Identification and Characterization of Keyhole Limpet Hemocyanin N-Glycans Mediating Cross-reactivity with Schistosoma mansoni

Keyhole limpet hemocyanin (KLH) of the mollusc Megathura crenulata is known to serologically cross-react with Schistosoma mansoni glycoconjugates in a carbohydrate-dependent manner. To elucidate the structural basis for this cross-reactivity, KLH glycans were released from tryptic glycopeptides and...

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Veröffentlicht in:	The Journal of biological chemistry 2005-12, Vol.280 (49), p.40731-40748
Hauptverfasser:	Geyer, Hildegard, Wuhrer, Manfred, Resemann, Anja, Geyer, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Specificity Antigens, Helminth - chemistry Antigens, Helminth - immunology Fluorescent Dyes Fructose - analysis Fucose - analysis Galactose - analysis Hemocyanins - chemistry Hemocyanins - immunology Mannose - analysis Megathura crenulata Molecular Structure Mollusca Polysaccharides - chemistry Polysaccharides - immunology Polysaccharides - isolation & purification Schistosoma mansoni Schistosoma mansoni - immunology Serology Spectrometry, Mass, Electrospray Ionization Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Trypsin - metabolism Xylose - analysis
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