Efficacy of Chronic Morphine in a Rat Model of Cancer-Induced Bone Pain: Behavior and in Dorsal Horn Pathophysiology

Morphine is one of the main analgesics in cancer-induced bone pain (CIBP). To investigate the efficacy of morphine in CIBP and alteration in dorsal horn pathophysiology, systemic morphine was administered (3 mg/kg) bi-daily between days 11 and 15 after MRMT-1 carcinoma cell injections (compared with...

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Veröffentlicht in:	The journal of pain 2005-12, Vol.6 (12), p.837-845
Hauptverfasser:	Urch, Catherine E., Donovan-Rodriguez, Tansy, Gordon-Williams, Richard, Bee, Lucy A., Dickenson, Anthony H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Analgesics, Opioid - administration & dosage Anesthesia, Intravenous Animals Behavior, Animal - drug effects Behavior, Animal - physiology Bone Neoplasms - complications Bone Neoplasms - secondary Cancer Disease Models, Animal dorsal horn Dose-Response Relationship, Drug Drug Administration Schedule Injections, Spinal Male Mammary Neoplasms, Experimental - complications Mammary Neoplasms, Experimental - secondary morphine Morphine - administration & dosage Nociceptors - drug effects Nociceptors - physiopathology pain Pain Measurement Pain Threshold - drug effects Pain Threshold - physiology Pain, Intractable - drug therapy Pain, Intractable - etiology Pain, Intractable - physiopathology Physical Stimulation Posterior Horn Cells - drug effects Posterior Horn Cells - physiopathology Rats Rats, Sprague-Dawley Treatment Outcome Tumor Cells, Cultured - transplantation
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