Presence of preserved reactive germinal centers in follicular lymphoma is a strong histopathologic indicator of limited disease stage

Follicular lymphoma (FL) typically presents as a systemic disease (stages III/IV). We repeatedly observed in cases with conserved reactive follicle structures (so-called partial infiltration) an association with a limited clinical stage (I/II). In this study, we analyzed 53 lymph node biopsies of FL...

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Veröffentlicht in:	The American journal of surgical pathology 2005-12, Vol.29 (12), p.1661-1664
Hauptverfasser:	Adam, Patrick, Katzenberger, Tiemo, Eifert, Miriam, Ott, M Michaela, Rosenwald, Andreas, Müller-Hermelink, Hans Konrad, Ott, German
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Biopsy Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 18 Diagnosis, Differential Female Germinal Center - metabolism Germinal Center - pathology Histocytochemistry Hodgkin Disease - diagnosis Hodgkin Disease - genetics Hodgkin Disease - metabolism Hodgkin Disease - pathology Humans Immunoglobulin G - metabolism Immunohistochemistry In Situ Hybridization, Fluorescence Lymph Nodes - pathology Lymphoma, Follicular - diagnosis Lymphoma, Follicular - genetics Lymphoma, Follicular - metabolism Lymphoma, Follicular - pathology Male Middle Aged Neoplasm Staging - statistics & numerical data Proto-Oncogene Proteins c-bcl-2 - metabolism Retrospective Studies Translocation, Genetic
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