Potassium channels: New targets in cancer therapy
Background: Potassium channels (KCh) are the most diverse and ubiquitous class of ion channels. KCh control membrane potential and contribute to nerve and cardiac action potentials and neurotransmitter release. KCh are also involved in insulin release, differentiation, activation, proliferation, apo...
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| Veröffentlicht in: | Cancer detection and prevention 2006-01, Vol.30 (4), p.375-385 |
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| container_title | Cancer detection and prevention |
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| creator | Felipe, Antonio Vicente, Rubén Villalonga, Núria Roura-Ferrer, Meritxell Martínez-Mármol, Ramón Solé, Laura Ferreres, Joan C. Condom, Enric |
| description | Background: Potassium channels (KCh) are the most diverse and ubiquitous class of ion channels. KCh control membrane potential and contribute to nerve and cardiac action potentials and neurotransmitter release. KCh are also involved in insulin release, differentiation, activation, proliferation, apoptosis, and several other physiological functions. The aim of this review is to provide an updated overview of the KCh role during the cell growth. Their potential use as pharmacological targets in cancer therapies is also discussed.
Methods: We searched PubMed (up to 2005) and identified relevant articles. Reprints were mainly obtained by on line subscription. Additional sources were identified through cross-referencing and obtained from Library services.
Results: KCh are responsible for some neurological and cardiovascular diseases and for a new medical discipline, channelopathies. Their role in congenital deafness, multiple sclerosis, episodic ataxia, LQT syndrome and diabetes has been proven. Furthermore, a large body of information suggests that KCh play a role in the cell cycle progression, and it is now accepted that cells require KCh to proliferate. Thus, KCh expression has been studied in a number of tumours and cancer cells.
Conclusions: Cancer is far from being considered a channelopathy. However, it seems appropriate to take into account the involvement of KCh in cancer progression and pathology when developing new strategies for cancer therapy. |
| doi_str_mv | 10.1016/j.cdp.2006.06.002 |
| format | Article |
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Methods: We searched PubMed (up to 2005) and identified relevant articles. Reprints were mainly obtained by on line subscription. Additional sources were identified through cross-referencing and obtained from Library services.
Results: KCh are responsible for some neurological and cardiovascular diseases and for a new medical discipline, channelopathies. Their role in congenital deafness, multiple sclerosis, episodic ataxia, LQT syndrome and diabetes has been proven. Furthermore, a large body of information suggests that KCh play a role in the cell cycle progression, and it is now accepted that cells require KCh to proliferate. Thus, KCh expression has been studied in a number of tumours and cancer cells.
Conclusions: Cancer is far from being considered a channelopathy. However, it seems appropriate to take into account the involvement of KCh in cancer progression and pathology when developing new strategies for cancer therapy.</description><identifier>ISSN: 0361-090X</identifier><identifier>ISSN: 1877-7821</identifier><identifier>EISSN: 1873-443X</identifier><identifier>EISSN: 1877-783X</identifier><identifier>DOI: 10.1016/j.cdp.2006.06.002</identifier><identifier>PMID: 16971052</identifier><identifier>CODEN: CDPRD4</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Cancer ; Cancer detection ; Cancer progression ; Cancer therapies ; CDK inhibitors ; Cell cycle ; Cell cycle control ; Cell growth ; Cell Proliferation ; Channelopathies ; Epidemiology ; G1/S transition ; G2 phase ; Gene therapy ; Genes ; Humans ; Ion Channel Gating ; Lymphocyte activation ; Membrane proteins ; Molecular-targeted therapies ; Neoplasms - metabolism ; Neoplasms - therapy ; Pharmacological targets ; Potassium ; Potassium channels ; Potassium Channels - metabolism ; Therapeutic targets ; Transduction pathways ; Tumor markers ; Tumors</subject><ispartof>Cancer detection and prevention, 2006-01, Vol.30 (4), p.375-385</ispartof><rights>2006 International Society for Preventive Oncology</rights><rights>Copyright Elsevier Limited 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-24e480617aedb1b4c66f42ec9fc7fba006d51f4fd1855170df16fe37c94831c83</citedby><cites>FETCH-LOGICAL-c379t-24e480617aedb1b4c66f42ec9fc7fba006d51f4fd1855170df16fe37c94831c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1426558339?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,64390,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16971052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Felipe, Antonio</creatorcontrib><creatorcontrib>Vicente, Rubén</creatorcontrib><creatorcontrib>Villalonga, Núria</creatorcontrib><creatorcontrib>Roura-Ferrer, Meritxell</creatorcontrib><creatorcontrib>Martínez-Mármol, Ramón</creatorcontrib><creatorcontrib>Solé, Laura</creatorcontrib><creatorcontrib>Ferreres, Joan C.</creatorcontrib><creatorcontrib>Condom, Enric</creatorcontrib><title>Potassium channels: New targets in cancer therapy</title><title>Cancer detection and prevention</title><addtitle>Cancer Detect Prev</addtitle><description>Background: Potassium channels (KCh) are the most diverse and ubiquitous class of ion channels. KCh control membrane potential and contribute to nerve and cardiac action potentials and neurotransmitter release. KCh are also involved in insulin release, differentiation, activation, proliferation, apoptosis, and several other physiological functions. The aim of this review is to provide an updated overview of the KCh role during the cell growth. Their potential use as pharmacological targets in cancer therapies is also discussed.
