Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs

The mechanism of action of chemotherapeutic drugs and their ability to induce multidrug resistance (MDR) are of relevance to cancer treatment. Overexpression of P-glycoprotein (Pgp) encoded by the MDR1 gene following chemotherapy can severely limit the efficacy of anticancer agents; however, the man...

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Veröffentlicht in:	Oncogene 2005-12, Vol.24 (54), p.8061-8075
Hauptverfasser:	Baker, Emma K, Johnstone, Ricky W, Zalcberg, John R, El-Osta, Assam
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Antineoplastic Agents - pharmacology Antitumor agents Apoptosis ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Cancer therapies Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chemotherapy Chromatin - metabolism Chromatin Immunoprecipitation Chromatin. Chromosome CpG islands CpG Islands - drug effects DNA methylation DNA Methylation - drug effects Drug Resistance, Multiple Drug Resistance, Neoplasm Drugs Epigenesis, Genetic - drug effects Epigenetics Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene Silencing Genes, MDR - drug effects Glycoproteins Histones Histones - metabolism Human Genetics Humans Internal Medicine MDR1 protein Medical research Medicine Medicine & Public Health Molecular and cellular biology Molecular genetics Multidrug resistance Multidrug resistant organisms Neoplasms - drug therapy Neoplasms - physiopathology Oncology original-paper P-Glycoprotein Patients Phenotypes Post-transcription Promoter Regions, Genetic - drug effects Protein Processing, Post-Translational Remission (Medicine) Transcription activation Transcriptional Activation - drug effects Up-Regulation
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