Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163
OBJECTIVE:Soluble CD163 (sCD163) is a new macrophage-specific serum marker. This study investigated sCD163 and other markers of macrophage activation (neopterin, ferritin, transcobalamin, and soluble urokinase plasminogen activator receptor [suPAR]) as prognostic factors in patients with pneumococca...
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| Veröffentlicht in: | Critical care medicine 2006-10, Vol.34 (10), p.2561-2566 |
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| creator | Møller, Holger Jon Moestrup, Søren K Weis, Nina Wejse, Christian Nielsen, Henrik Pedersen, Svend Stenvang Attermann, Jørn Nexø, Ebba Kronborg, Gitte |
| description | OBJECTIVE:Soluble CD163 (sCD163) is a new macrophage-specific serum marker. This study investigated sCD163 and other markers of macrophage activation (neopterin, ferritin, transcobalamin, and soluble urokinase plasminogen activator receptor [suPAR]) as prognostic factors in patients with pneumococcal bacteremia.
DESIGN:Observational cohort study.
SETTING:Five university hospitals in Denmark.
PATIENTS:A total of 133 patients with Streptococcus pneumoniae bacteremia (positive blood culture) and 133 age- and gender-matched controls.
INTERVENTIONS:Samples were collected for biochemical analyses at the time of first positive blood culture.
MEASUREMENTS AND MAIN RESULTS:sCD163 was highly correlated with other macrophage markers and was significantly elevated (median [25–75 percentiles], 4.6 mg/L [2.8–8.9]) compared with healthy controls (2.7 mg/L [2.1–3.3], p < .0001). Increased levels were observed in patients who needed intensive care (hemodialysis, p = .0011; hypotension, p = .0014; mechanical ventilation, p = .0019). Significantly lower levels of sCD163, ferritin, transcobalamin, and suPAR (but not C-reactive protein) were measured in patients ≥75 yrs. In patients |
| doi_str_mv | 10.1097/01.CCM.0000239120.32490.AB |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68866179</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68866179</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4588-61e3ef95327e6b37aeac93ef053f3a70931dcf1f1fe3775c277f69e1cc89850c3</originalsourceid><addsrcrecordid>eNpFkF1v0zAUhi0EYmXwF5CFBHcJ58SJP3bXBTaQNsEF3CFZrntCw5K4s5tN-_e4a6Xaki1bzzmvzsPYB4QSwajPgGXb3paQVyUMVlCKqjZQLi9fsAU2AgqojHjJFgAGClEbccbepPQPAOtGidfsDKXBBrFasD-3zsew3bi_xBPFeeSji3cUE-8nvp1oHoMP3ruBr5zfUaSxdxf8Z6R173d9mHjoeJrjQ_-wR554CsO8Goi3X1CKt-xV54ZE7473Oft99fVX-624-XH9vV3eFL5utC4kkqDONKJSJFdCOXLe5B9oRCecAiNw7TvMm4RSja-U6qQh9F4b3YAX5-zToe82hvuZ0s6OffI0DG6iMCcrtZYSlcngxQHMM6cUqbPb2OeBnyyC3bu1gDa7tSe39tmtXV7m4vfHlHk10vpUepSZgY9HwKVsrItu8n06cRqF0TVkrj5wj2HIStPdMD9StBtyw27zHJ0zZVEBSNy_iv2hxX9kKJHn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68866179</pqid></control><display><type>article</type><title>Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Møller, Holger Jon ; Moestrup, Søren K ; Weis, Nina ; Wejse, Christian ; Nielsen, Henrik ; Pedersen, Svend Stenvang ; Attermann, Jørn ; Nexø, Ebba ; Kronborg, Gitte</creator><creatorcontrib>Møller, Holger Jon ; Moestrup, Søren K ; Weis, Nina ; Wejse, Christian ; Nielsen, Henrik ; Pedersen, Svend Stenvang ; Attermann, Jørn ; Nexø, Ebba ; Kronborg, Gitte</creatorcontrib><description>OBJECTIVE:Soluble CD163 (sCD163) is a new macrophage-specific serum marker. This study investigated sCD163 and other markers of macrophage activation (neopterin, ferritin, transcobalamin, and soluble urokinase plasminogen activator receptor [suPAR]) as prognostic factors in patients with pneumococcal bacteremia.
