IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy

The transforming growth factor-β (TGF-β) plays a central role in the progression of renal fibrosis. TGF-β transduces its signal through the activin receptor-like kinase (ALK)5. IN-1130, a novel small molecule ALK5 inhibitor, inhibited the purified kinase domain of ALK5-mediated Smad3 phosphorylation...

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Veröffentlicht in:	Kidney international 2006-10, Vol.70 (7), p.1234-1243
Hauptverfasser:	Moon, J.-A., Kim, H.-T., Cho, I.-S., Sheen, Y.Y., Kim, D.-K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Receptors - antagonists & inhibitors Activin Receptors, Type I - antagonists & inhibitors ALK5 Animals Atrophy Blotting, Western Data Interpretation, Statistical Disease Models, Animal Dose-Response Relationship, Drug Electrophoresis, Polyacrylamide Gel Female Fibronectins - analysis Fibrosis Immunohistochemistry IN-1130 Kidney - metabolism Kidney - pathology Kidney Diseases - etiology Kidney Diseases - genetics Kidney Diseases - metabolism Kidney Diseases - therapy Kidney Tubules - pathology Phosphorylation Polymerase Chain Reaction Protein Kinases - analysis Protein Kinases - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Rats Rats, Sprague-Dawley Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - metabolism Renal fibrosis RNA, Messenger - analysis RNA, Messenger - metabolism Smad2 Protein - genetics Smad2 Protein - metabolism Smad3 Protein - genetics Smad3 Protein - metabolism TGF-β Transforming Growth Factor beta1 - antagonists & inhibitors Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Ureteral Obstruction - complications Ureteral Obstruction - metabolism Ureteral Obstruction - pathology Ureteral Obstruction - therapy UUO
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