Staphylococcus aureus Adhesion via Spa, ClfA, and SdrCDE to Immobilized Platelets Demonstrates Shear-Dependent Behavior

OBJECTIVE—The objective of this study is to delineate the molecular mechanisms responsible for Staphylococcus aureus–platelet adhesion as a function of physiologically relevant wall shear stresses. METHODS AND RESULTS—A parallel plate flow chamber was used to quantify adhesion of wild-type, Spa, Clf...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2006-10, Vol.26 (10), p.2394-2400
Hauptverfasser:	George, Niraj Procopio Evagrio, Wei, Qi, Shin, Pyong Kyun, Konstantopoulos, Konstantinos, Ross, Julia M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - physiology Alanine - analogs & derivatives Alanine - pharmacology Atherosclerosis (general aspects, experimental research) Bacterial Adhesion - drug effects Bacterial Adhesion - physiology Biological and medical sciences Blood and lymphatic vessels Blood coagulation. Blood cells Blood Platelets - drug effects Blood Platelets - metabolism Blood Proteins - physiology Blood vessels and receptors Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fibrinogen - metabolism Fibrinogen - physiology Fundamental and applied biological sciences. Psychology Humans Medical sciences Molecular and cellular biology Oligopeptides - pharmacology Oxazoles - pharmacology Platelet Platelet Adhesiveness - drug effects Platelet Adhesiveness - physiology Platelet Aggregation Inhibitors - pharmacology Staphylococcus aureus - classification Staphylococcus aureus - physiology Stress, Mechanical Vertebrates: cardiovascular system von Willebrand Factor - physiology
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