Complex Modulation of Cell Type-Specific Signaling in Response to Type I Interferons
The type I interferons (IFNs) are pleiotropic cytokines that regulate many different cellular functions. The major signaling pathway activated by type I IFNs involves sequential phosphorylation of the tyrosine residues of the Janus kinase (JAK) and signal transducers and activators of transcription...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2006-09, Vol.25 (3), p.361-372 |
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| creator | van Boxel-Dezaire, Anette H.H. Rani, M.R. Sandhya Stark, George R. |
| description | The type I interferons (IFNs) are pleiotropic cytokines that regulate many different cellular functions. The major signaling pathway activated by type I IFNs involves sequential phosphorylation of the tyrosine residues of the Janus kinase (JAK) and signal transducers and activators of transcription (STAT) proteins, providing the primary mechanism through which gene expression is induced. Recent work has shown that the responses are quite complex, as shown by different responses to specific subtypes of type I IFN, activation of kinases in addition to JAKs, patterns of activation of all seven STATs in different cells, and activation of transcription factors other than STATs. The type I IFNs use this complexity to regulate many different biological functions in different types of cells, by activating different specific signals and patterns of gene expression. |
| doi_str_mv | 10.1016/j.immuni.2006.08.014 |
| format | Article |
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Sandhya</creatorcontrib><creatorcontrib>Stark, George R.</creatorcontrib><title>Complex Modulation of Cell Type-Specific Signaling in Response to Type I Interferons</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>The type I interferons (IFNs) are pleiotropic cytokines that regulate many different cellular functions. The major signaling pathway activated by type I IFNs involves sequential phosphorylation of the tyrosine residues of the Janus kinase (JAK) and signal transducers and activators of transcription (STAT) proteins, providing the primary mechanism through which gene expression is induced. Recent work has shown that the responses are quite complex, as shown by different responses to specific subtypes of type I IFN, activation of kinases in addition to JAKs, patterns of activation of all seven STATs in different cells, and activation of transcription factors other than STATs. 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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Blood Cells - enzymology Blood Cells - immunology Blood Cells - metabolism Gene expression Humans Immune system Interferon Interferon Type I - metabolism Interferon Type I - physiology Kinases Ligands Phosphorylation Proteins Signal Transduction - genetics Signal Transduction - immunology STAT Transcription Factors - metabolism STAT Transcription Factors - physiology Transcription factors |
| title | Complex Modulation of Cell Type-Specific Signaling in Response to Type I Interferons |
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