Solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats
Intestinal absorption of various plant sterols was investigated in thoracic duct-cannulated normal rats. Lymphatic recovery was the highest in campesterol, intermediate in brassicasterol and sitosterol, and the lowest in stigmasterol and sitostanol. Higher solubility in the bile salt micelle was obs...
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| Veröffentlicht in: | Lipids 2006-06, Vol.41 (6), p.551-556 |
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| creator | Hamada, T Goto, H Yamahira, T Sugawara, T Imaizumi, K Ikeda, I |
| description | Intestinal absorption of various plant sterols was investigated in thoracic duct-cannulated normal rats. Lymphatic recovery was the highest in campesterol, intermediate in brassicasterol and sitosterol, and the lowest in stigmasterol and sitostanol. Higher solubility in the bile salt micelle was observed in sitosterol, campesterol, and sitostanol than in brassicasterol and stigmasterol. The solubility of the latter two sterols was extremely low. When the affinity of plant sterols for the bile salt micelle was compared in an in vitro model system, which assessed sterol transfer from the micellar to the oil phase, the transfer rate was the highest in brassicasterol, intermediate in campesterol and stigmasterol, and lowest in sitosterol and sitostanol. Although no significant correlations between lymphatic recovery of plant sterols and their micellar solubility or transfer rate from the bile salt micelle were observed, highly positive correlation was obtained between the lymphatic recovery and the multiplication value of the micellar solubility and the transfer rate. These observations strongly suggest that both solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats. |
| doi_str_mv | 10.1007/s11745-006-5004-y |
| format | Article |
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Lymphatic recovery was the highest in campesterol, intermediate in brassicasterol and sitosterol, and the lowest in stigmasterol and sitostanol. Higher solubility in the bile salt micelle was observed in sitosterol, campesterol, and sitostanol than in brassicasterol and stigmasterol. The solubility of the latter two sterols was extremely low. When the affinity of plant sterols for the bile salt micelle was compared in an in vitro model system, which assessed sterol transfer from the micellar to the oil phase, the transfer rate was the highest in brassicasterol, intermediate in campesterol and stigmasterol, and lowest in sitosterol and sitostanol. Although no significant correlations between lymphatic recovery of plant sterols and their micellar solubility or transfer rate from the bile salt micelle were observed, highly positive correlation was obtained between the lymphatic recovery and the multiplication value of the micellar solubility and the transfer rate. These observations strongly suggest that both solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-006-5004-y</identifier><identifier>PMID: 16981433</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer‐Verlag</publisher><subject>Absorption ; Animals ; Bile Acids and Salts - metabolism ; bile salts ; Cholestadienols - pharmacokinetics ; Cholesterol - analogs & derivatives ; Cholesterol - pharmacokinetics ; intestinal absorption ; Intestinal Absorption - physiology ; Lymph - metabolism ; Male ; Micelles ; Models, Biological ; phytosterols ; Phytosterols - chemistry ; Phytosterols - isolation & purification ; Phytosterols - pharmacokinetics ; Rats ; Rats, Wistar ; Salts ; Sitosterols - pharmacokinetics ; Solubility ; Stigmasterol - pharmacokinetics ; Triolein - metabolism</subject><ispartof>Lipids, 2006-06, Vol.41 (6), p.551-556</ispartof><rights>2006 American Oil Chemists' Society (AOCS)</rights><rights>Copyright AOCS Press Jun 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3981-daa3c5b343836755ad8eae3bee45cb4a8fee78f8a8a1a06b05b2046e7a2ef30e3</citedby><cites>FETCH-LOGICAL-c3981-daa3c5b343836755ad8eae3bee45cb4a8fee78f8a8a1a06b05b2046e7a2ef30e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs11745-006-5004-y$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs11745-006-5004-y$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16981433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamada, T</creatorcontrib><creatorcontrib>Goto, H</creatorcontrib><creatorcontrib>Yamahira, T</creatorcontrib><creatorcontrib>Sugawara, T</creatorcontrib><creatorcontrib>Imaizumi, K</creatorcontrib><creatorcontrib>Ikeda, I</creatorcontrib><title>Solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats</title><title>Lipids</title><addtitle>Lipids</addtitle><description>Intestinal absorption of various plant sterols was investigated in thoracic duct-cannulated normal rats. Lymphatic recovery was the highest in campesterol, intermediate in brassicasterol and sitosterol, and the lowest in stigmasterol and sitostanol. Higher solubility in the bile salt micelle was observed in sitosterol, campesterol, and sitostanol than in brassicasterol and stigmasterol. The solubility of the latter two sterols was extremely low. When the affinity of plant sterols for the bile salt micelle was compared in an in vitro model system, which assessed sterol transfer from the micellar to the oil phase, the transfer rate was the highest in brassicasterol, intermediate in campesterol and stigmasterol, and lowest in sitosterol and sitostanol. Although no significant correlations between lymphatic recovery of plant sterols and their micellar solubility or transfer rate from the bile salt micelle were observed, highly positive correlation was obtained between the lymphatic recovery and the multiplication value of the micellar solubility and the transfer rate. These observations strongly suggest that both solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats.