Characterization of human Collagen XVIII promoter 2: Interaction of Sp1, Sp3 and YY1 with the regulatory region and a SNP that increases transcription in hepatocytes

Different levels of Collagen XVIII expression have been associated with several pathological processes such as cancer, liver fibrosis, diabetic retinopathy and Alzheimer's disease. Understanding the transcriptional regulation of Collagen XVIII might elucidate some pathways related to the progre...

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Veröffentlicht in:	Matrix biology 2005-12, Vol.24 (8), p.550-559
Hauptverfasser:	Armelin-Correa, Lucia M., Lin, Chin J., Barbosa, Angela, Bagatini, Kelly, Winnischofer, Sheila M.B., Sogayar, Mari C., Passos-Bueno, Maria Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cell Line, Tumor Collagen Type XVIII - genetics Collagen XVIII Conserved Sequence Functional SNP Genotype Hepatocytes - metabolism Humans Molecular Sequence Data Nucleoproteins - metabolism Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic - genetics Protein Binding Response Elements - genetics Sequence Alignment Sequence Homology, Nucleic Acid Sp1 Sp1 Transcription Factor - metabolism Sp3 Sp3 Transcription Factor - metabolism Transcription, Genetic - genetics Transcriptional regulation YY1 YY1 Transcription Factor - metabolism
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