Arthritis Due to Mycobacterium xenopi: A Retrospective Study of 7 Cases in France
Background. Mycobacterium xenopi is a nontuberculous mycobacterium responsible for opportunistic and nosocomial infections, chiefly of the lung; few cases of bone and joint infection have been reported. From July 1989 through May 1993, an outbreak of 58 cases of nosocomial discitis due to M. xenopi...
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| Veröffentlicht in: | Clinical infectious diseases 2006-10, Vol.43 (8), p.987-993 |
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| creator | Salliot, Carine Desplaces, Nicole Boisrenoult, Philippe Koeger, Anne Claude Beaufils, Philippe Vincent, Véronique Mamoudy, Patrick Ziza, Jean-Marc |
| description | Background. Mycobacterium xenopi is a nontuberculous mycobacterium responsible for opportunistic and nosocomial infections, chiefly of the lung; few cases of bone and joint infection have been reported. From July 1989 through May 1993, an outbreak of 58 cases of nosocomial discitis due to M. xenopi infection following percutaneous nucleotomy occurred in a French hospital. Peripheral M. xenopi arthritis seems exceedingly rare. We conducted a study to assess the epidemiological and clinical patterns of M. xenopi arthritis. Methods. We retrospectively reviewed cases of M. xenopi arthritis reported from May 1993 through October 2004. Results. We identified 7 cases, all of which occurred after invasive surgical procedures were performed on the affected joint, suggesting a nosocomial pattern of infection. Two patients may have been contaminated at the hospital where the M. xenopi discitis outbreak occurred. No source was identified in the other 5 patients. Despite the probable nosocomial nature of the infections, the diagnosis was delayed (mean time until diagnosis, 50 months). Repeated collection of deep tissue specimens for bacteriological analysis seemed crucial to the diagnosis. The treatment relied on combination antimicrobial therapy and surgery. Among 11 cases of M. xenopi osteoarticular infection reported in the literature from 1975 to 2005, (arthritis in 9 cases and osteitis in 2), none were nosocomial. Conclusion. A high index of suspicion should be maintained to ensure the diagnosis of M. xenopi arthritis before chronic monoarthritis and before the development of irreversible joint damage. |
| doi_str_mv | 10.1086/507631 |
| format | Article |
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Mycobacterium xenopi is a nontuberculous mycobacterium responsible for opportunistic and nosocomial infections, chiefly of the lung; few cases of bone and joint infection have been reported. From July 1989 through May 1993, an outbreak of 58 cases of nosocomial discitis due to M. xenopi infection following percutaneous nucleotomy occurred in a French hospital. Peripheral M. xenopi arthritis seems exceedingly rare. We conducted a study to assess the epidemiological and clinical patterns of M. xenopi arthritis. Methods. We retrospectively reviewed cases of M. xenopi arthritis reported from May 1993 through October 2004. Results. We identified 7 cases, all of which occurred after invasive surgical procedures were performed on the affected joint, suggesting a nosocomial pattern of infection. Two patients may have been contaminated at the hospital where the M. xenopi discitis outbreak occurred. No source was identified in the other 5 patients. Despite the probable nosocomial nature of the infections, the diagnosis was delayed (mean time until diagnosis, 50 months). Repeated collection of deep tissue specimens for bacteriological analysis seemed crucial to the diagnosis. The treatment relied on combination antimicrobial therapy and surgery. Among 11 cases of M. xenopi osteoarticular infection reported in the literature from 1975 to 2005, (arthritis in 9 cases and osteitis in 2), none were nosocomial. Conclusion. A high index of suspicion should be maintained to ensure the diagnosis of M. xenopi arthritis before chronic monoarthritis and before the development of irreversible joint damage.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/507631</identifier><identifier>PMID: 16983609</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Ankle Joint - microbiology ; Antibiotics ; Arthritis ; Arthritis, Infectious - microbiology ; Arthroplasty, Replacement, Knee - adverse effects ; Arthroscopy ; Arthroscopy - adverse effects ; Articles and Commentaries ; Biological and medical sciences ; Bones ; Cross Infection - microbiology ; Discitis ; Diseases of the osteoarticular system ; Diskectomy, Percutaneous - adverse effects ; Epidemiology ; Female ; France ; Humans ; Immunotherapy ; Infections ; Infectious diseases ; Joints ; Knee Joint - microbiology ; Knees ; Male ; Medical sciences ; Middle Aged ; Miscellaneous. Osteoarticular involvement in other diseases ; Mycobacterium Infections, Nontuberculous - microbiology ; Mycobacterium Infections, Nontuberculous - therapy ; Mycobacterium xenopi ; Pathogens ; Retrospective Studies ; Rheumatology ; Risk Factors</subject><ispartof>Clinical infectious