Block copolymer micelles: preparation, characterization and application in drug delivery
Block copolymer micelles are generally formed by the self-assembly of either amphiphilic or oppositely charged copolymers in aqueous medium. The hydrophilic and hydrophobic blocks form the corona and the core of the micelles, respectively. The presence of a nonionic water-soluble shell as well as th...
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| Veröffentlicht in: | Journal of controlled release 2005-12, Vol.109 (1), p.169-188 |
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| creator | Gaucher, Geneviève Dufresne, Marie-Hélène Sant, Vinayak P. Kang, Ning Maysinger, Dusica Leroux, Jean-Christophe |
| description | Block copolymer micelles are generally formed by the self-assembly of either amphiphilic or oppositely charged copolymers in aqueous medium. The hydrophilic and hydrophobic blocks form the corona and the core of the micelles, respectively. The presence of a nonionic water-soluble shell as well as the scale (10–100 nm) of polymeric micelles are expected to restrict their uptake by the mononuclear phagocyte system and allow for passive targeting of cancerous or inflamed tissues through the enhanced permeation and retention effect. Research in the field has been increasingly focused on achieving enhanced stability of the micellar assembly, prolonged circulation times and controlled release of the drug for optimal targeting. With that in mind, our group has developed a range of block copolymers for various applications, including amphiphilic micelles for passive targeting of chemotherapeutic agents and environment-sensitive micelles for the oral delivery of poorly bioavailable compounds. Here, we propose to review the innovations in block copolymer synthesis, polymeric micelle preparation and characterization, as well as the relevance of these developments to the field of biomedical research. |
| doi_str_mv | 10.1016/j.jconrel.2005.09.034 |
| format | Article |
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The hydrophilic and hydrophobic blocks form the corona and the core of the micelles, respectively. The presence of a nonionic water-soluble shell as well as the scale (10–100 nm) of polymeric micelles are expected to restrict their uptake by the mononuclear phagocyte system and allow for passive targeting of cancerous or inflamed tissues through the enhanced permeation and retention effect. Research in the field has been increasingly focused on achieving enhanced stability of the micellar assembly, prolonged circulation times and controlled release of the drug for optimal targeting. With that in mind, our group has developed a range of block copolymers for various applications, including amphiphilic micelles for passive targeting of chemotherapeutic agents and environment-sensitive micelles for the oral delivery of poorly bioavailable compounds. 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Drug treatments ; Polyion complex micelles ; Polymers - chemical synthesis ; Polymers - chemistry ; Targeting</subject><ispartof>Journal of controlled release, 2005-12, Vol.109 (1), p.169-188</ispartof><rights>2005 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-3b74d231f4bd49aa78c422095933a53dea2fa095f553685478767e493d83b07b3</citedby><cites>FETCH-LOGICAL-c490t-3b74d231f4bd49aa78c422095933a53dea2fa095f553685478767e493d83b07b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jconrel.2005.09.034$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3548,23929,23930,25139,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17366509$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16289422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gaucher, Geneviève</creatorcontrib><creatorcontrib>Dufresne, Marie-Hélène</creatorcontrib><creatorcontrib>Sant, Vinayak P.</creatorcontrib><creatorcontrib>Kang, Ning</creatorcontrib><creatorcontrib>Maysinger, Dusica</creatorcontrib><creatorcontrib>Leroux, Jean-Christophe</creatorcontrib><title>Block copolymer micelles: preparation, characterization and application in drug delivery</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Block copolymer micelles are generally formed by the self-assembly of either amphiphilic or oppositely charged copolymers in aqueous medium. The hydrophilic and hydrophobic blocks form the corona and the core of the micelles, respectively. The presence of a nonionic water-soluble shell as well as the scale (10–100 nm) of polymeric micelles are expected to restrict their uptake by the mononuclear phagocyte system and allow for passive targeting of cancerous or inflamed tissues through the enhanced permeation and retention effect. Research in the field has been increasingly focused on achieving enhanced stability of the micellar assembly, prolonged circulation times and controlled release of the drug for optimal targeting. With that in mind, our group has developed a range of block copolymers for various applications, including amphiphilic micelles for passive targeting of chemotherapeutic agents and environment-sensitive micelles for the oral delivery of poorly bioavailable compounds. Here, we propose to review the innovations in block copolymer synthesis, polymeric micelle preparation and characterization, as well as the relevance of these developments to the field of biomedical research.