N-Terminal Pro-Brain Natriuretic Peptide Levels Are Elevated in Patients with Acute Ischemic Stroke
Brain natriuretic peptide (BNP) is a counterregulatory hormone released by the ventricles of the heart. Its main actions are natriuresis and vasodilation. The authors studied N-terminal pro-brain natriuretic peptide (NT-proBNP) levels soon after an acute ischemic stroke. They compared plasma NT-proB...
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| Veröffentlicht in: | Angiology 2005-11, Vol.56 (6), p.723-730 |
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| creator | Giannakoulas, George Hatzitolios, Apostolos Karvounis, Haralambos Koliakos, George Charitandi, Aphrodite Dimitroulas, Theodoros Savopoulos, Christos Tsirogianni, Efrosini Louridas, George |
| description | Brain natriuretic peptide (BNP) is a counterregulatory hormone released by the ventricles of the heart. Its main actions are natriuresis and vasodilation. The authors studied N-terminal pro-brain natriuretic peptide (NT-proBNP) levels soon after an acute ischemic stroke. They compared plasma NT-proBNP concentrations in 30 patients with an acute ischemic stroke with those of 30 controls. The 2 groups were adjusted for age and gender, and there were no significant differences in vascular risk factors and left ventricular systolic and diastolic function. Venous samples were collected within the first 11.8 ±1.2 hours after the onset of symptoms and again on day 6. Brain computed tomography/magnetic resonance imaging (CT/MRI) was performed on the same days (day 0 and day 6) in order to assess the site (carotid or vertebrobasilar), cause (atherothrombotic, cardioembolic, or lacunar), and size (large, medium, or small) of the brain infarct. NT-proBNP levels were elevated in patients with acute stroke (129.9 ±9.9 fmol/mL) compared with the controls (90.8 ±6.3 fmol/mL, p |
| doi_str_mv | 10.1177/000331970505600610 |
| format | Article |
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Its main actions are natriuresis and vasodilation. The authors studied N-terminal pro-brain natriuretic peptide (NT-proBNP) levels soon after an acute ischemic stroke. They compared plasma NT-proBNP concentrations in 30 patients with an acute ischemic stroke with those of 30 controls. The 2 groups were adjusted for age and gender, and there were no significant differences in vascular risk factors and left ventricular systolic and diastolic function. Venous samples were collected within the first 11.8 ±1.2 hours after the onset of symptoms and again on day 6. Brain computed tomography/magnetic resonance imaging (CT/MRI) was performed on the same days (day 0 and day 6) in order to assess the site (carotid or vertebrobasilar), cause (atherothrombotic, cardioembolic, or lacunar), and size (large, medium, or small) of the brain infarct. NT-proBNP levels were elevated in patients with acute stroke (129.9 ±9.9 fmol/mL) compared with the controls (90.8 ±6.3 fmol/mL, p<0.05). These levels remained elevated at day 6 (113.5 ±13.0 fmol/mL). NT-proBNP at admission was significantly higher in cardioembolic compared with atherothrombotic infarctions. There was no correlation between circulating NT-proBNP and stroke topography, infarct size, or severity as assessed by the National Institutes of Health Stroke Scale (NIHSS) at any of the 2 time points (admission and day 6). NT-proBNP levels were raised in patients with acute ischemic stroke; this effect persisted until day 6. The authors suggest that neurohumoral activation occurs in patients with acute ischemic stroke, either reflecting a counterbalancing vasodilating response to the cerebral ischemia or direct myocardial dysfunction.</description><identifier>ISSN: 0003-3197</identifier><identifier>EISSN: 1940-1574</identifier><identifier>DOI: 10.1177/000331970505600610</identifier><identifier>PMID: 16327949</identifier><identifier>CODEN: ANGIAB</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Aged ; Biological and medical sciences ; Blood and lymphatic vessels ; Brain Ischemia - blood ; Brain Ischemia - complications ; Brain Ischemia - pathology ; Cardiology. Vascular system ; Case-Control Studies ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Natriuretic Peptide, Brain - blood ; Neurology ; Neuropharmacology ; Neuroprotective agent ; Peptide Fragments - blood ; Pharmacology. Drug treatments ; Risk Factors ; Severity of Illness Index ; Stroke - blood ; Stroke - etiology ; Stroke - pathology ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Angiology, 2005-11, Vol.56 (6), p.723-730</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-72beba5ce2ddab96c515f5441403cc7fe86bd93df2254e46b9e69914b3f721a3</citedby><cites>FETCH-LOGICAL-c402t-72beba5ce2ddab96c515f5441403cc7fe86bd93df2254e46b9e69914b3f721a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/000331970505600610$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/000331970505600610$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17352995$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16327949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giannakoulas, George</creatorcontrib><creatorcontrib>Hatzitolios, Apostolos</creatorcontrib><creatorcontrib>Karvounis, Haralambos</creatorcontrib><creatorcontrib>Koliakos, George</creatorcontrib><creatorcontrib>Charitandi, Aphrodite</creatorcontrib><creatorcontrib>Dimitroulas, Theodoros</creatorcontrib><creatorcontrib>Savopoulos, Christos</creatorcontrib><creatorcontrib>Tsirogianni, Efrosini</creatorcontrib><creatorcontrib>Louridas, George</creatorcontrib><title>N-Terminal Pro-Brain Natriuretic Peptide Levels Are Elevated in Patients with Acute Ischemic Stroke</title><title>Angiology</title><addtitle>Angiology</addtitle><description>Brain natriuretic peptide (BNP) is a counterregulatory hormone released by the ventricles of the heart. Its main actions are natriuresis and vasodilation. The authors studied N-terminal pro-brain natriuretic peptide (NT-proBNP) levels soon after an acute ischemic stroke. They compared plasma NT-proBNP concentrations in 30 patients with an acute ischemic stroke with those of 30 controls. The 2 groups were adjusted for age and gender, and there were no significant differences in vascular risk factors and left ventricular systolic and diastolic function. Venous samples were collected within the first 11.8 ±1.2 hours after the onset of symptoms and again on day 6. Brain computed tomography/magnetic resonance imaging (CT/MRI) was performed on the same days (day 0 and day 6) in order to assess the site (carotid or vertebrobasilar), cause (atherothrombotic, cardioembolic, or lacunar), and size (large, medium, or small) of the brain infarct. NT-proBNP levels were elevated in patients with acute stroke (129.9 ±9.9 fmol/mL) compared with the controls (90.8 ±6.3 fmol/mL, p<0.05). These levels remained elevated at day 6 (113.5 ±13.0 fmol/mL). NT-proBNP at admission was significantly higher in cardioembolic compared with atherothrombotic infarctions. There was no correlation between circulating NT-proBNP and stroke topography, infarct size, or severity as assessed by the National Institutes of Health Stroke Scale (NIHSS) at any of the 2 time points (admission and day 6). NT-proBNP levels were raised in patients with acute ischemic stroke; this effect persisted until day 6. The authors suggest that neurohumoral activation occurs in patients with acute ischemic stroke, either reflecting a counterbalancing vasodilating response to the cerebral ischemia or direct myocardial dysfunction.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Brain Ischemia - blood</subject><subject>Brain Ischemia - complications</subject><subject>Brain Ischemia - pathology</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Neuroprotective agent</subject><subject>Peptide Fragments - blood</subject><subject>Pharmacology. Drug treatments</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Stroke - blood</subject><subject>Stroke - etiology</subject><subject>Stroke - pathology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0003-3197</issn><issn>1940-1574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctKAzEUBuAgitbLC7iQbHQ3mmRyaZa11AuUWrD7IZM5o9G51CRT8e2d0koXgq5C4PtPwvkROqfkmlKlbgghaUq1IoIISYikZA8NqOYkoULxfTRYg2QtjtBxCG_9VVAiD9ERlSlTmusBsrNkAb52janw3LfJrTeuwTMTves8RGfxHJbRFYCnsIIq4JEHPKlgZSIUuKdzEx00MeBPF1_xyHYR8GOwr1D32efo23c4RQelqQKcbc8TtLibLMYPyfTp_nE8miaWExYTxXLIjbDAisLkWlpBRSk4p5yk1qoShjIvdFqUjAkOXOYapNaU52mpGDXpCbrajF369qODELPaBQtVZRpou5DJ4VAwrcW_kBEyZP1Ke8g20Po2BA9ltvSuNv4royRbV5D9rqAPXWynd3kNxS6y3XkPLrfABGuq0pvGurBzKv355s3GBfMC2Vvb-b6k8NfT35Qgmsc</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Giannakoulas, George</creator><creator>Hatzitolios, Apostolos</creator><creator>Karvounis, Haralambos</creator><creator>Koliakos, George</creator><creator>Charitandi, Aphrodite</creator><creator>Dimitroulas, Theodoros</creator><creator>Savopoulos, Christos</creator><creator>Tsirogianni, Efrosini</creator><creator>Louridas, George</creator><general>SAGE Publications</general><general>Westminster</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>N-Terminal Pro-Brain Natriuretic Peptide Levels Are Elevated in Patients with Acute Ischemic Stroke</title><author>Giannakoulas, George ; Hatzitolios, Apostolos ; Karvounis, Haralambos ; Koliakos, George ; Charitandi, Aphrodite ; Dimitroulas, Theodoros ; Savopoulos, Christos ; Tsirogianni, Efrosini ; Louridas, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-72beba5ce2ddab96c515f5441403cc7fe86bd93df2254e46b9e69914b3f721a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Brain Ischemia - blood</topic><topic>Brain Ischemia - complications</topic><topic>Brain Ischemia - pathology</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Neuroprotective agent</topic><topic>Peptide Fragments - blood</topic><topic>Pharmacology. Drug treatments</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Stroke - blood</topic><topic>Stroke - etiology</topic><topic>Stroke - pathology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giannakoulas, George</creatorcontrib><creatorcontrib>Hatzitolios, Apostolos</creatorcontrib><creatorcontrib>Karvounis, Haralambos</creatorcontrib><creatorcontrib>Koliakos, George</creatorcontrib><creatorcontrib>Charitandi, Aphrodite</creatorcontrib><creatorcontrib>Dimitroulas, Theodoros</creatorcontrib><creatorcontrib>Savopoulos, Christos</creatorcontrib><creatorcontrib>Tsirogianni, Efrosini</creatorcontrib><creatorcontrib>Louridas, George</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Angiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giannakoulas, George</au><au>Hatzitolios, Apostolos</au><au>Karvounis, Haralambos</au><au>Koliakos, George</au><au>Charitandi, Aphrodite</au><au>Dimitroulas, Theodoros</au><au>Savopoulos, Christos</au><au>Tsirogianni, Efrosini</au><au>Louridas, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-Terminal Pro-Brain Natriuretic Peptide Levels Are Elevated in Patients with Acute Ischemic Stroke</atitle><jtitle>Angiology</jtitle><addtitle>Angiology</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>56</volume><issue>6</issue><spage>723</spage><epage>730</epage><pages>723-730</pages><issn>0003-3197</issn><eissn>1940-1574</eissn><coden>ANGIAB</coden><abstract>Brain natriuretic peptide (BNP) is a counterregulatory hormone released by the ventricles of the heart. Its main actions are natriuresis and vasodilation. The authors studied N-terminal pro-brain natriuretic peptide (NT-proBNP) levels soon after an acute ischemic stroke. They compared plasma NT-proBNP concentrations in 30 patients with an acute ischemic stroke with those of 30 controls. The 2 groups were adjusted for age and gender, and there were no significant differences in vascular risk factors and left ventricular systolic and diastolic function. Venous samples were collected within the first 11.8 ±1.2 hours after the onset of symptoms and again on day 6. Brain computed tomography/magnetic resonance imaging (CT/MRI) was performed on the same days (day 0 and day 6) in order to assess the site (carotid or vertebrobasilar), cause (atherothrombotic, cardioembolic, or lacunar), and size (large, medium, or small) of the brain infarct. NT-proBNP levels were elevated in patients with acute stroke (129.9 ±9.9 fmol/mL) compared with the controls (90.8 ±6.3 fmol/mL, p<0.05). These levels remained elevated at day 6 (113.5 ±13.0 fmol/mL). NT-proBNP at admission was significantly higher in cardioembolic compared with atherothrombotic infarctions. There was no correlation between circulating NT-proBNP and stroke topography, infarct size, or severity as assessed by the National Institutes of Health Stroke Scale (NIHSS) at any of the 2 time points (admission and day 6). NT-proBNP levels were raised in patients with acute ischemic stroke; this effect persisted until day 6. The authors suggest that neurohumoral activation occurs in patients with acute ischemic stroke, either reflecting a counterbalancing vasodilating response to the cerebral ischemia or direct myocardial dysfunction.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>16327949</pmid><doi>10.1177/000331970505600610</doi><tpages>8</tpages></addata></record> |
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| ispartof | Angiology, 2005-11, Vol.56 (6), p.723-730 |
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| subjects | Aged Biological and medical sciences Blood and lymphatic vessels Brain Ischemia - blood Brain Ischemia - complications Brain Ischemia - pathology Cardiology. Vascular system Case-Control Studies Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Follow-Up Studies Humans Male Medical sciences Natriuretic Peptide, Brain - blood Neurology Neuropharmacology Neuroprotective agent Peptide Fragments - blood Pharmacology. Drug treatments Risk Factors Severity of Illness Index Stroke - blood Stroke - etiology Stroke - pathology Vascular diseases and vascular malformations of the nervous system |
| title | N-Terminal Pro-Brain Natriuretic Peptide Levels Are Elevated in Patients with Acute Ischemic Stroke |
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