Outcome and changes over time in survival following severe burns from 1985 to 2004
To investigate outcome in severely burned patients over a 20-year period and to evaluate survival over time. Historical cohort in a six-bed burn unit of a 1060-bed university hospital. 1385 patients admitted to the burn unit over a 20-year period. Outcome was evaluated in relation to the presence of...
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| Veröffentlicht in: | Intensive care medicine 2005-12, Vol.31 (12), p.1648-1653 |
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| creator | BRUSSELAERS, Nele HOSTE, Eric A. J MONSTREY, Stan COLPAERT, Kirsten E DE WAELE, Jan J VANDEWOUDE, Koenraad H BLOT, Stijn I |
| description | To investigate outcome in severely burned patients over a 20-year period and to evaluate survival over time.
Historical cohort in a six-bed burn unit of a 1060-bed university hospital.
1385 patients admitted to the burn unit over a 20-year period.
Outcome was evaluated in relation to the presence of three major risk factors for death: age 60 years or over, total burned surface area 40% or more, and the presence of inhalation injury. Overall mortality was 7.1%. When zero, one, two, or three risk factors were present, mortality was respectively 0.5%, 9.9%, 48.0%, and 90.5%. Over the study period the average proportional total burned surface area decreased as did mortality. The survival benefit was significant among patient groups with one or two risk factors present. Multivariate regression analysis adjusting for risk factors for death confirmed that survival improved over time (odds ratio 0.73 per 5-year period).
Global mortality following burns is low, and nearly all patients who die had at least one risk factor present. In the presence of three risk factors the prognosis following burns is particularly compromised. Taking into account that our patients over the past 20 years have been progressively less extensively burned and hence have a lesser at risk for death, survival following severe burns has continued to improve. |
| doi_str_mv | 10.1007/s00134-005-2819-6 |
| format | Article |
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Historical cohort in a six-bed burn unit of a 1060-bed university hospital.
1385 patients admitted to the burn unit over a 20-year period.
Outcome was evaluated in relation to the presence of three major risk factors for death: age 60 years or over, total burned surface area 40% or more, and the presence of inhalation injury. Overall mortality was 7.1%. When zero, one, two, or three risk factors were present, mortality was respectively 0.5%, 9.9%, 48.0%, and 90.5%. Over the study period the average proportional total burned surface area decreased as did mortality. The survival benefit was significant among patient groups with one or two risk factors present. Multivariate regression analysis adjusting for risk factors for death confirmed that survival improved over time (odds ratio 0.73 per 5-year period).
Global mortality following burns is low, and nearly all patients who die had at least one risk factor present. In the presence of three risk factors the prognosis following burns is particularly compromised. Taking into account that our patients over the past 20 years have been progressively less extensively burned and hence have a lesser at risk for death, survival following severe burns has continued to improve.</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/s00134-005-2819-6</identifier><identifier>PMID: 16220315</identifier><identifier>CODEN: ICMED9</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Belgium - epidemiology ; Biological and medical sciences ; Burns ; Burns - diagnosis ; Burns - mortality ; Burns - therapy ; Burns and scalds ; Care and treatment ; Case studies ; Child ; Child, Preschool ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Emergency and intensive care: burns ; Humans ; Infant ; Intensive care ; Intensive care medicine ; Logistic Models ; Medical prognosis ; Medical sciences ; Middle Aged ; Mortality ; Multivariate Analysis ; Patient outcomes ; Resuscitation ; Retrospective Studies ; Risk Factors ; ROC Curve ; Statistics ; Survival Rate - trends ; Trauma Severity Indices ; United States</subject><ispartof>Intensive care medicine, 2005-12, Vol.31 (12), p.1648-1653</ispartof><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2005 Springer</rights><rights>Springer-Verlag 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-1cc253d0e809254d76d99d3186ff6ecbb02075f28f255cc3ed440c92f91d410a3</citedby><cites>FETCH-LOGICAL-c461t-1cc253d0e809254d76d99d3186ff6ecbb02075f28f255cc3ed440c92f91d410a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17306962$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16220315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BRUSSELAERS, Nele</creatorcontrib><creatorcontrib>HOSTE, Eric A. J</creatorcontrib><creatorcontrib>MONSTREY, Stan</creatorcontrib><creatorcontrib>COLPAERT, Kirsten E</creatorcontrib><creatorcontrib>DE WAELE, Jan J</creatorcontrib><creatorcontrib>VANDEWOUDE, Koenraad H</creatorcontrib><creatorcontrib>BLOT, Stijn I</creatorcontrib><title>Outcome and changes over time in survival following severe burns from 1985 to 2004</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><description>To investigate outcome in severely burned patients over a 20-year period and to evaluate survival over time.
Historical cohort in a six-bed burn unit of a 1060-bed university hospital.
1385 patients admitted to the burn unit over a 20-year period.
Outcome was evaluated in relation to the presence of three major risk factors for death: age 60 years or over, total burned surface area 40% or more, and the presence of inhalation injury. Overall mortality was 7.1%. When zero, one, two, or three risk factors were present, mortality was respectively 0.5%, 9.9%, 48.0%, and 90.5%. Over the study period the average proportional total burned surface area decreased as did mortality. The survival benefit was significant among patient groups with one or two risk factors present. Multivariate regression analysis adjusting for risk factors for death confirmed that survival improved over time (odds ratio 0.73 per 5-year period).