</description><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Block copolymer micelles</subject><subject>Cells - drug effects</subject><subject>Cells - metabolism</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems</subject><subject>Drug solubilization</subject><subject>Drug Stability</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Ligands</subject><subject>Medical sciences</subject><subject>Micelle stability</subject><subject>Micelles</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyion complex micelles</subject><subject>Polymers - chemical synthesis</subject><subject>Polymers - chemistry</subject><subject>Targeting</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EokvhJ4BygRMJdvzNpYKKL6kSF5C4WY49AS9OHOxspeXX42Uj9diTPaNnPK8fhJ4T3BFMxJt9t3dpzhC7HmPeYd1hyh6gHVGStkxr_hDtKqdaKri-QE9K2eMKUiYfowsieqVZ3-_Qj_cxud-NS0uKxwlyMwUHMUJ52ywZFpvtGtL8unG_6tWtkMPf_53Gzr6xyxKDO9dhbnw-_Gw8xHAL-fgUPRptLPBsOy_R948fvl1_bm--fvpy_e6mdUzjtaWDZL6nZGSDZ9paqVzNhTXXlFpOPdh-tLUcOadCcSaVFBKYpl7RAcuBXqJX53eXnP4coKxmCuX0BTtDOhQjlJJMYHkvSDTjRFBRQX4GXU6lZBjNksNk89EQbE7uzd5s7s3JvcHaVPd17sW24DBM4O-mNtkVeLkBtjgbx2xnF8odJ6kQHOvKXZ05qN5uA2RTXIDZgQ8Z3Gp8CvdE-QfReKUc</recordid><startdate>20051205</startdate><enddate>20051205</enddate><creator>Gaucher, Geneviève</creator><creator>Dufresne, Marie-Hélène</creator><creator>Sant, Vinayak P.</creator><creator>Kang, Ning</creator><creator>Maysinger, Dusica</creator><creator>Leroux, Jean-Christophe</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20051205</creationdate><title>Block copolymer micelles: preparation, characterization and application in drug delivery</title><author>Gaucher, Geneviève ; Dufresne, Marie-Hélène ; Sant, Vinayak P. ; Kang, Ning ; Maysinger, Dusica ; Leroux, Jean-Christophe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-3b74d231f4bd49aa78c422095933a53dea2fa095f553685478767e493d83b07b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Block copolymer micelles</topic><topic>Cells - drug effects</topic><topic>Cells - metabolism</topic><topic>Drug Carriers - chemical synthesis</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Delivery Systems</topic><topic>Drug solubilization</topic><topic>Drug Stability</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Ligands</topic><topic>Medical sciences</topic><topic>Micelle stability</topic><topic>Micelles</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyion complex micelles</topic><topic>Polymers - chemical synthesis</topic><topic>Polymers - chemistry</topic><topic>Targeting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaucher, Geneviève</creatorcontrib><creatorcontrib>Dufresne, Marie-Hélène</creatorcontrib><creatorcontrib>Sant, Vinayak P.</creatorcontrib><creatorcontrib>Kang, Ning</creatorcontrib><creatorcontrib>Maysinger, Dusica</creatorcontrib><creatorcontrib>Leroux, Jean-Christophe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaucher, Geneviève</au><au>Dufresne, Marie-Hélène</au><au>Sant, Vinayak P.</au><au>Kang, Ning</au><au>Maysinger, Dusica</au><au>Leroux, Jean-Christophe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Block copolymer micelles: preparation, characterization and application in drug delivery</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2005-12-05</date><risdate>2005</risdate><volume>109</volume><issue>1</issue><spage>169</spage><epage>188</epage><pages>169-188</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>Block copolymer micelles are generally formed by the self-assembly of either amphiphilic or oppositely charged copolymers in aqueous medium. The hydrophilic and hydrophobic blocks form the corona and the core of the micelles, respectively. The presence of a nonionic water-soluble shell as well as the scale (10–100 nm) of polymeric micelles are expected to restrict their uptake by the mononuclear phagocyte system and allow for passive targeting of cancerous or inflamed tissues through the enhanced permeation and retention effect. Research in the field has been increasingly focused on achieving enhanced stability of the micellar assembly, prolonged circulation times and controlled release of the drug for optimal targeting. With that in mind, our group has developed a range of block copolymers for various applications, including amphiphilic micelles for passive targeting of chemotherapeutic agents and environment-sensitive micelles for the oral delivery of poorly bioavailable compounds. Here, we propose to review the innovations in block copolymer synthesis, polymeric micelle preparation and characterization, as well as the relevance of these developments to the field of biomedical research.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>16289422</pmid><doi>10.1016/j.jconrel.2005.09.034</doi><tpages>20</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antineoplastic Agents - administration & dosage Biological and medical sciences Block copolymer micelles Cells - drug effects Cells - metabolism Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Delivery Systems Drug solubilization Drug Stability General pharmacology Humans Ligands Medical sciences Micelle stability Micelles Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyion complex micelles Polymers - chemical synthesis Polymers - chemistry Targeting |
| title | Block copolymer micelles: preparation, characterization and application in drug delivery |
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