Interference of Mycobacterium tuberculosis cell division by Rv2719c, a cell wall hydrolase

Summary The genetic factors responsible for the regulation of cell division in Mycobacterium tuberculosis are largely unknown. We showed that exposure of M. tuberculosis to DNA damaging agents, or to cephalexin, or growth of M. tuberculosis in macrophages increased cell length and sharply elevated t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular microbiology 2006-10, Vol.62 (1), p.132-147
Hauptverfasser:	Chauhan, Ashwini, Lofton, Hava, Maloney, Erin, Moore, Jacob, Fol, Marek, Madiraju, Murty V. V. S., Rajagopalan, Malini
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics Bacterial Proteins - metabolism Biological and medical sciences Cell division Cell Division - drug effects Cell Division - genetics Cell Division - physiology Cell Line Cell Survival Cell Wall - metabolism Cells, Cultured Cephalexin - pharmacology Cloning, Molecular Deoxyribonucleic acid DNA DNA damage Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Bacterial - drug effects Gene Expression Regulation, Bacterial - genetics Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - genetics Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Hydrolases - genetics Hydrolases - metabolism Hydrolysis - drug effects Immunoblotting Macrophages - cytology Macrophages - microbiology Microbiology Microscopy, Fluorescence Mutation - genetics Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - growth & development N-Acetylmuramoyl-L-alanine Amidase - genetics N-Acetylmuramoyl-L-alanine Amidase - metabolism Polymerization Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Tuberculosis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!