Methods: We searched PubMed (up to 2005) and identified relevant articles. Reprints were mainly obtained by on line subscription. Additional sources were identified through cross-referencing and obtained from Library services.
Results: KCh are responsible for some neurological and cardiovascular diseases and for a new medical discipline, channelopathies. Their role in congenital deafness, multiple sclerosis, episodic ataxia, LQT syndrome and diabetes has been proven. Furthermore, a large body of information suggests that KCh play a role in the cell cycle progression, and it is now accepted that cells require KCh to proliferate. Thus, KCh expression has been studied in a number of tumours and cancer cells.
Conclusions: Cancer is far from being considered a channelopathy. However, it seems appropriate to take into account the involvement of KCh in cancer progression and pathology when developing new strategies for cancer therapy.</description><subject>Animals</subject><subject>Cancer</subject><subject>Cancer detection</subject><subject>Cancer progression</subject><subject>Cancer therapies</subject><subject>CDK inhibitors</subject><subject>Cell cycle</subject><subject>Cell cycle control</subject><subject>Cell growth</subject><subject>Cell Proliferation</subject><subject>Channelopathies</subject><subject>Epidemiology</subject><subject>G1/S transition</subject><subject>G2 phase</subject><subject>Gene therapy</subject><subject>Genes</subject><subject>Humans</subject><subject>Ion Channel Gating</subject><subject>Lymphocyte activation</subject><subject>Membrane proteins</subject><subject>Molecular-targeted therapies</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - therapy</subject><subject>Pharmacological targets</subject><subject>Potassium</subject><subject>Potassium channels</subject><subject>Potassium Channels - metabolism</subject><subject>Therapeutic targets</subject><subject>Transduction pathways</subject><subject>Tumor markers</subject><subject>Tumors</subject><issn>0361-090X</issn><issn>1877-7821</issn><issn>1873-443X</issn><issn>1877-783X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kF1LwzAUhoMobn78AG-kIHjXmdOkaapXMvyCoV4o7C6k6Ynr2NqatMr-vSkbCF4IL5yb57y8PIScAZ0ABXG1nJiynSSUiskQmuyRMciMxZyz-T4ZUyYgpjmdj8iR90safnImDsko3AxomowJvDad9r7q15FZ6LrGlb-OnvE76rT7wM5HVR0ZXRt0UbdAp9vNCTmweuXxdHePyfv93dv0MZ69PDxNb2exYVnexQlHLqmATGNZQMGNEJYnaHJrMlvosLlMwXJbgkxTyGhpQVhkmcm5ZGAkOyaX297WNZ89-k6tK29wtdI1Nr1XQsosB5kE8OIPuGx6V4dtCngi0lQylgcKtpRxjfcOrWpdtdZuo4CqwaZaqmBTDTbVEDo0n--a-2KN5e_HTl8AbrZA0IZfFTrlTYXBVlk5NJ0qm-qf-h_7u4N0</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Felipe, Antonio</creator><creator>Vicente, Rubén</creator><creator>Villalonga, Núria</creator><creator>Roura-Ferrer, Meritxell</creator><creator>Martínez-Mármol, Ramón</creator><creator>Solé, Laura</creator><creator>Ferreres, Joan C.</creator><creator>Condom, Enric</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20060101</creationdate><title>Potassium channels: New targets in cancer therapy</title><author>Felipe, Antonio ; Vicente, Rubén ; Villalonga, Núria ; Roura-Ferrer, Meritxell ; Martínez-Mármol, Ramón ; Solé, Laura ; Ferreres, Joan C. ; Condom, Enric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-24e480617aedb1b4c66f42ec9fc7fba006d51f4fd1855170df16fe37c94831c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Cancer</topic><topic>Cancer detection</topic><topic>Cancer progression</topic><topic>Cancer therapies</topic><topic>CDK inhibitors</topic><topic>Cell cycle</topic><topic>Cell cycle control</topic><topic>Cell growth</topic><topic>Cell Proliferation</topic><topic>Channelopathies</topic><topic>Epidemiology</topic><topic>G1/S transition</topic><topic>G2 phase</topic><topic>Gene therapy</topic><topic>Genes</topic><topic>Humans</topic><topic>Ion Channel Gating</topic><topic>Lymphocyte activation</topic><topic>Membrane proteins</topic><topic>Molecular-targeted therapies</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - therapy</topic><topic>Pharmacological