The Structural Context of Disease-causing Mutations in Gap Junctions

Gap junctions form intercellular channels that mediate metabolic and electrical signaling between neighboring cells in a tissue. Lack of an atomic resolution structure of the gap junction has made it difficult to identify interactions that stabilize its transmembrane domain. Using a recently compute...

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Veröffentlicht in:	The Journal of biological chemistry 2006-09, Vol.281 (39), p.28958-28963
Hauptverfasser:	Fleishman, Sarel J., Sabag, Adi D., Ophir, Eran, Avraham, Karen B., Ben-Tal, Nir
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Communication Connexin 26 Connexins - genetics Gap Junction beta-1 Protein Gap Junctions HeLa Cells Humans Models, Molecular Molecular Conformation Mutation Protein Conformation Protein Structure, Tertiary Signal Transduction Transfection
Online-Zugang:	Volltext
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