dUbc9 negatively regulates the Toll-NF-κB pathways in larval hematopoiesis and drosomycin activation in Drosophila

Highly conserved during evolution, the enzyme Ubc9 activates the small ubiquitin-like modifier (SUMO) prior to its covalent ligation to target proteins. We have used mutations in the Drosophila Ubc9 ( dUbc9) gene to understand Ubc9 functions in vivo. Loss-of-function mutations in dUbc9 cause strong...

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