targets</topic><topic>Potassium</topic><topic>Potassium channels</topic><topic>Potassium Channels - metabolism</topic><topic>Therapeutic targets</topic><topic>Transduction pathways</topic><topic>Tumor markers</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Felipe, Antonio</creatorcontrib><creatorcontrib>Vicente, Rubén</creatorcontrib><creatorcontrib>Villalonga, Núria</creatorcontrib><creatorcontrib>Roura-Ferrer, Meritxell</creatorcontrib><creatorcontrib>Martínez-Mármol, Ramón</creatorcontrib><creatorcontrib>Solé, Laura</creatorcontrib><creatorcontrib>Ferreres, Joan C.</creatorcontrib><creatorcontrib>Condom, Enric</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Proquest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer detection and prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Felipe, Antonio</au><au>Vicente, Rubén</au><au>Villalonga, Núria</au><au>Roura-Ferrer, Meritxell</au><au>Martínez-Mármol, Ramón</au><au>Solé, Laura</au><au>Ferreres, Joan C.</au><au>Condom, Enric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potassium channels: New targets in cancer therapy</atitle><jtitle>Cancer detection and prevention</jtitle><addtitle>Cancer Detect Prev</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>30</volume><issue>4</issue><spage>375</spage><epage>385</epage><pages>375-385</pages><issn>0361-090X</issn><issn>1877-7821</issn><eissn>1873-443X</eissn><eissn>1877-783X</eissn><coden>CDPRD4</coden><abstract>Background: Potassium channels (KCh) are the most diverse and ubiquitous class of ion channels. KCh control membrane potential and contribute to nerve and cardiac action potentials and neurotransmitter release. KCh are also involved in insulin release, differentiation, activation, proliferation, apoptosis, and several other physiological functions. The aim of this review is to provide an updated overview of the KCh role during the cell growth. Their potential use as pharmacological targets in cancer therapies is also discussed.
Methods: We searched PubMed (up to 2005) and identified relevant articles. Reprints were mainly obtained by on line subscription. Additional sources were identified through cross-referencing and obtained from Library services.
Results: KCh are responsible for some neurological and cardiovascular diseases and for a new medical discipline, channelopathies. Their role in congenital deafness, multiple sclerosis, episodic ataxia, LQT syndrome and diabetes has been proven. Furthermore, a large body of information suggests that KCh play a role in the cell cycle progression, and it is now accepted that cells require KCh to proliferate. Thus, KCh expression has been studied in a number of tumours and cancer cells.
Conclusions: Cancer is far from being considered a channelopathy. However, it seems appropriate to take into account the involvement of KCh in cancer progression and pathology when developing new strategies for cancer therapy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16971052</pmid><doi>10.1016/j.cdp.2006.06.002</doi><tpages>11</tpages></addata></record> |
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| ispartof | Cancer detection and prevention, 2006-01, Vol.30 (4), p.375-385 |
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| language | eng |
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| subjects | Animals Cancer Cancer detection Cancer progression Cancer therapies CDK inhibitors Cell cycle Cell cycle control Cell growth Cell Proliferation Channelopathies Epidemiology G1/S transition G2 phase Gene therapy Genes Humans Ion Channel Gating Lymphocyte activation Membrane proteins Molecular-targeted therapies Neoplasms - metabolism Neoplasms - therapy Pharmacological targets Potassium Potassium channels Potassium Channels - metabolism Therapeutic targets Transduction pathways Tumor markers Tumors |
| title | Potassium channels: New targets in cancer therapy |
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