Treatment of post-hematopoietic stem cell transplantation hemorrhagic cystitis with intravesicular sodium hyaluronate
Hemorrhagic cystitis (HC) is a well-known complication of HSCT. Its overall incidence has been reported to vary from 7-68%. The spectrum of clinical presentation varies from asymptomatic microhematuria to life-threatening bleeding. Sodium hyaluronate is a glycosaminoglycan present on the bladder muc...
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creator | MIODOSKY, M ABDUL-HAI, A SLAVIN, S SHAPIRA, M. Y TSIRIGOTIS, P OR, R BITAN, M RESNICK, I. B GESUNDHEIT, B ZILBERMAN, I IOFFE, L LEUBOVIC, A |
description | Hemorrhagic cystitis (HC) is a well-known complication of HSCT. Its overall incidence has been reported to vary from 7-68%. The spectrum of clinical presentation varies from asymptomatic microhematuria to life-threatening bleeding. Sodium hyaluronate is a glycosaminoglycan present on the bladder mucosa, which serves as an important protective substance against uroepithelial damage. Preparations of this component have been shown to be effective in the treatment of interstitial cystitis. We report our experience in the treatment of post-transplant HC with intravesical instillation of sodium hyaluronate. Five out of the seven patients included in this study achieved complete response, while one patient had only partial response. Sodium hyaluronate administration was not associated with any local or systemic adverse effects. We consider that the results of our study are promising and the efficacy of sodium hyaluronate in the treatment of post-transplant HC should be tested in larger cohorts of patients. |
doi_str_mv | 10.1038/sj.bmt.1705474 |
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Y ; TSIRIGOTIS, P ; OR, R ; BITAN, M ; RESNICK, I. B ; GESUNDHEIT, B ; ZILBERMAN, I ; IOFFE, L ; LEUBOVIC, A</creator><creatorcontrib>MIODOSKY, M ; ABDUL-HAI, A ; SLAVIN, S ; SHAPIRA, M. Y ; TSIRIGOTIS, P ; OR, R ; BITAN, M ; RESNICK, I. B ; GESUNDHEIT, B ; ZILBERMAN, I ; IOFFE, L ; LEUBOVIC, A</creatorcontrib><description>Hemorrhagic cystitis (HC) is a well-known complication of HSCT. Its overall incidence has been reported to vary from 7-68%. The spectrum of clinical presentation varies from asymptomatic microhematuria to life-threatening bleeding. Sodium hyaluronate is a glycosaminoglycan present on the bladder mucosa, which serves as an important protective substance against uroepithelial damage. Preparations of this component have been shown to be effective in the treatment of interstitial cystitis. We report our experience in the treatment of post-transplant HC with intravesical instillation of sodium hyaluronate. Five out of the seven patients included in this study achieved complete response, while one patient had only partial response. Sodium hyaluronate administration was not associated with any local or systemic adverse effects. We consider that the results of our study are promising and the efficacy of sodium hyaluronate in the treatment of post-transplant HC should be tested in larger cohorts of patients.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/sj.bmt.1705474</identifier><identifier>PMID: 16921402</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Administration, Intravesical ; Adolescent ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Cystitis ; Cystitis - drug therapy ; Cystitis - etiology ; Diagnosis ; Dosage and administration ; Drug therapy ; Female ; Glycosaminoglycans ; Graft vs Host Disease - complications ; Health aspects ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic stem cells ; Hematuria - drug therapy ; Hematuria - etiology ; Hemorrhage ; Hemorrhagic cystitis ; Humans ; Hyaluronic acid ; Hyaluronic Acid - administration & dosage ; Male ; Medical sciences ; Methods ; Mucosa ; Nephrology. Urinary tract diseases ; Patients ; Physiological aspects ; Risk factors ; Sodium ; Sodium hyaluronate ; Stem cell transplantation ; Stem cells ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Transplantation Conditioning - adverse effects ; Transplants & implants ; Treatment Outcome ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland</subject><ispartof>Bone marrow transplantation (Basingstoke), 2006-10, Vol.38 (7), p.507-511</ispartof><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Oct 2006</rights><rights>Nature Publishing Group 2006.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-547a56782980a11c61caa3e9364da79000591deb756dbba5cda2d508402634a33</citedby><cites>FETCH-LOGICAL-c547t-547a56782980a11c61caa3e9364da79000591deb756dbba5cda2d508402634a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18169261$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16921402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIODOSKY, M</creatorcontrib><creatorcontrib>ABDUL-HAI, A</creatorcontrib><creatorcontrib>SLAVIN, S</creatorcontrib><creatorcontrib>SHAPIRA, M. Y</creatorcontrib><creatorcontrib>TSIRIGOTIS, P</creatorcontrib><creatorcontrib>OR, R</creatorcontrib><creatorcontrib>BITAN, M</creatorcontrib><creatorcontrib>RESNICK, I. B</creatorcontrib><creatorcontrib>GESUNDHEIT, B</creatorcontrib><creatorcontrib>ZILBERMAN, I</creatorcontrib><creatorcontrib>IOFFE, L</creatorcontrib><creatorcontrib>LEUBOVIC, A</creatorcontrib><title>Treatment