Mixed osteoclastic/pleomorphic giant cell tumor of the pancreas : A case report
Mixed giant cell tumor (MGCT) of the pancreas is a rare malignant neoplasm. The tumor contains pleomorphic giant cells (PGC), pleomorphic mononuclear cells (PMC) and osteoclastic giant cells (OGC). We describe the first fine needle aspiration biopsy (FNAB) diagnosis of this tumor. A 76-year-old woma...
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| Veröffentlicht in: | Acta cytologica 2005-09, Vol.49 (5), p.549-553 |
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| creator | EZENEKWE, Amobi M COLLINS, Brian T PONDER, T. Brent |
| description | Mixed giant cell tumor (MGCT) of the pancreas is a rare malignant neoplasm. The tumor contains pleomorphic giant cells (PGC), pleomorphic mononuclear cells (PMC) and osteoclastic giant cells (OGC). We describe the first fine needle aspiration biopsy (FNAB) diagnosis of this tumor.
A 76-year-old woman was discovered (on imaging studies) to have an apparently inoperable mass in the head of the pancreas. Computed tomography-guided FNAB showed a malignant neoplasm with features of an MGCT. PGC/PMC, OGC and spindle cells were present. The PGC/PMC expressed epithelial antigens, pancytokeratin, CAM 5.2, AE1/AE3 and epithelial membrane antigen (EMA). The spindle cells focally stained for EMA. OGC were negative for the epithelial antigens. OGC, PGC/PMC and the spindle cells were positive for the mesenchymal marker vimentin.
FNAB was instrumental in making the diagnosis of a rare pancreatic tumor, MGCT. Immunocytochemistry was helpful in making a definitive diagnosis and suggested that MGCT is a carcinosarcoma like neoplasm. The morphology and immunocytochemical profile raise the possibility that osteoclastic giant cell tumor and pleomorphic giant cell tumor may be different morphologic and biologic expressions of the same tumor. |
| doi_str_mv | 10.1159/000326204 |
| format | Article |
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A 76-year-old woman was discovered (on imaging studies) to have an apparently inoperable mass in the head of the pancreas. Computed tomography-guided FNAB showed a malignant neoplasm with features of an MGCT. PGC/PMC, OGC and spindle cells were present. The PGC/PMC expressed epithelial antigens, pancytokeratin, CAM 5.2, AE1/AE3 and epithelial membrane antigen (EMA). The spindle cells focally stained for EMA. OGC were negative for the epithelial antigens. OGC, PGC/PMC and the spindle cells were positive for the mesenchymal marker vimentin.
FNAB was instrumental in making the diagnosis of a rare pancreatic tumor, MGCT. Immunocytochemistry was helpful in making a definitive diagnosis and suggested that MGCT is a carcinosarcoma like neoplasm. The morphology and immunocytochemical profile raise the possibility that osteoclastic giant cell tumor and pleomorphic giant cell tumor may be different morphologic and biologic expressions of the same tumor.</description><identifier>ISSN: 0001-5547</identifier><identifier>EISSN: 1938-2650</identifier><identifier>DOI: 10.1159/000326204</identifier><identifier>PMID: 16334035</identifier><identifier>CODEN: ACYTAN</identifier><language>eng</language><publisher>St. Louis, MO: Science Printers and Publishers</publisher><subject>Aged ; Antigens, Surface - metabolism ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Biopsy, Fine-Needle ; Cell Shape ; Diagnosis, Differential ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Giant Cell Tumors - diagnostic imaging ; Giant Cell Tumors - metabolism ; Giant Cell Tumors - pathology ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Keratins - metabolism ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Mesoderm - metabolism ; Mesoderm - pathology ; Mixed Tumor, Malignant - diagnostic imaging ; Mixed Tumor, Malignant - metabolism ; Mixed Tumor, Malignant - pathology ; Osteoclasts - metabolism ; Osteoclasts - pathology ; Pancreas - diagnostic imaging ; Pancreas - metabolism ; Pancreas - pathology ; Pancreatic Neoplasms - diagnostic imaging ; Pancreatic Neoplasms - metabolism ; Pancreatic Neoplasms - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Tomography, X-Ray Computed ; Tumors ; Vimentin - metabolism</subject><ispartof>Acta cytologica, 2005-09, Vol.49 (5), p.549-553</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17104084$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16334035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EZENEKWE, Amobi M</creatorcontrib><creatorcontrib>COLLINS, Brian T</creatorcontrib><creatorcontrib>PONDER, T. Brent</creatorcontrib><title>Mixed osteoclastic/pleomorphic giant cell tumor of the pancreas : A case report</title><title>Acta cytologica</title><addtitle>Acta Cytol</addtitle><description>Mixed giant cell tumor (MGCT) of the pancreas is a rare malignant neoplasm. The tumor contains pleomorphic giant cells (PGC), pleomorphic mononuclear cells (PMC) and osteoclastic giant cells (OGC). We describe the first fine needle aspiration biopsy (FNAB) diagnosis of this tumor.