Global mortality following burns is low, and nearly all patients who die had at least one risk factor present. In the presence of three risk factors the prognosis following burns is particularly compromised. Taking into account that our patients over the past 20 years have been progressively less extensively burned and hence have a lesser at risk for death, survival following severe burns has continued to improve.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Belgium - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Burns</subject><subject>Burns - diagnosis</subject><subject>Burns - mortality</subject><subject>Burns - therapy</subject><subject>Burns and scalds</subject><subject>Care and treatment</subject><subject>Case studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Emergency and intensive care: burns</subject><subject>Humans</subject><subject>Infant</subject><subject>Intensive care</subject><subject>Intensive care medicine</subject><subject>Logistic Models</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multivariate Analysis</subject><subject>Patient outcomes</subject><subject>Resuscitation</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Statistics</subject><subject>Survival Rate - trends</subject><subject>Trauma Severity Indices</subject><subject>United States</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpt0V1rFDEUBuAgit1Wf4A3EhS9m3pOvmZyWYpWoVAQvQ7ZTLJOmUlqMrPSf2-GXSjKkotAeN7DCS8hbxAuEaD9VACQiwZANqxD3ahnZIOCswYZ756TDXDBGqEEOyPnpdxX3SqJL8kZKsaAo9yQ73fL7NLkqY09db9s3PlC095nOg_1dYi0LHk_7O1IQxrH9GeIO1p8BZ5ulxwLDTlNFHUn6ZwoAxCvyItgx-JfH-8L8vPL5x_XX5vbu5tv11e3jRMK5wadY5L34DvQTIq-Vb3WPcdOhaC8226BQSsD6wKT0jnueyHAaRY09gLB8gvy8TD3Iaffiy-zmYbi_Dja6NNSjOo6hbwVFb77D96nunrdzTBUqFGKFb0_oJ0dvRliSHO2bp1orlBipzmHVTUn1M5Hn-2Yog9Dff7HX57w9fR-GtzJAB4CLqdSsg_mIQ-TzY8Gwaylm0PpppZu1tKNqpm3x_8t28n3T4ljyxV8OAJbnB1DttEN5cm1HJRWjP8FHyGvUw</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>BRUSSELAERS, Nele</creator><creator>HOSTE, Eric A. 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Coronary intensive care</topic><topic>Emergency and intensive care: burns</topic><topic>Humans</topic><topic>Infant</topic><topic>Intensive care</topic><topic>Intensive care medicine</topic><topic>Logistic Models</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multivariate Analysis</topic><topic>Patient outcomes</topic><topic>Resuscitation</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Statistics</topic><topic>Survival Rate - trends</topic><topic>Trauma Severity Indices</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BRUSSELAERS, Nele</creatorcontrib><creatorcontrib>HOSTE, Eric A. 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J</au><au>MONSTREY, Stan</au><au>COLPAERT, Kirsten E</au><au>DE WAELE, Jan J</au><au>VANDEWOUDE, Koenraad H</au><au>BLOT, Stijn I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcome and changes over time in survival following severe burns from 1985 to 2004</atitle><jtitle>Intensive care medicine</jtitle><addtitle>Intensive Care Med</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>31</volume><issue>12</issue><spage>1648</spage><epage>1653</epage><pages>1648-1653</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><coden>ICMED9</coden><abstract>To investigate outcome in severely burned patients over a 20-year period and to evaluate survival over time.
Historical cohort in a six-bed burn unit of a 1060-bed university hospital.
1385 patients admitted to the burn unit over a 20-year period.
Outcome was evaluated in relation to the presence of three major risk factors for death: age 60 years or over, total burned surface area 40% or more, and the presence of inhalation injury. Overall mortality was 7.1%. When zero, one, two, or three risk factors were present, mortality was respectively 0.5%, 9.9%, 48.0%, and 90.5%. Over the study period the average proportional total burned surface area decreased as did mortality. The survival benefit was significant among patient groups with one or two risk factors present. Multivariate regression analysis adjusting for risk factors for death confirmed that survival improved over time (odds ratio 0.73 per 5-year period).
Global mortality following burns is low, and nearly all patients who die had at least one risk factor present. In the presence of three risk factors the prognosis following burns is particularly compromised. Taking into account that our patients over the past 20 years have been progressively less extensively burned and hence have a lesser at risk for death, survival following severe burns has continued to improve.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>16220315</pmid><doi>10.1007/s00134-005-2819-6</doi><tpages>6</tpages></addata></record> |
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| ispartof | Intensive care medicine, 2005-12, Vol.31 (12), p.1648-1653 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Belgium - epidemiology Biological and medical sciences Burns Burns - diagnosis Burns - mortality Burns - therapy Burns and scalds Care and treatment Case studies Child Child, Preschool Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Emergency and intensive care: burns Humans Infant Intensive care Intensive care medicine Logistic Models Medical prognosis Medical sciences Middle Aged Mortality Multivariate Analysis Patient outcomes Resuscitation Retrospective Studies Risk Factors ROC Curve Statistics Survival Rate - trends Trauma Severity Indices United States |
| title | Outcome and changes over time in survival following severe burns from 1985 to 2004 |
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