An RNA gene expressed during cortical development evolved rapidly in humans

The developmental and evolutionary mechanisms behind the emergence of human-specific brain features remain largely unknown. However, the recent ability to compare our genome to that of our closest relative, the chimpanzee, provides new avenues to link genetic and phenotypic changes in the evolution...

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Veröffentlicht in:	Nature 2006-09, Vol.443 (7108), p.167-172
Hauptverfasser:	Pollard, Katherine S., Salama, Sofie R., Lambert, Nelle, Lambot, Marie-Alexandra, Coppens, Sandra, Pedersen, Jakob S., Katzman, Sol, King, Bryan, Onodera, Courtney, Siepel, Adam, Kern, Andrew D., Dehay, Colette, Igel, Haller, Ares, Manuel, Vanderhaeghen, Pierre, Haussler, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Animals Base Sequence Biological and medical sciences Biological evolution Brain Cell Adhesion Molecules, Neuronal - genetics Cell differentiation, maturation, development, hematopoiesis Cell physiology Cerebral Cortex - anatomy & histology Cerebral Cortex - embryology Cerebral Cortex - metabolism Evolution, Molecular Evolutionary biology Extracellular Matrix Proteins - genetics Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Expression Regulation, Developmental Genetics of eukaryotes. Biological and molecular evolution Genomics Genotype & phenotype Humanities and Social Sciences Humans Macaca - genetics Molecular and cellular biology Molecular Sequence Data multidisciplinary Mutation - genetics Neocortex - anatomy & histology Neocortex - embryology Neocortex - metabolism Nerve Tissue Proteins - genetics Neurosciences Nucleic Acid Conformation Organ Specificity Pan troglodytes Prenatal development Reelin Protein RNA Stability RNA, Untranslated - chemistry RNA, Untranslated - genetics RNA, Untranslated - metabolism Science Science (multidisciplinary) Serine Endopeptidases - genetics Time Factors
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