Stimulus intensity and coil characteristics influence the efficacy of rTMS to suppress cortical excitability
Low-frequency repetitive transcranial magnetic stimulation (rTMS) can reduce cortical excitability. Here we examined whether inhibitory after effects of low-frequency rTMS are influenced by stimulus intensity, the type of TMS coil and re-afferent sensory stimulation. In fifteen healthy volunteers, w...
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| Veröffentlicht in: | Clinical neurophysiology 2006-10, Vol.117 (10), p.2292-2301 |
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| creator | Lang, Nicolas Harms, Jochen Weyh, Thomas Lemon, Roger N. Paulus, Walter Rothwell, John C. Siebner, Hartwig R. |
| description | Low-frequency repetitive transcranial magnetic stimulation (rTMS) can reduce cortical excitability. Here we examined whether inhibitory after effects of low-frequency rTMS are influenced by stimulus intensity, the type of TMS coil and re-afferent sensory stimulation.
In fifteen healthy volunteers, we applied 900 biphasic pulses of 1
Hz rTMS to the left primary motor cortex (M1) at an intensity that was 10% below or 15% above resting motor threshold. For rTMS, we used two different figure-of-eight shaped coils (Magstim or Medtronic coil) attached to the same stimulator. We recorded motor evoked potentials (MEPs) evoked with the same set-up used for rTMS (MEP-rTMS) before and twice after rTMS. Using a different TMS setup, we also applied monophasic pulses to the M1 in order to assess the effects of rTMS on corticospinal excitability, intracortical paired-pulse excitability and the duration of the cortical silent period (CSP). In a control experiment, the same measurements were performed after 15
min of 1
Hz repetitive electrical nerve stimulation (rENS) of the right ulnar nerve.
Analysis of variance revealed an interaction between intensity, coil and time of measurement (
p
<
0.035), indicating that the effect of 1
Hz rTMS on MEP-rTMS amplitude depended on the intensity and the type of coil used for rTMS. Suppression of corticospinal excitability was strongest after suprathreshold 1
Hz rTMS with the Medtronic coil (
p
<
0.01 for both post-rTMS measurements relative to pre-intervention baseline). Regardless of the type of coil, suprathreshold but not subthreshold rTMS transiently prolonged the CSP and attenuated paired-pulse facilitation. Suprathreshold 1
Hz rENS also induced a short-lasting inhibition of MEP-rTMS.
Both the stimulation intensity and the type of TMS coil have an impact on the after effects of 1
Hz rTMS. Re-afferent feedback activation may at least in part account for the stronger suppression of corticospinal excitability by suprathreshold 1
Hz rTMS.
These data should be considered when rTMS is used as a therapeutic means. |
| doi_str_mv | 10.1016/j.clinph.2006.05.030 |
| format | Article |
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In fifteen healthy volunteers, we applied 900 biphasic pulses of 1
Hz rTMS to the left primary motor cortex (M1) at an intensity that was 10% below or 15% above resting motor threshold. For rTMS, we used two different figure-of-eight shaped coils (Magstim or Medtronic coil) attached to the same stimulator. We recorded motor evoked potentials (MEPs) evoked with the same set-up used for rTMS (MEP-rTMS) before and twice after rTMS. Using a different TMS setup, we also applied monophasic pulses to the M1 in order to assess the effects of rTMS on corticospinal excitability, intracortical paired-pulse excitability and the duration of the cortical silent period (CSP). In a control experiment, the same measurements were performed after 15
min of 1
Hz repetitive electrical nerve stimulation (rENS) of the right ulnar nerve.
Analysis of variance revealed an interaction between intensity, coil and time of measurement (
p
<
0.035), indicating that the effect of 1
Hz rTMS on MEP-rTMS amplitude depended on the intensity and the type of coil used for rTMS. Suppression of corticospinal excitability was strongest after suprathreshold 1
Hz rTMS with the Medtronic coil (
p
<
0.01 for both post-rTMS measurements relative to pre-intervention baseline). Regardless of the type of coil, suprathreshold but not subthreshold rTMS transiently prolonged the CSP and attenuated paired-pulse facilitation. Suprathreshold 1
Hz rENS also induced a short-lasting inhibition of MEP-rTMS.
Both the stimulation intensity and the type of TMS coil have an impact on the after effects of 1
Hz rTMS. