Evaluation of constant current alternating current iontophoresis for transdermal drug delivery

Previous studies in our laboratory have demonstrated that alternating current (AC) iontophoresis can significantly decrease skin electric resistance and enhance the transport of charged permeants across skin. Flux variability of neutral permeants during AC iontophoresis was also found to be less tha...

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Veröffentlicht in:	Journal of controlled release 2005-12, Vol.110 (1), p.141-150
Hauptverfasser:	Yan, Guang, Li, S. Kevin, Higuchi, William I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Alternating current Biological and medical sciences Diffusion Chambers, Culture Direct current Drug Delivery Systems Electric Conductivity Electric Impedance Epidermis - metabolism General pharmacology Human epidermal membrane Humans In Vitro Techniques Iontophoresis Iontophoresis - methods Mannitol - administration & dosage Mannitol - chemistry Mannitol - metabolism Medical sciences Osmolar Concentration Permeability Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Skin Absorption Tetraethylammonium - administration & dosage Tetraethylammonium - chemistry Tetraethylammonium - metabolism Transdermal Transport
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