diseases, 2006-10, Vol.43 (8), p.987-993</ispartof><rights>Copyright 2006 The Infectious Diseases Society of America</rights><rights>2006 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Oct 15, 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-7ee6d93d121064c8516c88cfce03b706200d11f456d473db374e899954b0b3423</citedby><cites>FETCH-LOGICAL-c424t-7ee6d93d121064c8516c88cfce03b706200d11f456d473db374e899954b0b3423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4485010$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4485010$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18184514$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16983609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salliot, Carine</creatorcontrib><creatorcontrib>Desplaces, Nicole</creatorcontrib><creatorcontrib>Boisrenoult, Philippe</creatorcontrib><creatorcontrib>Koeger, Anne Claude</creatorcontrib><creatorcontrib>Beaufils, Philippe</creatorcontrib><creatorcontrib>Vincent, Véronique</creatorcontrib><creatorcontrib>Mamoudy, Patrick</creatorcontrib><creatorcontrib>Ziza, Jean-Marc</creatorcontrib><title>Arthritis Due to Mycobacterium xenopi: A Retrospective Study of 7 Cases in France</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>Background. Mycobacterium xenopi is a nontuberculous mycobacterium responsible for opportunistic and nosocomial infections, chiefly of the lung; few cases of bone and joint infection have been reported. From July 1989 through May 1993, an outbreak of 58 cases of nosocomial discitis due to M. xenopi infection following percutaneous nucleotomy occurred in a French hospital. Peripheral M. xenopi arthritis seems exceedingly rare. We conducted a study to assess the epidemiological and clinical patterns of M. xenopi arthritis. Methods. We retrospectively reviewed cases of M. xenopi arthritis reported from May 1993 through October 2004. Results. We identified 7 cases, all of which occurred after invasive surgical procedures were performed on the affected joint, suggesting a nosocomial pattern of infection. Two patients may have been contaminated at the hospital where the M. xenopi discitis outbreak occurred. No source was identified in the other 5 patients. Despite the probable nosocomial nature of the infections, the diagnosis was delayed (mean time until diagnosis, 50 months). Repeated collection of deep tissue specimens for bacteriological analysis seemed crucial to the diagnosis. The treatment relied on combination antimicrobial therapy and surgery. Among 11 cases of M. xenopi osteoarticular infection reported in the literature from 1975 to 2005, (arthritis in 9 cases and osteitis in 2), none were nosocomial. Conclusion. A high index of suspicion should be maintained to ensure the diagnosis of M. xenopi arthritis before chronic monoarthritis and before the development of irreversible joint damage.</description><subject>Adult</subject><subject>Ankle Joint - microbiology</subject><subject>Antibiotics</subject><subject>Arthritis</subject><subject>Arthritis, Infectious - microbiology</subject><subject>Arthroplasty, Replacement, Knee - adverse effects</subject><subject>Arthroscopy</subject><subject>Arthroscopy - adverse effects</subject><subject>Articles and Commentaries</subject><subject>Biological and medical sciences</subject><subject>Bones</subject><subject>Cross Infection - microbiology</subject><subject>Discitis</subject><subject>Diseases of the osteoarticular system</subject><subject>Diskectomy, Percutaneous - adverse effects</subject><subject>Epidemiology</subject><subject>Female</subject><subject>France</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Joints</subject><subject>Knee Joint - microbiology</subject><subject>Knees</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>Mycobacterium Infections, Nontuberculous - microbiology</subject><subject>Mycobacterium Infections, Nontuberculous - therapy</subject><subject>Mycobacterium xenopi</subject><subject>Pathogens</subject><subject>Retrospective Studies</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V2LEzEUBuAgivuh_gKRIOjdaM7ke-9q190VK6KrIN6ETOYMprYzNcnI9t87pWVXvPEqgfPwkryHkCfAXgEz6rVkWnG4R45Bcl0paeH-dGfSVMJwc0ROcl4yBmCYfEiOQFnDFbPH5NMslR8plpjp-Yi0DPTDNgyNDwVTHNf0BvthE8_ojH7Gkoa8wVDib6TXZWy3dOiopnOfMdPY04vk-4CPyIPOrzI-Ppyn5OvF2y_zq2rx8fLdfLaogqhFqTSiai1voQamRDASVDAmdAEZbzRTNWMtQCekaoXmbcO1QGOtlaJhDRc1PyUv97mbNPwaMRe3jjngauV7HMbslDFKKcH_C2tWKy44m-Dzf-ByGFM_fcLVYO0UVv-VFqY2csLObVJc-7R1wNxuFW6_igk-O6SNzRrbO3bofgIvDsDn4Ffdrr2Y75wBIySIyT3du2UuQ7qdC2Ekg92rq_045oI3t2OffjqluZbu6tt3t6gv34C85u49_wMOcKSf</recordid><startdate>20061015</startdate><enddate>20061015</enddate><creator>Salliot, Carine</creator><creator>Desplaces, Nicole</creator><creator>Boisrenoult, Philippe</creator><creator>Koeger, Anne Claude</creator><creator>Beaufils, Philippe</creator><creator>Vincent, Véronique</creator><creator>Mamoudy, Patrick</creator><creator>Ziza, Jean-Marc</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20061015</creationdate><title>Arthritis Due to Mycobacterium xenopi: A Retrospective Study of 7 Cases in France</title><author>Salliot, Carine ; Desplaces, Nicole ; Boisrenoult, Philippe ; Koeger, Anne Claude ; Beaufils, Philippe ; Vincent, Véronique ; Mamoudy, Patrick ; Ziza, Jean-Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-7ee6d93d121064c8516c88cfce03b706200d11f456d473db374e899954b0b3423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Ankle Joint - microbiology</topic><topic>Antibiotics</topic><topic>Arthritis</topic><topic>Arthritis, Infectious - microbiology</topic><topic>Arthroplasty, Replacement, Knee - adverse effects</topic><topic>Arthroscopy</topic><topic>Arthroscopy - adverse effects</topic><topic>Articles and Commentaries</topic><topic>Biological and medical sciences</topic><topic>Bones</topic><topic>Cross Infection - microbiology</topic><topic>Discitis</topic><topic>Diseases of the osteoarticular system</topic><topic>Diskectomy, Percutaneous - adverse effects</topic><topic>Epidemiology</topic><topic>Female</topic><topic>France</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Joints</topic><topic>Knee Joint - microbiology</topic><topic>Knees</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous. Osteoarticular involvement in other diseases</topic><topic>Mycobacterium Infections, Nontuberculous - microbiology</topic><topic>Mycobacterium Infections, Nontuberculous - therapy</topic><topic>Mycobacterium xenopi</topic><topic>Pathogens</topic><topic>Retrospective Studies</topic><topic>Rheumatology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salliot, Carine</creatorcontrib><creatorcontrib>Desplaces, Nicole</creatorcontrib><creatorcontrib>Boisrenoult, Philippe</creatorcontrib><creatorcontrib>Koeger, Anne Claude</creatorcontrib><creatorcontrib>Beaufils, Philippe</creatorcontrib><creatorcontrib>Vincent, Véronique</creatorcontrib><creatorcontrib>Mamoudy, Patrick</creatorcontrib><creatorcontrib>Ziza, Jean-Marc</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salliot, Carine</au><au>Desplaces, Nicole</au><au>Boisrenoult, Philippe</au><au>Koeger, Anne Claude</au><au>Beaufils, Philippe</au><au>Vincent, Véronique</au><au>Mamoudy, Patrick</au><au>Ziza, Jean-Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arthritis Due to Mycobacterium xenopi: A Retrospective Study of 7 Cases in France</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>2006-10-15</date><risdate>2006</risdate><volume>43</volume><issue>8</issue><spage>987</spage><epage>993</epage><pages>987-993</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Background. Mycobacterium xenopi is a nontuberculous mycobacterium responsible for opportunistic and nosocomial infections, chiefly of the lung; few cases of bone and joint infection have been reported. From July 1989 through May 1993, an outbreak of 58 cases of nosocomial discitis due to M. xenopi infection following percutaneous nucleotomy occurred in a French hospital. Peripheral M. xenopi arthritis seems exceedingly rare. We conducted a study to assess the epidemiological and clinical patterns of M. xenopi arthritis. Methods. We retrospectively reviewed cases of M. xenopi arthritis reported from May 1993 through October 2004. Results. We identified 7 cases, all of which occurred after invasive surgical procedures were performed on the affected joint, suggesting a nosocomial pattern of infection. Two patients may have been contaminated at the hospital where the M. xenopi discitis outbreak occurred. No source was identified in the other 5 patients. Despite the probable nosocomial nature of the infections, the diagnosis was delayed (mean time until diagnosis, 50 months). Repeated collection of deep tissue specimens for bacteriological analysis seemed crucial to the diagnosis. The treatment relied on combination antimicrobial therapy and surgery. Among 11 cases of M. xenopi osteoarticular infection reported in the literature from 1975 to 2005, (arthritis in 9 cases and osteitis in 2), none were nosocomial. Conclusion. A high index of suspicion should be maintained to ensure the diagnosis of M. xenopi arthritis before chronic monoarthritis and before the development of irreversible joint damage.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>16983609</pmid><doi>10.1086/507631</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Ankle Joint - microbiology Antibiotics Arthritis Arthritis, Infectious - microbiology Arthroplasty, Replacement, Knee - adverse effects Arthroscopy Arthroscopy - adverse effects Articles and Commentaries Biological and medical sciences Bones Cross Infection - microbiology Discitis Diseases of the osteoarticular system Diskectomy, Percutaneous - adverse effects Epidemiology Female France Humans Immunotherapy Infections Infectious diseases Joints Knee Joint - microbiology Knees Male Medical sciences Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Mycobacterium Infections, Nontuberculous - microbiology Mycobacterium Infections, Nontuberculous - therapy Mycobacterium xenopi Pathogens Retrospective Studies Rheumatology Risk Factors |
| title | Arthritis Due to Mycobacterium xenopi: A Retrospective Study of 7 Cases in France |
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