E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients
Hypertension is a main risk factor for atherosclerosis through vascular wall hyperplasia. A recent study reported a new polymorphism (E65 K) in the β 1 subunit (KCNMB1) gene of the Ca 2+ -dependent potassium channel with a protective effect against the severity of diastolic hypertension, but further...
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| Veröffentlicht in: | Journal of human genetics 2005-11, Vol.50 (11), p.604-606 |
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| container_title | Journal of human genetics |
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| creator | Via, Marc Valveny, Neus López-Alomar, Antonio Athanasiadis, Georgios Pintó, Xavier Domingo, Enric Esteban, Esther González-Pérez, Emili Moral, Pedro |
| description | Hypertension is a main risk factor for atherosclerosis through vascular wall hyperplasia. A recent study reported a new polymorphism (E65 K) in the β
1
subunit (KCNMB1) gene of the Ca
2+
-dependent potassium channel with a protective effect against the severity of diastolic hypertension, but further data have lead to conflicting results. In order to ascertain the involvement of the E65 K variant in cardiovascular system regulation, the potential association between this mutation and ischaemic heart disease was assessed through a family-based association study (
n
=302 individuals). Transmission disequilibrium analysis failed to detect any association between this polymorphism and ischaemic heart disease. Although a minor effect cannot be discarded, sample analytical power and negative results do not support a major role for E65 K polymorphism in atherogenic pathologies. |
| doi_str_mv | 10.1007/s10038-005-0298-9 |
| format | Article |
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1
subunit (KCNMB1) gene of the Ca
2+
-dependent potassium channel with a protective effect against the severity of diastolic hypertension, but further data have lead to conflicting results. In order to ascertain the involvement of the E65 K variant in cardiovascular system regulation, the potential association between this mutation and ischaemic heart disease was assessed through a family-based association study (
n
=302 individuals). Transmission disequilibrium analysis failed to detect any association between this polymorphism and ischaemic heart disease. Although a minor effect cannot be discarded, sample analytical power and negative results do not support a major role for E65 K polymorphism in atherogenic pathologies.</description><identifier>ISSN: 1434-5161</identifier><identifier>EISSN: 1435-232X</identifier><identifier>DOI: 10.1007/s10038-005-0298-9</identifier><identifier>PMID: 16155733</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Arteriosclerosis ; Biomedicine ; Calcium ; Cardiovascular disease ; Cardiovascular system ; Coronary artery disease ; DNA Primers ; Gene Expression ; Gene Frequency ; Gene Function ; Gene polymorphism ; Gene Therapy ; Genetic Predisposition to Disease - genetics ; Health risk assessment ; Heart diseases ; Human Genetics ; Humans ; Hyperplasia ; Hypertension ; Inheritance Patterns - genetics ; Large-Conductance Calcium-Activated Potassium Channel beta Subunits - genetics ; Molecular Medicine ; Mutation, Missense - genetics ; Myocardial Ischemia - genetics ; Polymorphism ; Risk factors ; Short Communication ; Spain</subject><ispartof>Journal of human genetics, 2005-11, Vol.50 (11), p.604-606</ispartof><rights>The Japan Society of Human Genetics and Springer-Verlag 2005</rights><rights>The Japan Society of Human Genetics and Springer-Verlag 2005.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-bbbcab7065d2897b7b22e37f10de270bf36c8a59f3821db196bd81d114f02ee83</citedby><cites>FETCH-LOGICAL-c437t-bbbcab7065d2897b7b22e37f10de270bf36c8a59f3821db196bd81d114f02ee83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10038-005-0298-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10038-005-0298-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16155733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Via, Marc</creatorcontrib><creatorcontrib>Valveny, Neus</creatorcontrib><creatorcontrib>López-Alomar, Antonio</creatorcontrib><creatorcontrib>Athanasiadis, Georgios</creatorcontrib><creatorcontrib>Pintó, Xavier</creatorcontrib><creatorcontrib>Domingo, Enric</creatorcontrib><creatorcontrib>Esteban, Esther</creatorcontrib><creatorcontrib>González-Pérez, Emili</creatorcontrib><creatorcontrib>Moral, Pedro</creatorcontrib><title>E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients</title><title>Journal of human genetics</title><addtitle>J Hum Genet</addtitle><addtitle>J Hum Genet</addtitle><description>Hypertension is a main risk factor for atherosclerosis through vascular wall hyperplasia. A recent study reported a new polymorphism (E65 K) in the β
1
subunit (KCNMB1) gene of the Ca
2+
-dependent potassium channel with a protective effect against the severity of diastolic hypertension, but further data have lead to conflicting results. In order to ascertain the involvement of the E65 K variant in cardiovascular system regulation, the potential association between this mutation and ischaemic heart disease was assessed through a family-based association study (
n
