ADENOVIRUS-BASED TRANSIENT EXPRESSION SYSTEMS FOR PERITONEAL MEMBRANE RESEARCH
Scientific Affairs, 1 Renal Division, Baxter Healthcare Corporation, McGaw Park, Illinois, USA; Department of Medicine, 2 McMaster University and Division of Nephrology, St. Joseph's Hospital, Hamilton, Ontario, Canada Correspondence to: C.M. Hoff, Baxter Healthcare Corporation, Renal Division,...
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| Veröffentlicht in: | Peritoneal dialysis international 2006-09, Vol.26 (5), p.547-558 |
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| creator | Hoff, Catherine M Margetts, Peter J |
| description | Scientific Affairs, 1 Renal Division, Baxter
Healthcare Corporation, McGaw Park, Illinois, USA; Department of
Medicine, 2 McMaster University and Division of
Nephrology, St. Joseph's Hospital, Hamilton, Ontario, Canada
Correspondence to: C.M. Hoff, Baxter Healthcare Corporation, Renal Division,
1620 Waukegan Road, MPGR-A2N, McGaw Park, Illinois, 60085 USA.
Cathy_Hoff{at}baxter.com
Background: Peritoneal membrane research has provided
important insights into the physiology and pathophysiology of this tissue that
is of vital importance for peritoneal dialysis patients. Among the various
tools and methodologies used to study the peritoneum, we have extensively used
adenovirus-mediated gene transfer.
Methods: A literature review was carried out.
Information from reviewed papers was combined with the authors' experience and
results.
Results: We have used first-generation adenoviruses
that are simple to construct and can infect a wide range of dividing and
nondividing cell types. These vectors are restricted, however, in that they
provide only a short duration of transgene expression and may elicit an
inflammatory response. Modifications to this technology with helper-dependent
adenovirus may circumvent these problems but with increased complexity of
construction. Adenovirus-mediated gene transfer has been used to evaluate the
effect of several cytokines and growth factors on peritoneal membrane
physiology. We have used intraperitoneal delivery of transforming growth
factor-ß to generate an experimental model system of resolving peritoneal
fibrosis and epithelial mesenchymal transdifferentiation. We have studied the
effects of the inflammatory cytokines interleukin-1ß and tumor necrosis
factor alpha on the peritoneum, and have shown that antiangiogenic factors
such as sFLT-1 and angiostatin can reduce the damaging effects of exposure to
peritoneal dialysis solutions in an animal model.
Conclusions: The use of recombinant adenoviruses to
genetically modify cells and tissues is now a common laboratory research tool.
This technique has provided important advances in our understanding of the
peritoneal membrane.
KEY WORDS: Adenovirus; gene transfer; peritoneal membrane; peritoneal fibrosis; TGF-ß1; proinflammatory cytokines.
Received 24 January 2006;
accepted 6 June 2006. |
| doi_str_mv | 10.1177/089686080602600505 |
| format | Article |
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Healthcare Corporation, McGaw Park, Illinois, USA; Department of
Medicine, 2 McMaster University and Division of
Nephrology, St. Joseph's Hospital, Hamilton, Ontario, Canada
Correspondence to: C.M. Hoff, Baxter Healthcare Corporation, Renal Division,
1620 Waukegan Road, MPGR-A2N, McGaw Park, Illinois, 60085 USA.
Cathy_Hoff{at}baxter.com
Background: Peritoneal membrane research has provided
important insights into the physiology and pathophysiology of this tissue that
is of vital importance for peritoneal dialysis patients. Among the various
tools and methodologies used to study the peritoneum, we have extensively used
adenovirus-mediated gene transfer.
Methods: A literature review was carried out.
Information from reviewed papers was combined with the authors' experience and
results.
Results: We have used first-generation adenoviruses
that are simple to construct and can infect a wide range of dividing and
nondividing cell types. These vectors are restricted, however, in that they
provide only a short duration of transgene expression and may elicit an
inflammatory response. Modifications to this technology with helper-dependent
adenovirus may circumvent these problems but with increased complexity of
construction. Adenovirus-mediated gene transfer has been used to evaluate the
effect of several cytokines and growth factors on peritoneal membrane
physiology. We have used intraperitoneal delivery of transforming growth
factor-ß to generate an experimental model system of resolving peritoneal
fibrosis and epithelial mesenchymal transdifferentiation. We have studied the
effects of the inflammatory cytokines interleukin-1ß and tumor necrosis
factor alpha on the peritoneum, and have shown that antiangiogenic factors
such as sFLT-1 and angiostatin can reduce the damaging effects of exposure to
peritoneal dialysis solutions in an animal model.
Conclusions: The use of recombinant adenoviruses to
genetically modify cells and tissues is now a common laboratory research tool.
This technique has provided important advances in our understanding of the
peritoneal membrane.
KEY WORDS: Adenovirus; gene transfer; peritoneal membrane; peritoneal fibrosis; TGF-ß1; proinflammatory cytokines.
