Breast cancer–specific mortality after invasive local recurrence in patients with ductal carcinoma-in-situ of the breast
Previous studies on the efficacy of primary treatments for ductal carcinoma-in-situ (DCIS) have focused on local recurrence rates. Our objective was to detail the outcomes of local invasive recurrence, distant recurrence, and breast cancer mortality in patients previously treated for DCIS. Clinical,...
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| Veröffentlicht in: | The American journal of surgery 2006-10, Vol.192 (4), p.416-419 |
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| creator | Lee, Laura A. Silverstein, Melvin J. Chung, Cathie T. Macdonald, Heather Sanghavi, Premal Epstein, Melinda Holmes, Dennis R. Silberman, Howard Ye, Wei Lagios, Michael D. |
| description | Previous studies on the efficacy of primary treatments for ductal carcinoma-in-situ (DCIS) have focused on local recurrence rates. Our objective was to detail the outcomes of local invasive recurrence, distant recurrence, and breast cancer mortality in patients previously treated for DCIS.
Clinical, pathologic, and outcome data were collected prospectively for 1236 patients with pure DCIS accrued from 1972 through 2005.
There were 150 recurrences (87 DCIS and 63 invasive). Invasive local recurrence after mastectomy was rare (0.5% of patients) and after breast preservation was more frequent (12.0% of patients). The 12-year probabilities of breast cancer-specific mortality after mastectomy and after breast preservation were 0.8% and 1.0%, respectively. The 12-year breast cancer-specific mortality and distant disease probability for the 63 patients with invasive recurrences were 12% and 15%, respectively.
Regardless of initial treatment, most patients with invasive local recurrence after treatment for DCIS can be treated and cured. |
| doi_str_mv | 10.1016/j.amjsurg.2006.06.005 |
| format | Article |
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Clinical, pathologic, and outcome data were collected prospectively for 1236 patients with pure DCIS accrued from 1972 through 2005.
There were 150 recurrences (87 DCIS and 63 invasive). Invasive local recurrence after mastectomy was rare (0.5% of patients) and after breast preservation was more frequent (12.0% of patients). The 12-year probabilities of breast cancer-specific mortality after mastectomy and after breast preservation were 0.8% and 1.0%, respectively. The 12-year breast cancer-specific mortality and distant disease probability for the 63 patients with invasive recurrences were 12% and 15%, respectively.
Regardless of initial treatment, most patients with invasive local recurrence after treatment for DCIS can be treated and cured.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2006.06.005</identifier><identifier>PMID: 16978940</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Breast cancer ; Breast cancer mortality ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Cancer therapies ; Carcinoma, Intraductal, Noninfiltrating - mortality ; Carcinoma, Intraductal, Noninfiltrating - secondary ; Carcinoma, Intraductal, Noninfiltrating - surgery ; DCIS ; Disease-Free Survival ; Ductal carcinoma-in-situ ; Female ; Follow-Up Studies ; General aspects ; Gynecology. Andrology. Obstetrics ; Humans ; Local recurrence ; Mammary gland diseases ; Mammography ; Mastectomy ; Medical sciences ; Mortality ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; Patients ; Probability ; Prospective Studies ; Radiation therapy ; Survival Rate ; Therapy ; Treatment Outcome ; Tumors</subject><ispartof>The American journal of surgery, 2006-10, Vol.192 (4), p.416-419</ispartof><rights>2006 Excerpta Medica Inc.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Limited Oct 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-7cf4a3c24041235a7a024517d0e0d57a0b62797eb095ffe4f4ca505f223be2533</citedby><cites>FETCH-LOGICAL-c449t-7cf4a3c24041235a7a024517d0e0d57a0b62797eb095ffe4f4ca505f223be2533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002961006004478$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18225160$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16978940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Laura A.</creatorcontrib><creatorcontrib>Silverstein, Melvin J.</creatorcontrib><creatorcontrib>Chung, Cathie T.</creatorcontrib><creatorcontrib>Macdonald, Heather</creatorcontrib><creatorcontrib>Sanghavi, Premal</creatorcontrib><creatorcontrib>Epstein, Melinda</creatorcontrib><creatorcontrib>Holmes, Dennis R.</creatorcontrib><creatorcontrib>Silberman, Howard</creatorcontrib><creatorcontrib>Ye, Wei</creatorcontrib><creatorcontrib>Lagios, Michael D.</creatorcontrib><title>Breast cancer–specific mortality after invasive local recurrence in patients with ductal carcinoma-in-situ of the breast</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Previous studies on the efficacy of primary treatments for ductal carcinoma-in-situ (DCIS) have focused on local recurrence rates. Our objective was to detail the outcomes of local invasive recurrence, distant recurrence, and breast cancer mortality in patients previously treated for DCIS.
Clinical, pathologic, and outcome data were collected prospectively for 1236 patients with pure DCIS accrued from 1972 through 2005.
There were 150 recurrences (87 DCIS and 63 invasive). Invasive local recurrence after mastectomy was rare (0.5% of patients) and after breast preservation was more frequent (12.0% of patients). The 12-year probabilities of breast cancer-specific mortality after mastectomy and after breast preservation were 0.8% and 1.0%, respectively. The 12-year breast cancer-specific mortality and distant disease probability for the 63 patients with invasive recurrences were 12% and 15%, respectively.
