Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cells

BACKGROUND: Most alloantigens on transfused red blood cells (RBCs) are weakly immunogenic, with only a 2 to 6 percent overall immunization rate even in patients receiving multiple transfusions. Although recipient genetics may contribute to responder and/or nonresponder status, in most cases HLA type...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2006-09, Vol.46 (9), p.1526-1536
Hauptverfasser:	Hendrickson, Jeanne E., Desmarets, Maxime, Deshpande, Seema S., Chadwick, Traci E., Hillyer, Christopher D., Roback, John D., Zimring, James C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antibody Formation Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bone marrow, stem cells transplantation. Graft versus host reaction Crosses, Genetic Erythrocyte Transfusion Erythrocytes - immunology Hematology Immunization Immunoglobulin G - blood Inflammation - etiology Inflammation - immunology Inflammation - physiopathology Investigative techniques, diagnostic techniques (general aspects) Isoantigens - immunology Leukocyte Reduction Procedures Medical sciences Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Transgenic Models, Animal Muramidase - administration & dosage Muramidase - genetics Muramidase - immunology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Poly I-C - pharmacology Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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