=302 individuals). Transmission disequilibrium analysis failed to detect any association between this polymorphism and ischaemic heart disease. Although a minor effect cannot be discarded, sample analytical power and negative results do not support a major role for E65 K polymorphism in atherogenic pathologies.</description><subject>Arteriosclerosis</subject><subject>Biomedicine</subject><subject>Calcium</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular system</subject><subject>Coronary artery disease</subject><subject>DNA Primers</subject><subject>Gene Expression</subject><subject>Gene Frequency</subject><subject>Gene Function</subject><subject>Gene polymorphism</subject><subject>Gene Therapy</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Health risk assessment</subject><subject>Heart diseases</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Hypertension</subject><subject>Inheritance Patterns - genetics</subject><subject>Large-Conductance Calcium-Activated Potassium Channel beta Subunits - genetics</subject><subject>Molecular Medicine</subject><subject>Mutation, Missense - genetics</subject><subject>Myocardial Ischemia - genetics</subject><subject>Polymorphism</subject><subject>Risk factors</subject><subject>Short Communication</subject><subject>Spain</subject><issn>1434-5161</issn><issn>1435-232X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kdtKHTEUhoMontoH6E0JCN6N5jA5zKVutIq2vbCF3oVkZo0T2XMwazbFt-mz9MnM7t4gFLxJwsr3_2uxfkI-cXbGGTPnmE9pC8ZUwURli2qHHPJSqkJI8Wv337ssFNf8gBwhPrFMCyP2yUEuKWWkPCRwpdXfP3d0Gpcv_ZimLmJP40DvFt--XnL6CAPQiHQYZ-oRxzr6GRr6O85dLtedhz7WtAOfZtpEBI-wVj9MfojY0cnPEYYZP5C91i8RPm7vY_Lz-urH4qa4__7ldnFxX9SlNHMRQqh9MEyrRtjKBBOEAGlazhoQhoVW6tp6VbXSCt4EXunQWN5wXrZMAFh5TE43vlMan1eAs-vzlLBc-gHGFTptrZZGiAye_Ac-jas05NmcKIXS2brUmeIbqk4jYoLWTSn2Pr04ztw6AbdJwOUE3DoBV2XN563zKvTQvCm2K8-A2ACYv4ZHSG-t33d9BeiVkM0</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Via, Marc</creator><creator>Valveny, Neus</creator><creator>López-Alomar, Antonio</creator><creator>Athanasiadis, Georgios</creator><creator>Pintó, Xavier</creator><creator>Domingo, Enric</creator><creator>Esteban, Esther</creator><creator>González-Pérez, Emili</creator><creator>Moral, Pedro</creator><general>Springer Japan</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients</title><author>Via, Marc ; Valveny, Neus ; López-Alomar, Antonio ; Athanasiadis, Georgios ; Pintó, Xavier ; Domingo, Enric ; Esteban, Esther ; González-Pérez, Emili ; Moral, Pedro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-bbbcab7065d2897b7b22e37f10de270bf36c8a59f3821db196bd81d114f02ee83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Arteriosclerosis</topic><topic>Biomedicine</topic><topic>Calcium</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular system</topic><topic>Coronary artery disease</topic><topic>DNA Primers</topic><topic>Gene Expression</topic><topic>Gene Frequency</topic><topic>Gene Function</topic><topic>Gene polymorphism</topic><topic>Gene Therapy</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Health risk assessment</topic><topic>Heart diseases</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Hypertension</topic><topic>Inheritance Patterns - genetics</topic><topic>Large-Conductance Calcium-Activated Potassium Channel beta Subunits - genetics</topic><topic>Molecular Medicine</topic><topic>Mutation, Missense - genetics</topic><topic>Myocardial Ischemia - genetics</topic><topic>Polymorphism</topic><topic>Risk factors</topic><topic>Short Communication</topic><topic>Spain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Via, Marc</creatorcontrib><creatorcontrib>Valveny, Neus</creatorcontrib><creatorcontrib>López-Alomar, Antonio</creatorcontrib><creatorcontrib>Athanasiadis, Georgios</creatorcontrib><creatorcontrib>Pintó, Xavier</creatorcontrib><creatorcontrib>Domingo, Enric</creatorcontrib><creatorcontrib>Esteban, Esther</creatorcontrib><creatorcontrib>González-Pérez, Emili</creatorcontrib><creatorcontrib>Moral, Pedro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Via, Marc</au><au>Valveny, Neus</au><au>López-Alomar, Antonio</au><au>Athanasiadis, Georgios</au><au>Pintó, Xavier</au><au>Domingo, Enric</au><au>Esteban, Esther</au><au>González-Pérez, Emili</au><au>Moral, Pedro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients</atitle><jtitle>Journal of human genetics</jtitle><stitle>J Hum Genet</stitle><addtitle>J Hum Genet</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>50</volume><issue>11</issue><spage>604</spage><epage>606</epage><pages>604-606</pages><issn>1434-5161</issn><eissn>1435-232X</eissn><abstract>Hypertension is a main risk factor for atherosclerosis through vascular wall hyperplasia. A recent study reported a new polymorphism (E65 K) in the β
1
subunit (KCNMB1) gene of the Ca
2+
-dependent potassium channel with a protective effect against the severity of diastolic hypertension, but further data have lead to conflicting results. In order to ascertain the involvement of the E65 K variant in cardiovascular system regulation, the potential association between this mutation and ischaemic heart disease was assessed through a family-based association study (
n
=302 individuals). Transmission disequilibrium analysis failed to detect any association between this polymorphism and ischaemic heart disease. Although a minor effect cannot be discarded, sample analytical power and negative results do not support a major role for E65 K polymorphism in atherogenic pathologies.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>16155733</pmid><doi>10.1007/s10038-005-0298-9</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of human genetics, 2005-11, Vol.50 (11), p.604-606 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Arteriosclerosis Biomedicine Calcium Cardiovascular disease Cardiovascular system Coronary artery disease DNA Primers Gene Expression Gene Frequency Gene Function Gene polymorphism Gene Therapy Genetic Predisposition to Disease - genetics Health risk assessment Heart diseases Human Genetics Humans Hyperplasia Hypertension Inheritance Patterns - genetics Large-Conductance Calcium-Activated Potassium Channel beta Subunits - genetics Molecular Medicine Mutation, Missense - genetics Myocardial Ischemia - genetics Polymorphism Risk factors Short Communication Spain |
| title | E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients |
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