Carbon Nanohorns as Anticancer Drug Carriers
We demonstrate that oxidized single-wall carbon nanohorns (SWNHs), a type of single-wall nanotube, entrap cisplatin, an anticancer agent. We found that the cisplatin structure was maintained inside the SWNHs and that the cisplatin was slowly released from the SWNHs in aqueous environments. The relea...
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| Veröffentlicht in: | Molecular pharmaceutics 2005-11, Vol.2 (6), p.475-480 |
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| container_title | Molecular pharmaceutics |
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| creator | Ajima, Kumiko Yudasaka, Masako Murakami, Tatsuya Maigné, Alan Shiba, Kiyotaka Iijima, Sumio |
| description | We demonstrate that oxidized single-wall carbon nanohorns (SWNHs), a type of single-wall nanotube, entrap cisplatin, an anticancer agent. We found that the cisplatin structure was maintained inside the SWNHs and that the cisplatin was slowly released from the SWNHs in aqueous environments. The released cisplatin was effective in terminating the growth of human lung-cancer cells, while the SWNHs themselves had no such effect. Cisplatin-incorporated oxidized SWNHs are thus a potential drug delivery system. Keywords: Carbon nanotube; carbon nanohorn; anticancer drug; drug carrier; cisplatin |
| doi_str_mv | 10.1021/mp0500566 |
| format | Article |
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Pharmaceutics</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>2</volume><issue>6</issue><spage>475</spage><epage>480</epage><pages>475-480</pages><issn>1543-8384</issn><eissn>1543-8392</eissn><abstract>We demonstrate that oxidized single-wall carbon nanohorns (SWNHs), a type of single-wall nanotube, entrap cisplatin, an anticancer agent. We found that the cisplatin structure was maintained inside the SWNHs and that the cisplatin was slowly released from the SWNHs in aqueous environments. The released cisplatin was effective in terminating the growth of human lung-cancer cells, while the SWNHs themselves had no such effect. Cisplatin-incorporated oxidized SWNHs are thus a potential drug delivery system. Keywords: Carbon nanotube; carbon nanohorn; anticancer drug; drug carrier; cisplatin</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>16323954</pmid><doi>10.1021/mp0500566</doi><tpages>6</tpages></addata></record> |
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| ispartof | Molecular pharmaceutics, 2005-11, Vol.2 (6), p.475-480 |
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| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Antineoplastic Agents - pharmacokinetics Carbon Cell Line, Tumor Cisplatin - pharmacokinetics Drug Carriers Drug Delivery Systems Humans Lung Neoplasms |
| title | Carbon Nanohorns as Anticancer Drug Carriers |
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