Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

Transforming growth factor-β (TGF-β) has been implicated in the control of differentiation and proliferation of multiple cell types. However, a role for TGF-β in the control of immune homeostasis is not fully understood because of its pleiotropic action. Here we report that complete ablation of the...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2006-09, Vol.25 (3), p.441-454
Hauptverfasser:	Marie, Julien C., Liggitt, Denny, Rudensky, Alexander Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Surface - metabolism Autoimmune Diseases - genetics Autoimmune Diseases - metabolism Autoimmune Diseases - mortality CELLIMMUNO Cells, Cultured DEVBIO Immune Tolerance - genetics Lectins, C-Type - metabolism Lymphocyte Depletion Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic NK Cell Lectin-Like Receptor Subfamily B Receptors, Transforming Growth Factor beta - deficiency Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - physiology T-Lymphocytes - immunology T-Lymphocytes - metabolism Time Factors
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