Investigation of penetratin peptides. Part 2. In vitro uptake of penetratin and two of its derivatives

As endocytic uptake of the Antennapedia homeodomain‐derived penetratin peptide (RQIKIWFQNRRMKWKK) is finally being revealed, some of the early views about penetratin need to be reconsidered. Endocytic uptake seems to contradict the indispensability of tryptophans and also the minimum length of 16 am...

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Veröffentlicht in:	Journal of peptide science 2005-12, Vol.11 (12), p.805-811
Hauptverfasser:	Letoha, Tamás, Gaál, Szilvia, Somlai, Csaba, Venkei, Zsolt, Glavinas, Hristos, Kusz, Erzsébet, Duda, Ernö, Czajlik, András, Peták, Ferenc, Penke, Botond
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Animals beta-Cyclodextrins - pharmacology Carrier Proteins - metabolism Cell Line Cell Membrane Permeability cell-penetrating peptides Cholesterol - metabolism confocal microscopy Endocytosis FITC-labeling Flow Cytometry Heparitin Sulfate - pharmacology Humans lipid rafts Membrane Microdomains - physiology Mice Microscopy, Confocal Molecular Sequence Data penetratin Peptide Fragments - metabolism
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