A 76-year-old woman was discovered (on imaging studies) to have an apparently inoperable mass in the head of the pancreas. Computed tomography-guided FNAB showed a malignant neoplasm with features of an MGCT. PGC/PMC, OGC and spindle cells were present. The PGC/PMC expressed epithelial antigens, pancytokeratin, CAM 5.2, AE1/AE3 and epithelial membrane antigen (EMA). The spindle cells focally stained for EMA. OGC were negative for the epithelial antigens. OGC, PGC/PMC and the spindle cells were positive for the mesenchymal marker vimentin.
FNAB was instrumental in making the diagnosis of a rare pancreatic tumor, MGCT. Immunocytochemistry was helpful in making a definitive diagnosis and suggested that MGCT is a carcinosarcoma like neoplasm. The morphology and immunocytochemical profile raise the possibility that osteoclastic giant cell tumor and pleomorphic giant cell tumor may be different morphologic and biologic expressions of the same tumor.</description><subject>Aged</subject><subject>Antigens, Surface - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biopsy, Fine-Needle</subject><subject>Cell Shape</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Giant Cell Tumors - diagnostic imaging</subject><subject>Giant Cell Tumors - metabolism</subject><subject>Giant Cell Tumors - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Keratins - metabolism</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Mesoderm - metabolism</subject><subject>Mesoderm - pathology</subject><subject>Mixed Tumor, Malignant - diagnostic imaging</subject><subject>Mixed Tumor, Malignant - metabolism</subject><subject>Mixed Tumor, Malignant - pathology</subject><subject>Osteoclasts - metabolism</subject><subject>Osteoclasts - pathology</subject><subject>Pancreas - diagnostic imaging</subject><subject>Pancreas - metabolism</subject><subject>Pancreas - pathology</subject><subject>Pancreatic Neoplasms - diagnostic imaging</subject><subject>Pancreatic Neoplasms - metabolism</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors</subject><subject>Vimentin - metabolism</subject><issn>0001-5547</issn><issn>1938-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1LxDAQBuAgiruuHvwDkove6k46SZp6k8UvWNmLnkuaJm6l3dQkBf33VlzxNPDy8DIzhJwzuGZMlEsAwFzmwA_InJWoslwKOCTzKWeZELyYkZMY3yeFUuIxmTGJyAHFnGye20_bUB-T9abTMbVmOXTW9z4M29bQt1bvEjW262gap5B6R9PW0kHvTLA60ht6S42OlgY7-JBOyZHTXbRn-7kgr_d3L6vHbL15eFrdrrMhxzJltdLGCYnaCpXzBoywILRrmECBUBuoRc4AhCqQNa5WpQNeguNgaq4aw3BBrn57h-A_RhtT1bfxZ029s36MlVSqYCjVBC_2cKx721RDaHsdvqq_F0zgcg90NLpzYbqsjf-uYMBBcfwG4qFogQ</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>EZENEKWE, Amobi M</creator><creator>COLLINS, Brian T</creator><creator>PONDER, T. Brent</creator><general>Science Printers and Publishers</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Mixed osteoclastic/pleomorphic giant cell tumor of the pancreas : A case report</title><author>EZENEKWE, Amobi M ; COLLINS, Brian T ; PONDER, T. Brent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-b8acf563ae5824d0c5e05afd153530bc0b5210058731dfb89f0490f40cb48dc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Antigens, Surface - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biopsy, Fine-Needle</topic><topic>Cell Shape</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Giant Cell Tumors - diagnostic imaging</topic><topic>Giant Cell Tumors - metabolism</topic><topic>Giant Cell Tumors - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Keratins - metabolism</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Mesoderm - metabolism</topic><topic>Mesoderm - pathology</topic><topic>Mixed Tumor, Malignant - diagnostic