A novel system for efficient gene transfer into primary human hepatocytes via cell-permeable hepatitis B virus-like particle

Protein transduction domains (PTDs) have been used to deliver a variety of biologically active cargo across cellular membranes. However the potential of PTDs to mediate transport of nanoparticular structures into the cytoplasm bypassing the endosomal compartment remains unclear. Cell-permeable virus...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2005-12, Vol.42 (6), p.1300-1309
Hauptverfasser:	BRANDENBURG, Boerries, STOCKL, Lars, GUTZEIT, Cindy, ROOS, Martin, LUPBERGER, Joachim, SCHWARTLANDER, Ruth, GELDERBLOM, Hans, SAUER, Igor M, HOFSCHNEIDER, Peter Hans, HILDT, Eberhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cells, Cultured Gastroenterology. Liver. Pancreas. Abdomen Gene Transfer Techniques Genetic Therapy Hepatitis B virus - genetics Hepatocytes - metabolism Humans Medical sciences Nucleocapsid - metabolism Permeability Virion - genetics Virus Assembly
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