Dermatan carriers for neovascular transport targeting, deep tumor penetration and improved therapy

A new approach to functional tumor imaging and deep interstitial penetration of therapeutic agents is to target the upregulated transport activities of neovascular endothelium. Agents are formulated with the anionic glycosaminoglycan, 435-type dermatan sulfate (DS 435, 22.2 kDa), chemically enriched...

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Veröffentlicht in:	Journal of controlled release 2005-12, Vol.109 (1), p.222-235
Hauptverfasser:	Ranney, David, Antich, Peter, Dadey, Eric, Mason, Ralph, Kulkarni, Padmakar, Singh, Onkar, Chen, Huagang, Constantanescu, Anca, Parkey, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacokinetics Angiogenesis Inhibitors - therapeutic use Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - therapeutic use Biological and medical sciences Breast Neoplasms - diagnosis Breast Neoplasms - pathology Carbohydrate Sequence Carbohydrates - chemistry Chemistry, Pharmaceutical Deferoxamine - chemistry Dermatan Sulfate - chemistry Dermatan/carbohydrate carriers Doxorubicin - administration & dosage Doxorubicin - therapeutic use Doxorubicin nanoparticles Drug Carriers Drug Delivery Systems Female Gadolinium DTPA General pharmacology Heparin - chemistry Humans Iron Chelating Agents - chemistry Magnetic Resonance Imaging Male Medical sciences Mice Mice, Nude Microscopy, Fluorescence Molecular Sequence Data MR imaging polymers Neoplasm Transplantation Neoplasms - drug therapy Neoplasms - metabolism Neovascuar targeting Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Rats Tumor penetration
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