imaging</topic><topic>Mixed Tumor, Malignant - metabolism</topic><topic>Mixed Tumor, Malignant - pathology</topic><topic>Osteoclasts - metabolism</topic><topic>Osteoclasts - pathology</topic><topic>Pancreas - diagnostic imaging</topic><topic>Pancreas - metabolism</topic><topic>Pancreas - pathology</topic><topic>Pancreatic Neoplasms - diagnostic imaging</topic><topic>Pancreatic Neoplasms - metabolism</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors</topic><topic>Vimentin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EZENEKWE, Amobi M</creatorcontrib><creatorcontrib>COLLINS, Brian T</creatorcontrib><creatorcontrib>PONDER, T. Brent</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta cytologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EZENEKWE, Amobi M</au><au>COLLINS, Brian T</au><au>PONDER, T. Brent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mixed osteoclastic/pleomorphic giant cell tumor of the pancreas : A case report</atitle><jtitle>Acta cytologica</jtitle><addtitle>Acta Cytol</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>49</volume><issue>5</issue><spage>549</spage><epage>553</epage><pages>549-553</pages><issn>0001-5547</issn><eissn>1938-2650</eissn><coden>ACYTAN</coden><abstract>Mixed giant cell tumor (MGCT) of the pancreas is a rare malignant neoplasm. The tumor contains pleomorphic giant cells (PGC), pleomorphic mononuclear cells (PMC) and osteoclastic giant cells (OGC). We describe the first fine needle aspiration biopsy (FNAB) diagnosis of this tumor.
A 76-year-old woman was discovered (on imaging studies) to have an apparently inoperable mass in the head of the pancreas. Computed tomography-guided FNAB showed a malignant neoplasm with features of an MGCT. PGC/PMC, OGC and spindle cells were present. The PGC/PMC expressed epithelial antigens, pancytokeratin, CAM 5.2, AE1/AE3 and epithelial membrane antigen (EMA). The spindle cells focally stained for EMA. OGC were negative for the epithelial antigens. OGC, PGC/PMC and the spindle cells were positive for the mesenchymal marker vimentin.
FNAB was instrumental in making the diagnosis of a rare pancreatic tumor, MGCT. Immunocytochemistry was helpful in making a definitive diagnosis and suggested that MGCT is a carcinosarcoma like neoplasm. The morphology and immunocytochemical profile raise the possibility that osteoclastic giant cell tumor and pleomorphic giant cell tumor may be different morphologic and biologic expressions of the same tumor.</abstract><cop>St. Louis, MO</cop><pub>Science Printers and Publishers</pub><pmid>16334035</pmid><doi>10.1159/000326204</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Antigens, Surface - metabolism Biological and medical sciences Biomarkers, Tumor - metabolism Biopsy, Fine-Needle Cell Shape Diagnosis, Differential Female Gastroenterology. Liver. Pancreas. Abdomen Giant Cell Tumors - diagnostic imaging Giant Cell Tumors - metabolism Giant Cell Tumors - pathology Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Keratins - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mesoderm - metabolism Mesoderm - pathology Mixed Tumor, Malignant - diagnostic imaging Mixed Tumor, Malignant - metabolism Mixed Tumor, Malignant - pathology Osteoclasts - metabolism Osteoclasts - pathology Pancreas - diagnostic imaging Pancreas - metabolism Pancreas - pathology Pancreatic Neoplasms - diagnostic imaging Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Tomography, X-Ray Computed Tumors Vimentin - metabolism |
| title | Mixed osteoclastic/pleomorphic giant cell tumor of the pancreas : A case report |
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