Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles

Different substituents were introduced in position 1 of 2-methyl-5(6)-nitro-1 H-benzimidazole ( 2) in order to obtain different side chains having different heterocyclic compounds, for example, thiadiazoles ( 5– 7), tetrazoles ( 8, 9a, b), triazoles ( 11– 13), thiazoles ( 14a– e), triazines ( 10, 16...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-11, Vol.14 (21), p.7324-7332
Hauptverfasser:	Ramla, Mostafa M., Omar, Mohamed A., El-Khamry, Abdel-Momen M., El-Diwani, Hoda I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antitumor activity Benzimidazole Benzimidazoles - chemical synthesis Benzimidazoles - pharmacology Biological and medical sciences General aspects Imidazoles Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Pharmacology. Drug treatments Spectrophotometry, Infrared Thiazoles Triazoles
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