Timing of critical genetic changes in human breast disease

Breast cancer development has been characterized as a nonobligatory sequence of histological changes from normal epithelium through invasive malignancy. Although genetic alterations are thought to accumulate stochastically during tumorigenesis, little is known about the timing of critical mutations....

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Veröffentlicht in:	Annals of surgical oncology 2005-12, Vol.12 (12), p.1054-1060
Hauptverfasser:	Ellsworth, Rachel E, Ellsworth, Darrell L, Deyarmin, Brenda, Hoffman, Laurel R, Love, Brad, Hooke, Jeffrey A, Shriver, Craig D
Format:	Artikel
Sprache:	eng
Schlagworte:	Allelic Imbalance Breast - metabolism Breast - pathology Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma, Ductal, Breast - genetics Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Lobular - genetics Disease Progression Genomic Instability Humans Hyperplasia Immunohistochemistry Microsatellite Repeats
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