDL - deficiency Ultrasonic investigative techniques
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