Received 24 January 2006;
accepted 6 June 2006.</description><identifier>ISSN: 0896-8608</identifier><identifier>EISSN: 1718-4304</identifier><identifier>DOI: 10.1177/089686080602600505</identifier><identifier>PMID: 16973508</identifier><language>eng</language><publisher>Milton, ON: Multimed</publisher><subject>Adenoviridae ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Cytokines - biosynthesis ; Dialysis Solutions - pharmacology ; Emergency and intensive care: renal failure. Dialysis management ; Fibrosis - etiology ; Fibrosis - metabolism ; Fibrosis - prevention & control ; Gene Transfer Techniques ; Genetic Vectors ; Glomerulonephritis ; Humans ; Intensive care medicine ; Medical sciences ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Peritoneal Dialysis - adverse effects ; Peritoneum - drug effects ; Peritoneum - metabolism ; Peritoneum - pathology ; Renal failure</subject><ispartof>Peritoneal dialysis international, 2006-09, Vol.26 (5), p.547-558</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-91a1c3ef1f00e624f6be6b62570e20925b406b178f4656e8538c2cc555267b8d3</citedby><cites>FETCH-LOGICAL-c405t-91a1c3ef1f00e624f6be6b62570e20925b406b178f4656e8538c2cc555267b8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18194062$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16973508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoff, Catherine M</creatorcontrib><creatorcontrib>Margetts, Peter J</creatorcontrib><title>ADENOVIRUS-BASED TRANSIENT EXPRESSION SYSTEMS FOR PERITONEAL MEMBRANE RESEARCH</title><title>Peritoneal dialysis international</title><addtitle>Perit Dial Int</addtitle><description>Scientific Affairs, 1 Renal Division, Baxter
Healthcare Corporation, McGaw Park, Illinois, USA; Department of
Medicine, 2 McMaster University and Division of
Nephrology, St. Joseph's Hospital, Hamilton, Ontario, Canada
Correspondence to: C.M. Hoff, Baxter Healthcare Corporation, Renal Division,
1620 Waukegan Road, MPGR-A2N, McGaw Park, Illinois, 60085 USA.
Cathy_Hoff{at}baxter.com
Background: Peritoneal membrane research has provided
important insights into the physiology and pathophysiology of this tissue that
is of vital importance for peritoneal dialysis patients. Among the various
tools and methodologies used to study the peritoneum, we have extensively used
adenovirus-mediated gene transfer.
Methods: A literature review was carried out.
Information from reviewed papers was combined with the authors' experience and
results.
Results: We have used first-generation adenoviruses
that are simple to construct and can infect a wide range of dividing and
nondividing cell types. These vectors are restricted, however, in that they
provide only a short duration of transgene expression and may elicit an
inflammatory response. Modifications to this technology with helper-dependent
adenovirus may circumvent these problems but with increased complexity of
construction. Adenovirus-mediated gene transfer has been used to evaluate the
effect of several cytokines and growth factors on peritoneal membrane
physiology. We have used intraperitoneal delivery of transforming growth
factor-ß to generate an experimental model system of resolving peritoneal
fibrosis and epithelial mesenchymal transdifferentiation. We have studied the
effects of the inflammatory cytokines interleukin-1ß and tumor necrosis
factor alpha on the peritoneum, and have shown that antiangiogenic factors
such as sFLT-1 and angiostatin can reduce the damaging effects of exposure to
peritoneal dialysis solutions in an animal model.
Conclusions: The use of recombinant adenoviruses to
genetically modify cells and tissues is now a common laboratory research tool.
This technique has provided important advances in our understanding of the
peritoneal membrane.
KEY WORDS: Adenovirus; gene transfer; peritoneal membrane; peritoneal fibrosis; TGF-ß1; proinflammatory cytokines.
