Treatment of post-hematopoietic stem cell transplantation hemorrhagic cystitis with intravesicular sodium hyaluronate

Hemorrhagic cystitis (HC) is a well-known complication of HSCT. Its overall incidence has been reported to vary from 7-68%. The spectrum of clinical presentation varies from asymptomatic microhematuria to life-threatening bleeding. Sodium hyaluronate is a glycosaminoglycan present on the bladder muc...

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Veröffentlicht in:Bone marrow transplantation (Basingstoke) 2006-10, Vol.38 (7), p.507-511
Hauptverfasser: MIODOSKY, M, ABDUL-HAI, A, SLAVIN, S, SHAPIRA, M. Y, TSIRIGOTIS, P, OR, R, BITAN, M, RESNICK, I. B, GESUNDHEIT, B, ZILBERMAN, I, IOFFE, L, LEUBOVIC, A
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container_end_page 511
container_issue 7
container_start_page 507
container_title Bone marrow transplantation (Basingstoke)
container_volume 38
creator MIODOSKY, M
ABDUL-HAI, A
SLAVIN, S
SHAPIRA, M. Y
TSIRIGOTIS, P
OR, R
BITAN, M
RESNICK, I. B
GESUNDHEIT, B
ZILBERMAN, I
IOFFE, L
LEUBOVIC, A
description Hemorrhagic cystitis (HC) is a well-known complication of HSCT. Its overall incidence has been reported to vary from 7-68%. The spectrum of clinical presentation varies from asymptomatic microhematuria to life-threatening bleeding. Sodium hyaluronate is a glycosaminoglycan present on the bladder mucosa, which serves as an important protective substance against uroepithelial damage. Preparations of this component have been shown to be effective in the treatment of interstitial cystitis. We report our experience in the treatment of post-transplant HC with intravesical instillation of sodium hyaluronate. Five out of the seven patients included in this study achieved complete response, while one patient had only partial response. Sodium hyaluronate administration was not associated with any local or systemic adverse effects. We consider that the results of our study are promising and the efficacy of sodium hyaluronate in the treatment of post-transplant HC should be tested in larger cohorts of patients.
doi_str_mv 10.1038/sj.bmt.1705474
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Graft versus host reaction ; Cystitis ; Cystitis - drug therapy ; Cystitis - etiology ; Diagnosis ; Dosage and administration ; Drug therapy ; Female ; Glycosaminoglycans ; Graft vs Host Disease - complications ; Health aspects ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic stem cells ; Hematuria - drug therapy ; Hematuria - etiology ; Hemorrhage ; Hemorrhagic cystitis ; Humans ; Hyaluronic acid ; Hyaluronic Acid - administration &amp; dosage ; Male ; Medical sciences ; Methods ; Mucosa ; Nephrology. Urinary tract diseases ; Patients ; Physiological aspects ; Risk factors ; Sodium ; Sodium hyaluronate ; Stem cell transplantation ; Stem cells ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Transplantation Conditioning - adverse effects ; Transplants &amp; implants ; Treatment Outcome ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. 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Preparations of this component have been shown to be effective in the treatment of interstitial cystitis. We report our experience in the treatment of post-transplant HC with intravesical instillation of sodium hyaluronate. Five out of the seven patients included in this study achieved complete response, while one patient had only partial response. Sodium hyaluronate administration was not associated with any local or systemic adverse effects. We consider that the results of our study are promising and the efficacy of sodium hyaluronate in the treatment of post-transplant HC should be tested in larger cohorts of patients.</description><subject>Administration, Intravesical</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Cystitis</subject><subject>Cystitis - drug therapy</subject><subject>Cystitis - etiology</subject><subject>Diagnosis</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Glycosaminoglycans</subject><subject>Graft vs Host Disease - complications</subject><subject>Health aspects</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic stem cells</subject><subject>Hematuria - drug therapy</subject><subject>Hematuria - etiology</subject><subject>Hemorrhage</subject><subject>Hemorrhagic cystitis</subject><subject>Humans</subject><subject>Hyaluronic acid</subject><subject>Hyaluronic Acid - administration &amp; dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methods</subject><subject>Mucosa</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Risk factors</subject><subject>Sodium</subject><subject>Sodium hyaluronate</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Transplantation</subject><subject>Transplantation Conditioning - adverse effects</subject><subject>Transplants &amp; implants</subject><subject>Treatment Outcome</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. 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subjects Administration, Intravesical
Adolescent
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Bone marrow, stem cells transplantation. Graft versus host reaction
Cystitis
Cystitis - drug therapy
Cystitis - etiology
Diagnosis
Dosage and administration
Drug therapy
Female
Glycosaminoglycans
Graft vs Host Disease - complications
Health aspects
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic stem cells
Hematuria - drug therapy
Hematuria - etiology
Hemorrhage
Hemorrhagic cystitis
Humans
Hyaluronic acid
Hyaluronic Acid - administration & dosage
Male
Medical sciences
Methods
Mucosa
Nephrology. Urinary tract diseases
Patients
Physiological aspects
Risk factors
Sodium
Sodium hyaluronate
Stem cell transplantation
Stem cells
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplantation
Transplantation Conditioning - adverse effects
Transplants & implants
Treatment Outcome
Urinary system involvement in other diseases. Miscellaneous
Urinary tract. Prostate gland
title Treatment of post-hematopoietic stem cell transplantation hemorrhagic cystitis with intravesicular sodium hyaluronate
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