DESIGN:Observational cohort study.
SETTING:Five university hospitals in Denmark.
PATIENTS:A total of 133 patients with Streptococcus pneumoniae bacteremia (positive blood culture) and 133 age- and gender-matched controls.
INTERVENTIONS:Samples were collected for biochemical analyses at the time of first positive blood culture.
MEASUREMENTS AND MAIN RESULTS:sCD163 was highly correlated with other macrophage markers and was significantly elevated (median [25–75 percentiles], 4.6 mg/L [2.8–8.9]) compared with healthy controls (2.7 mg/L [2.1–3.3], p < .0001). Increased levels were observed in patients who needed intensive care (hemodialysis, p = .0011; hypotension, p = .0014; mechanical ventilation, p = .0019). Significantly lower levels of sCD163, ferritin, transcobalamin, and suPAR (but not C-reactive protein) were measured in patients ≥75 yrs. In patients <75 yrs, all macrophage markers were increased in patients who died from their infection compared with survivors, whereas no change was observed in any of the markers in the very old age. At cutoff levels of 9.5 mg/L (sCD163) and 1650 nmol/L (C-reactive protein), the relative risk for fatal outcome in patients <75 yrs was 10.1 (95% confidence interval 3.4–31.0) and 7.0 (95% confidence interval 2.4–21.6) for sCD163 and C-reactive protein, respectively. In a multivariate logistic regression model for patients <75 yrs, ferritin, transcobalamin, neopterin, and suPAR contained no significant information on the probability of survival when sCD163 and CRP were known (p = .25).
CONCLUSIONS:Macrophage marker response in pneumococcal bacteremia was compromised in old age. In patients <75 yrs old, sCD163 was superior to other markers, including C-reactive protein, in predicting fatal disease outcome.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/01.CCM.0000239120.32490.AB</identifier><identifier>PMID: 16915112</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antigens, CD - blood ; Antigens, Differentiation, Myelomonocytic - blood ; Bacteremia - blood ; Bacteremia - diagnosis ; Biological and medical sciences ; Biomarkers - blood ; Case-Control Studies ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Emergency and intensive care: infection, septic shock ; Female ; Humans ; Intensive care medicine ; Logistic Models ; Macrophage Activation ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Pneumococcal Infections - blood ; Pneumococcal Infections - diagnosis ; Prognosis ; Receptors, Cell Surface - blood ; Sensitivity and Specificity ; Streptococcus pneumoniae ; Survival Analysis</subject><ispartof>Critical care medicine, 2006-10, Vol.34 (10), p.2561-2566</ispartof><rights>2006 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4588-61e3ef95327e6b37aeac93ef053f3a70931dcf1f1fe3775c277f69e1cc89850c3</citedby><cites>FETCH-LOGICAL-c4588-61e3ef95327e6b37aeac93ef053f3a70931dcf1f1fe3775c277f69e1cc89850c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18139840$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16915112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Møller, Holger Jon</creatorcontrib><creatorcontrib>Moestrup, Søren K</creatorcontrib><creatorcontrib>Weis, Nina</creatorcontrib><creatorcontrib>Wejse, Christian</creatorcontrib><creatorcontrib>Nielsen, Henrik</creatorcontrib><creatorcontrib>Pedersen, Svend Stenvang</creatorcontrib><creatorcontrib>Attermann, Jørn</creatorcontrib><creatorcontrib>Nexø, Ebba</creatorcontrib><creatorcontrib>Kronborg, Gitte</creatorcontrib><title>Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>OBJECTIVE:Soluble CD163 (sCD163) is a new macrophage-specific serum marker. This study investigated sCD163 and other markers of macrophage activation (neopterin, ferritin, transcobalamin, and soluble urokinase plasminogen activator receptor [suPAR]) as prognostic factors in patients with pneumococcal bacteremia.
DESIGN:Observational cohort study.
SETTING:Five university hospitals in Denmark.
PATIENTS:A total of 133 patients with Streptococcus pneumoniae bacteremia (positive blood culture) and 133 age- and gender-matched controls.
INTERVENTIONS:Samples were collected for biochemical analyses at the time of first positive blood culture.