Regardless of initial treatment, most patients with invasive local recurrence after treatment for DCIS can be treated and cured.</description><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast cancer mortality</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Cancer therapies</subject><subject>Carcinoma, Intraductal, Noninfiltrating - mortality</subject><subject>Carcinoma, Intraductal, Noninfiltrating - secondary</subject><subject>Carcinoma, Intraductal, Noninfiltrating - surgery</subject><subject>DCIS</subject><subject>Disease-Free Survival</subject><subject>Ductal carcinoma-in-situ</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Local recurrence</subject><subject>Mammary gland diseases</subject><subject>Mammography</subject><subject>Mastectomy</subject><subject>Medical sciences</subject><subject>Mortality</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Patients</subject><subject>Probability</subject><subject>Prospective Studies</subject><subject>Radiation therapy</subject><subject>Survival Rate</subject><subject>Therapy</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkd2K1TAQx4Mo7nH1EZSAuHc9TtIkba9El_UDFrzR65CmEzelH8ckPbJe-Q6-oU9i6ikseKEwEIb8ZvInP0KeMtgzYOplvzdjH5fwZc8B1H4tkPfIjtVVU7C6Lu-THQDwolEMzsijGPvcMibKh-SMqaaqGwE78v1NQBMTtWayGH79-BkPaL3zlo5zSGbw6ZYalzBQPx1N9Eekw2zNQAPaJQTMU_mGHkzyOKVIv_l0Q7vF5tG8M1g_zaMp_FREnxY6O5pukLZ_3nxMHjgzRHyynefk89urT5fvi-uP7z5cvr4urBBNKirrhCktFyAYL6WpDHAhWdUBQidz1ypeNRW20EjnUDhhjQTpOC9b5LIsz8nFae8hzF8XjEmPPlocBjPhvESt6lpB3cgMPv8L7OclTDmbZkIIxSrgzT8pKBlnijUqU_JE2TDHGNDpQ_CjCbcZ0qtA3etNoF4F6rVgzfBs2760I3Z3U5uxDLzYABOzBxeyOB_vuJpzydTKvTpxmL_26DHoaP2qq_NZXdLd7P8T5TeUW70Z</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Lee, Laura A.</creator><creator>Silverstein, Melvin J.</creator><creator>Chung, Cathie T.</creator><creator>Macdonald, Heather</creator><creator>Sanghavi, Premal</creator><creator>Epstein, Melinda</creator><creator>Holmes, Dennis R.</creator><creator>Silberman, Howard</creator><creator>Ye, Wei</creator><creator>Lagios, Michael D.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Breast cancer–specific mortality after invasive local recurrence in patients with ductal carcinoma-in-situ of the breast</title><author>Lee, Laura A. ; Silverstein, Melvin J. ; Chung, Cathie T. ; Macdonald, Heather ; Sanghavi, Premal ; Epstein, Melinda ; Holmes, Dennis R. ; Silberman, Howard ; Ye, Wei ; Lagios, Michael D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-7cf4a3c24041235a7a024517d0e0d57a0b62797eb095ffe4f4ca505f223be2533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast cancer mortality</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Cancer therapies</topic><topic>Carcinoma, Intraductal, Noninfiltrating - mortality</topic><topic>Carcinoma, Intraductal, Noninfiltrating - secondary</topic><topic>Carcinoma, Intraductal, Noninfiltrating - surgery</topic><topic>DCIS</topic><topic>Disease-Free Survival</topic><topic>Ductal carcinoma-in-situ</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Gynecology. Andrology. 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Our objective was to detail the outcomes of local invasive recurrence, distant recurrence, and breast cancer mortality in patients previously treated for DCIS.
Clinical, pathologic, and outcome data were collected prospectively for 1236 patients with pure DCIS accrued from 1972 through 2005.
There were 150 recurrences (87 DCIS and 63 invasive). Invasive local recurrence after mastectomy was rare (0.5% of patients) and after breast preservation was more frequent (12.0% of patients). The 12-year probabilities of breast cancer-specific mortality after mastectomy and after breast preservation were 0.8% and 1.0%, respectively. The 12-year breast cancer-specific mortality and distant disease probability for the 63 patients with invasive recurrences were 12% and 15%, respectively.
Regardless of initial treatment, most patients with invasive local recurrence after treatment for DCIS can be treated and cured.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16978940</pmid><doi>10.1016/j.amjsurg.2006.06.005</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biological and medical sciences Breast cancer Breast cancer mortality Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - surgery Cancer therapies Carcinoma, Intraductal, Noninfiltrating - mortality Carcinoma, Intraductal, Noninfiltrating - secondary Carcinoma, Intraductal, Noninfiltrating - surgery DCIS Disease-Free Survival Ductal carcinoma-in-situ Female Follow-Up Studies General aspects Gynecology. Andrology. Obstetrics Humans Local recurrence Mammary gland diseases Mammography Mastectomy Medical sciences Mortality Neoplasm Invasiveness Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Patients Probability Prospective Studies Radiation therapy Survival Rate Therapy Treatment Outcome Tumors |
| title | Breast cancer–specific mortality after invasive local recurrence in patients with ductal carcinoma-in-situ of the breast |
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