TLR4 Mediates LPS-Induced VEGF Expression in Odontoblasts

Lipopolysaccharide (LPS) from gram-negative bacteria cell walls such as Prevotella intermedia and Escherichia coli induce vascular endothelial growth factor (VEGF) expression in odontoblasts, but not in undifferentiated dental pulp cells. CD14 and TLR4 are responsible for LPS signaling in macrophage...

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Veröffentlicht in:	Journal of endodontics 2006-10, Vol.32 (10), p.951-955
Hauptverfasser:	Botero, Tatiana M., Shelburne, Charles E., Holland, G. Rex, Hanks, Carl T., Nör, Jacques E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Blotting, Western Cell Line Dental Pulp - cytology dental pulp cells Dentistry Escherichia coli Fibroblasts - physiology Flow Cytometry Gingiva - cytology Humans Immunohistochemistry Kidney - cytology Lipopolysaccharide Receptors - analysis Lipopolysaccharide Receptors - physiology Lipopolysaccharides - pharmacology LPS signaling Macrophages - physiology Mice Odontoblasts - physiology pulpitis Signal Transduction - physiology Toll-Like Receptor 4 - analysis Toll-Like Receptor 4 - physiology Transfection Up-Regulation Vascular Endothelial Growth Factor A - analysis Vascular Endothelial Growth Factor A - physiology vascular permeability
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