Infliximab Therapy in Patients with Chronic Sarcoidosis and Pulmonary Involvement

Evidence suggests that tumor necrosis factor (TNF)-alpha plays an important role in the pathophysiology of sarcoidosis. To assess the efficacy of infliximab in sarcoidosis. A phase 2, multicenter, randomized, double-blind, placebo-controlled study was conducted in 138 patients with chronic pulmonary...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2006-10, Vol.174 (7), p.795-802
Hauptverfasser:	Baughman, Robert P, Drent, Marjolein, Kavuru, Mani, Judson, Marc A, Costabel, Ulrich, du Bois, Roland, Albera, Carlo, Brutsche, Martin, Davis, Gerald, Donohue, James F, Muller-Quernheim, Joachim, Schlenker-Herceg, Rozsa, Flavin, Susan, Lo, Kim Hung, Oemar, Barry, Barnathan, Elliot S, on behalf of Sarcoidosis Investigators
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Biological and medical sciences Chronic Disease Diseases of the respiratory system Female Humans Infliximab Infusions, Intravenous Intensive care medicine Male Medical sciences Middle Aged Peptidyl-Dipeptidase A - blood Pneumology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Sarcoidosis, Pulmonary - drug therapy Sarcoidosis, Pulmonary - physiopathology Treatment Outcome Tumor Necrosis Factor-alpha - antagonists & inhibitors Vital Capacity - drug effects
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