of post-hematopoietic stem cell transplantation hemorrhagic cystitis with intravesicular sodium hyaluronate</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><description>Hemorrhagic cystitis (HC) is a well-known complication of HSCT. Its overall incidence has been reported to vary from 7-68%. The spectrum of clinical presentation varies from asymptomatic microhematuria to life-threatening bleeding. Sodium hyaluronate is a glycosaminoglycan present on the bladder mucosa, which serves as an important protective substance against uroepithelial damage. Preparations of this component have been shown to be effective in the treatment of interstitial cystitis. We report our experience in the treatment of post-transplant HC with intravesical instillation of sodium hyaluronate. Five out of the seven patients included in this study achieved complete response, while one patient had only partial response. Sodium hyaluronate administration was not associated with any local or systemic adverse effects. We consider that the results of our study are promising and the efficacy of sodium hyaluronate in the treatment of post-transplant HC should be tested in larger cohorts of patients.</description><subject>Administration, Intravesical</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Cystitis</subject><subject>Cystitis - drug therapy</subject><subject>Cystitis - etiology</subject><subject>Diagnosis</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Glycosaminoglycans</subject><subject>Graft vs Host Disease - complications</subject><subject>Health aspects</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic stem cells</subject><subject>Hematuria - drug therapy</subject><subject>Hematuria - etiology</subject><subject>Hemorrhage</subject><subject>Hemorrhagic cystitis</subject><subject>Humans</subject><subject>Hyaluronic acid</subject><subject>Hyaluronic Acid - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methods</subject><subject>Mucosa</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Risk factors</subject><subject>Sodium</subject><subject>Sodium hyaluronate</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Transplantation</subject><subject>Transplantation Conditioning - adverse effects</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. 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Y</au><au>TSIRIGOTIS, P</au><au>OR, R</au><au>BITAN, M</au><au>RESNICK, I. B</au><au>GESUNDHEIT, B</au><au>ZILBERMAN, I</au><au>IOFFE, L</au><au>LEUBOVIC, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of post-hematopoietic stem cell transplantation hemorrhagic cystitis with intravesicular sodium hyaluronate</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><addtitle>Bone Marrow Transplant</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>38</volume><issue>7</issue><spage>507</spage><epage>511</epage><pages>507-511</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><coden>BMTRE9</coden><abstract>Hemorrhagic cystitis (HC) is a well-known complication of HSCT. Its overall incidence has been reported to vary from 7-68%. The spectrum of clinical presentation varies from asymptomatic microhematuria to life-threatening bleeding. Sodium hyaluronate is a glycosaminoglycan present on the bladder mucosa, which serves as an important protective substance against uroepithelial damage. Preparations of this component have been shown to be effective in the treatment of interstitial cystitis. We report our experience in the treatment of post-transplant HC with intravesical instillation of sodium hyaluronate. Five out of the seven patients included in this study achieved complete response, while one patient had only partial response. Sodium hyaluronate administration was not associated with any local or systemic adverse effects. We consider that the results of our study are promising and the efficacy of sodium hyaluronate in the treatment of post-transplant HC should be tested in larger cohorts of patients.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>16921402</pmid><doi>10.1038/sj.bmt.1705474</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Administration, Intravesical Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction Cystitis Cystitis - drug therapy Cystitis - etiology Diagnosis Dosage and administration Drug therapy Female Glycosaminoglycans Graft vs Host Disease - complications Health aspects Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Hematuria - drug therapy Hematuria - etiology Hemorrhage Hemorrhagic cystitis Humans Hyaluronic acid Hyaluronic Acid - administration & dosage Male Medical sciences Methods Mucosa Nephrology. Urinary tract diseases Patients Physiological aspects Risk factors Sodium Sodium hyaluronate Stem cell transplantation Stem cells Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Conditioning - adverse effects Transplants & implants Treatment Outcome Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland |
title | Treatment of post-hematopoietic stem cell transplantation hemorrhagic cystitis with intravesicular sodium hyaluronate |
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