Membrane curvature and mechanisms of dynamic cell membrane remodelling
Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking. Curvature can be dynamically modulated by changes in lipid composition, the oligomerization of curvature scaffolding pro...
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| Veröffentlicht in: | Nature 2005-12, Vol.438 (7068), p.590-596 |
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| creator | McMahon, Harvey T. Gallop, Jennifer L. |
| description | Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking. Curvature can be dynamically modulated by changes in lipid composition, the oligomerization of curvature scaffolding proteins and the reversible insertion of protein regions that act like wedges in membranes. There is an interplay between curvature-generating and curvature-sensing proteins during vesicle budding. This is seen during vesicle budding and in the formation of microenvironments. On a larger scale, membrane curvature is a prime player in growth, division and movement. |
| doi_str_mv | 10.1038/nature04396 |
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| subjects | Cell Membrane - chemistry Cell Membrane - metabolism Cellular biology Cytoskeleton - metabolism Humanities and Social Sciences Membrane Lipids - metabolism Membrane Proteins - chemistry Membrane Proteins - metabolism Membranes Microenvironments Microtubules - metabolism Molecular Motor Proteins - metabolism multidisciplinary Proteins review-article Science Science (multidisciplinary) |
| title | Membrane curvature and mechanisms of dynamic cell membrane remodelling |
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