MEASUREMENTS AND MAIN RESULTS:sCD163 was highly correlated with other macrophage markers and was significantly elevated (median [25–75 percentiles], 4.6 mg/L [2.8–8.9]) compared with healthy controls (2.7 mg/L [2.1–3.3], p < .0001). Increased levels were observed in patients who needed intensive care (hemodialysis, p = .0011; hypotension, p = .0014; mechanical ventilation, p = .0019). Significantly lower levels of sCD163, ferritin, transcobalamin, and suPAR (but not C-reactive protein) were measured in patients ≥75 yrs. In patients <75 yrs, all macrophage markers were increased in patients who died from their infection compared with survivors, whereas no change was observed in any of the markers in the very old age. At cutoff levels of 9.5 mg/L (sCD163) and 1650 nmol/L (C-reactive protein), the relative risk for fatal outcome in patients <75 yrs was 10.1 (95% confidence interval 3.4–31.0) and 7.0 (95% confidence interval 2.4–21.6) for sCD163 and C-reactive protein, respectively. In a multivariate logistic regression model for patients <75 yrs, ferritin, transcobalamin, neopterin, and suPAR contained no significant information on the probability of survival when sCD163 and CRP were known (p = .25).
CONCLUSIONS:Macrophage marker response in pneumococcal bacteremia was compromised in old age. In patients <75 yrs old, sCD163 was superior to other markers, including C-reactive protein, in predicting fatal disease outcome.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antigens, CD - blood</subject><subject>Antigens, Differentiation, Myelomonocytic - blood</subject><subject>Bacteremia - blood</subject><subject>Bacteremia - diagnosis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Female</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Logistic Models</subject><subject>Macrophage Activation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Pneumococcal Infections - blood</subject><subject>Pneumococcal Infections - diagnosis</subject><subject>Prognosis</subject><subject>Receptors, Cell Surface - blood</subject><subject>Sensitivity and Specificity</subject><subject>Streptococcus pneumoniae</subject><subject>Survival Analysis</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1v0zAUhi0EYmXwF5CFBHcJ58SJP3bXBTaQNsEF3CFZrntCw5K4s5tN-_e4a6Xaki1bzzmvzsPYB4QSwajPgGXb3paQVyUMVlCKqjZQLi9fsAU2AgqojHjJFgAGClEbccbepPQPAOtGidfsDKXBBrFasD-3zsew3bi_xBPFeeSji3cUE-8nvp1oHoMP3ruBr5zfUaSxdxf8Z6R173d9mHjoeJrjQ_-wR554CsO8Goi3X1CKt-xV54ZE7473Oft99fVX-624-XH9vV3eFL5utC4kkqDONKJSJFdCOXLe5B9oRCecAiNw7TvMm4RSja-U6qQh9F4b3YAX5-zToe82hvuZ0s6OffI0DG6iMCcrtZYSlcngxQHMM6cUqbPb2OeBnyyC3bu1gDa7tSe39tmtXV7m4vfHlHk10vpUepSZgY9HwKVsrItu8n06cRqF0TVkrj5wj2HIStPdMD9StBtyw27zHJ0zZVEBSNy_iv2hxX9kKJHn</recordid><startdate>200610</startdate><enddate>200610</enddate><creator>Møller, Holger Jon</creator><creator>Moestrup, Søren K</creator><creator>Weis, Nina</creator><creator>Wejse, Christian</creator><creator>Nielsen, Henrik</creator><creator>Pedersen, Svend Stenvang</creator><creator>Attermann, Jørn</creator><creator>Nexø, Ebba</creator><creator>Kronborg, Gitte</creator><general>by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200610</creationdate><title>Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163</title><author>Møller, Holger Jon ; Moestrup, Søren K ; Weis, Nina ; Wejse, Christian ; Nielsen, Henrik ; Pedersen, Svend Stenvang ; Attermann, Jørn ; Nexø, Ebba ; Kronborg, Gitte</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4588-61e3ef95327e6b37aeac93ef053f3a70931dcf1f1fe3775c277f69e1cc89850c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antigens, CD - blood</topic><topic>Antigens, Differentiation, Myelomonocytic - blood</topic><topic>Bacteremia - blood</topic><topic>Bacteremia - diagnosis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</topic><topic>Emergency and intensive care: infection, septic shock</topic><topic>Female</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Logistic Models</topic><topic>Macrophage Activation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Pneumococcal Infections - blood</topic><topic>Pneumococcal Infections - diagnosis</topic><topic>Prognosis</topic><topic>Receptors, Cell Surface - blood</topic><topic>Sensitivity and Specificity</topic><topic>Streptococcus