</description><subject>Absorption</subject><subject>Animals</subject><subject>Bile Acids and Salts - metabolism</subject><subject>bile salts</subject><subject>Cholestadienols - pharmacokinetics</subject><subject>Cholesterol - analogs & derivatives</subject><subject>Cholesterol - pharmacokinetics</subject><subject>intestinal absorption</subject><subject>Intestinal Absorption - physiology</subject><subject>Lymph - metabolism</subject><subject>Male</subject><subject>Micelles</subject><subject>Models, Biological</subject><subject>phytosterols</subject><subject>Phytosterols - chemistry</subject><subject>Phytosterols - isolation & purification</subject><subject>Phytosterols - pharmacokinetics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Salts</subject><subject>Sitosterols - pharmacokinetics</subject><subject>Solubility</subject><subject>Stigmasterol - pharmacokinetics</subject><subject>Triolein - metabolism</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc1u1TAQhS0EoreFB2ADFovuAuPYTnyXqPxVuhJIpWtrkkzAVRIH2xHKE_DaOMqVkNiwsmf8neOxD2MvBLwRAPXbKEStdAFQFRpAFesjdhBam-IooX7MDgClKlQJ4oJdxviQS6GO-im7ENXRCCXlgf2-88PSuMGllbuJ49Rx7Hs3bXXvA08_iOdj4hGHxEfX0pAL3_N5wCnxmCj4IXIMxN04-5C2bke5Pbop7-PGZhMXsn2imHJ34NhEH-bk_LRdGjDFZ-xJj0Ok5-f1it1__PDt5nNx-vLp9ubdqWhlHrnoEGWrG6mkkVWtNXaGkGRDpHTbKDQ9UW16gwYFQtWAbkpQFdVYUi-B5BW73n3n4H8ueR47urg9CifyS7SVMTUIOGbw9T_gg19CHj7aslaVyq5lhsQOtcHHGKi3c3AjhtUKsFtEdo_I5ojsFpFds-bl2XhpRur-Ks6ZZKDegV_539f_O9rT7df3oLXIyle7skdv8Xtw0d7f5fglCAFKHJX8A5lvqVM</recordid><startdate>200606</startdate><enddate>200606</enddate><creator>Hamada, T</creator><creator>Goto, H</creator><creator>Yamahira, T</creator><creator>Sugawara, T</creator><creator>Imaizumi, K</creator><creator>Ikeda, I</creator><general>Springer‐Verlag</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>200606</creationdate><title>Solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats</title><author>Hamada, T ; Goto, H ; Yamahira, T ; Sugawara, T ; Imaizumi, K ; Ikeda, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3981-daa3c5b343836755ad8eae3bee45cb4a8fee78f8a8a1a06b05b2046e7a2ef30e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Bile Acids and Salts - metabolism</topic><topic>bile salts</topic><topic>Cholestadienols - pharmacokinetics</topic><topic>Cholesterol - analogs & derivatives</topic><topic>Cholesterol - pharmacokinetics</topic><topic>intestinal absorption</topic><topic>Intestinal Absorption - physiology</topic><topic>Lymph - metabolism</topic><topic>Male</topic><topic>Micelles</topic><topic>Models, Biological</topic><topic>phytosterols</topic><topic>Phytosterols - chemistry</topic><topic>Phytosterols - isolation & purification</topic><topic>Phytosterols - pharmacokinetics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Salts</topic><topic>Sitosterols - pharmacokinetics</topic><topic>Solubility</topic><topic>Stigmasterol - pharmacokinetics</topic><topic>Triolein - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamada, T</creatorcontrib><creatorcontrib>Goto, H</creatorcontrib><creatorcontrib>Yamahira, T</creatorcontrib><creatorcontrib>Sugawara, T</creatorcontrib><creatorcontrib>Imaizumi, K</creatorcontrib><creatorcontrib>Ikeda, I</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamada, T</au><au>Goto, H</au><au>Yamahira, T</au><au>Sugawara, T</au><au>Imaizumi, K</au><au>Ikeda, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>2006-06</date><risdate>2006</risdate><volume>41</volume><issue>6</issue><spage>551</spage><epage>556</epage><pages>551-556</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>Intestinal absorption of various plant sterols was investigated in thoracic duct-cannulated normal rats. Lymphatic recovery was the highest in campesterol, intermediate in brassicasterol and sitosterol, and the lowest in stigmasterol and sitostanol. Higher solubility in the bile salt micelle was observed in sitosterol, campesterol, and sitostanol than in brassicasterol and stigmasterol. The solubility of the latter two sterols was extremely low. When the affinity of plant sterols for the bile salt micelle was compared in an in vitro model system, which assessed sterol transfer from the micellar to the oil phase, the transfer rate was the highest in brassicasterol, intermediate in campesterol and stigmasterol, and lowest in sitosterol and sitostanol. Although no significant correlations between lymphatic recovery of plant sterols and their micellar solubility or transfer rate from the bile salt micelle were observed, highly positive correlation was obtained between the lymphatic recovery and the multiplication value of the micellar solubility and the transfer rate. These observations strongly suggest that both solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer‐Verlag</pub><pmid>16981433</pmid><doi>10.1007/s11745-006-5004-y</doi><tpages>6</tpages></addata></record> |
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| ispartof | Lipids, 2006-06, Vol.41 (6), p.551-556 |
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| subjects | Absorption Animals Bile Acids and Salts - metabolism bile salts Cholestadienols - pharmacokinetics Cholesterol - analogs & derivatives Cholesterol - pharmacokinetics intestinal absorption Intestinal Absorption - physiology Lymph - metabolism Male Micelles Models, Biological phytosterols Phytosterols - chemistry Phytosterols - isolation & purification Phytosterols - pharmacokinetics Rats Rats, Wistar Salts Sitosterols - pharmacokinetics Solubility Stigmasterol - pharmacokinetics Triolein - metabolism |
| title | Solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats |
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