Antiproliferative and apoptotic effects of zinc–citrate compound (CIZAR®) on human epithelial ovarian cancer cell line, OVCAR-3

Zinc inhibits the growth of several carcinoma cells through induction of cell cycle arrest and apoptosis. The intracellular concentration of zinc and its dynamic changes are critically important in cell biology. We investigated the effects of zinc–citrate compound (CIZAR®) on normal human ovarian ep...

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Veröffentlicht in:	Gynecologic oncology 2006-10, Vol.103 (1), p.127-136
Hauptverfasser:	Bae, Seog Nyeon, Lee, Yong Seok, Kim, Mi Yun, Kim, Jae Dong, Park, Lae Ok
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitate Hydratase - metabolism Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adenocarcinoma - pathology Apoptosis Apoptosis - drug effects Blotting, Western Caspase 12 Caspase 3 Caspases - metabolism Cell Cycle - drug effects Cell Growth Processes - drug effects Cell Line, Tumor Chlorides - pharmacology Citric Acid - pharmacology Dose-Response Relationship, Drug Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Female Flow Cytometry Humans Mitochondria - enzymology Ovarian cancer cells Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Telomerase - metabolism Zinc - metabolism Zinc Compounds - pharmacology Zinc–citrate
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