pneumoniae</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Møller, Holger Jon</creatorcontrib><creatorcontrib>Moestrup, Søren K</creatorcontrib><creatorcontrib>Weis, Nina</creatorcontrib><creatorcontrib>Wejse, Christian</creatorcontrib><creatorcontrib>Nielsen, Henrik</creatorcontrib><creatorcontrib>Pedersen, Svend Stenvang</creatorcontrib><creatorcontrib>Attermann, Jørn</creatorcontrib><creatorcontrib>Nexø, Ebba</creatorcontrib><creatorcontrib>Kronborg, Gitte</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Møller, Holger Jon</au><au>Moestrup, Søren K</au><au>Weis, Nina</au><au>Wejse, Christian</au><au>Nielsen, Henrik</au><au>Pedersen, Svend Stenvang</au><au>Attermann, Jørn</au><au>Nexø, Ebba</au><au>Kronborg, Gitte</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>2006-10</date><risdate>2006</risdate><volume>34</volume><issue>10</issue><spage>2561</spage><epage>2566</epage><pages>2561-2566</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>OBJECTIVE:Soluble CD163 (sCD163) is a new macrophage-specific serum marker. This study investigated sCD163 and other markers of macrophage activation (neopterin, ferritin, transcobalamin, and soluble urokinase plasminogen activator receptor [suPAR]) as prognostic factors in patients with pneumococcal bacteremia.
DESIGN:Observational cohort study.
SETTING:Five university hospitals in Denmark.
PATIENTS:A total of 133 patients with Streptococcus pneumoniae bacteremia (positive blood culture) and 133 age- and gender-matched controls.
INTERVENTIONS:Samples were collected for biochemical analyses at the time of first positive blood culture.
MEASUREMENTS AND MAIN RESULTS:sCD163 was highly correlated with other macrophage markers and was significantly elevated (median [25–75 percentiles], 4.6 mg/L [2.8–8.9]) compared with healthy controls (2.7 mg/L [2.1–3.3], p < .0001). Increased levels were observed in patients who needed intensive care (hemodialysis, p = .0011; hypotension, p = .0014; mechanical ventilation, p = .0019). Significantly lower levels of sCD163, ferritin, transcobalamin, and suPAR (but not C-reactive protein) were measured in patients ≥75 yrs. In patients <75 yrs, all macrophage markers were increased in patients who died from their infection compared with survivors, whereas no change was observed in any of the markers in the very old age. At cutoff levels of 9.5 mg/L (sCD163) and 1650 nmol/L (C-reactive protein), the relative risk for fatal outcome in patients <75 yrs was 10.1 (95% confidence interval 3.4–31.0) and 7.0 (95% confidence interval 2.4–21.6) for sCD163 and C-reactive protein, respectively. In a multivariate logistic regression model for patients <75 yrs, ferritin, transcobalamin, neopterin, and suPAR contained no significant information on the probability of survival when sCD163 and CRP were known (p = .25).
CONCLUSIONS:Macrophage marker response in pneumococcal bacteremia was compromised in old age. In patients <75 yrs old, sCD163 was superior to other markers, including C-reactive protein, in predicting fatal disease outcome.</abstract><cop>Hagerstown, MD</cop><pub>by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</pub><pmid>16915112</pmid><doi>10.1097/01.CCM.0000239120.32490.AB</doi><tpages>6</tpages></addata></record> |
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| ispartof | Critical care medicine, 2006-10, Vol.34 (10), p.2561-2566 |
| issn | 0090-3493 1530-0293 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Age Factors Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, CD - blood Antigens, Differentiation, Myelomonocytic - blood Bacteremia - blood Bacteremia - diagnosis Biological and medical sciences Biomarkers - blood Case-Control Studies Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Emergency and intensive care: infection, septic shock Female Humans Intensive care medicine Logistic Models Macrophage Activation Male Medical sciences Middle Aged Multivariate Analysis Pneumococcal Infections - blood Pneumococcal Infections - diagnosis Prognosis Receptors, Cell Surface - blood Sensitivity and Specificity Streptococcus pneumoniae Survival Analysis |
| title | Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163 |
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