BML-241 fails to display selective antagonism at the sphingosine-1-phosphate receptor, S1P(3)

The thiazolidine carboxylic acid, BML-241, has been proposed as a lead compound in development of selective antagonists at the sphingosine-1-phosphate receptor (S1P3), based on its inhibition of the rise in intracellular calcium concentrations ([Ca2+]i) in HeLa cells overexpressing S1P receptors. We...

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Veröffentlicht in:	British journal of pharmacology 2006-10, Vol.149 (3), p.277-282
Hauptverfasser:	Jongsma, M, Hendriks-Balk, M C, Michel, M C, Peters, S L M, Alewijnse, A E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism CHO Cells Cricetinae Cyclic AMP - metabolism Prazosin - metabolism Receptors, Adrenergic, alpha-1 - drug effects Receptors, Lysosphingolipid - antagonists & inhibitors Receptors, Purinergic P2 - drug effects Thiazolidines - pharmacology Vasoconstriction - drug effects
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