Received 24 January 2006;
accepted 6 June 2006.</description><subject>Adenoviridae</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cytokines - biosynthesis</subject><subject>Dialysis Solutions - pharmacology</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Fibrosis - etiology</subject><subject>Fibrosis - metabolism</subject><subject>Fibrosis - prevention & control</subject><subject>Gene Transfer Techniques</subject><subject>Genetic Vectors</subject><subject>Glomerulonephritis</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Peritoneal Dialysis - adverse effects</subject><subject>Peritoneum - drug effects</subject><subject>Peritoneum - metabolism</subject><subject>Peritoneum - pathology</subject><subject>Renal failure</subject><issn>0896-8608</issn><issn>1718-4304</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0EtPg0AUBeCJ0dj6-AMuDBvdoXcG5sES26mStGCAGl1NYDpYDH3ItGn899LYpAtXd_Pdk5yD0A2GB4w5fwQRMMFAAAPCACjQE9THHAvX98A_Rf09cPeihy6s_QLwiAf8HPUwC7hHQfRRHA5lnLxF6TRzn8JMDp08DeMsknHuyPfXVGZZlMRO9pHlcpI5oyR1XmUa5Uksw7EzkZOnjkunczJMBy9X6KwqGmuuD_cSTUcyH7y44-Q5GoRjV_tAN26AC6w9U-EKwDDiV6w0rGSEcjAEAkJLH1iJuah8RpkR1BOaaE0pJYyXYuZdovu_3HW7-t4au1GL2mrTNMXSrLZWMdHVxpR2kPxB3a6sbU2l1m29KNofhUHtV1T_V-yebg_p23JhZseXw2wduDuAwuqiqdpiqWt7dAIHXQFydPP6c76rW6PsomiaLpao3W5HmKKK-tz7BRzkfks</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Hoff, Catherine M</creator><creator>Margetts, Peter J</creator><general>Multimed</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>ADENOVIRUS-BASED TRANSIENT EXPRESSION SYSTEMS FOR PERITONEAL MEMBRANE RESEARCH</title><author>Hoff, Catherine M ; Margetts, Peter J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-91a1c3ef1f00e624f6be6b62570e20925b406b178f4656e8538c2cc555267b8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenoviridae</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cytokines - biosynthesis</topic><topic>Dialysis Solutions - pharmacology</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Fibrosis - etiology</topic><topic>Fibrosis - metabolism</topic><topic>Fibrosis - prevention & control</topic><topic>Gene Transfer Techniques</topic><topic>Genetic Vectors</topic><topic>Glomerulonephritis</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Peritoneal Dialysis - adverse effects</topic><topic>Peritoneum - drug effects</topic><topic>Peritoneum - metabolism</topic><topic>Peritoneum - pathology</topic><topic>Renal failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoff, Catherine M</creatorcontrib><creatorcontrib>Margetts, Peter J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peritoneal dialysis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoff, Catherine M</au><au>Margetts, Peter J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ADENOVIRUS-BASED TRANSIENT EXPRESSION SYSTEMS FOR PERITONEAL MEMBRANE RESEARCH</atitle><jtitle>Peritoneal dialysis international</jtitle><addtitle>Perit Dial Int</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>26</volume><issue>5</issue><spage>547</spage><epage>558</epage><pages>547-558</pages><issn>0896-8608</issn><eissn>1718-4304</eissn><abstract>Scientific Affairs, 1 Renal Division, Baxter
Healthcare Corporation, McGaw Park, Illinois, USA; Department of
Medicine, 2 McMaster University and Division of
Nephrology, St. Joseph's Hospital, Hamilton, Ontario, Canada
Correspondence to: C.M. Hoff, Baxter Healthcare Corporation, Renal Division,
1620 Waukegan Road, MPGR-A2N, McGaw Park, Illinois, 60085 USA.
Cathy_Hoff{at}baxter.com
Background: Peritoneal membrane research has provided
important insights into the physiology and pathophysiology of this tissue that
is of vital importance for peritoneal dialysis patients. Among the various
tools and methodologies used to study the peritoneum, we have extensively used
adenovirus-mediated gene transfer.
Methods: A literature review was carried out.
Information from reviewed papers was combined with the authors' experience and
results.
Results: We have used first-generation adenoviruses
that are simple to construct and can infect a wide range of dividing and
nondividing cell types. These vectors are restricted, however, in that they
provide only a short duration of transgene expression and may elicit an
inflammatory response. Modifications to this technology with helper-dependent
adenovirus may circumvent these problems but with increased complexity of
construction. Adenovirus-mediated gene transfer has been used to evaluate the
effect of several cytokines and growth factors on peritoneal membrane
physiology. We have used intraperitoneal delivery of transforming growth
factor-ß to generate an experimental model system of resolving peritoneal
fibrosis and epithelial mesenchymal transdifferentiation. We have studied the
effects of the inflammatory cytokines interleukin-1ß and tumor necrosis
factor alpha on the peritoneum, and have shown that antiangiogenic factors
such as sFLT-1 and angiostatin can reduce the damaging effects of exposure to
peritoneal dialysis solutions in an animal model.
Conclusions: The use of recombinant adenoviruses to
genetically modify cells and tissues is now a common laboratory research tool.
This technique has provided important advances in our understanding of the
peritoneal membrane.
KEY WORDS: Adenovirus; gene transfer; peritoneal membrane; peritoneal fibrosis; TGF-ß1; proinflammatory cytokines.
Received 24 January 2006;
accepted 6 June 2006.</abstract><cop>Milton, ON</cop><pub>Multimed</pub><pmid>16973508</pmid><doi>10.1177/089686080602600505</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Peritoneal dialysis international, 2006-09, Vol.26 (5), p.547-558 |
| issn | 0896-8608 1718-4304 |
| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Adenoviridae Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Cytokines - biosynthesis Dialysis Solutions - pharmacology Emergency and intensive care: renal failure. Dialysis management Fibrosis - etiology Fibrosis - metabolism Fibrosis - prevention & control Gene Transfer Techniques Genetic Vectors Glomerulonephritis Humans Intensive care medicine Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Peritoneal Dialysis - adverse effects Peritoneum - drug effects Peritoneum - metabolism Peritoneum - pathology Renal failure |
| title | ADENOVIRUS-BASED TRANSIENT EXPRESSION SYSTEMS FOR PERITONEAL MEMBRANE RESEARCH |
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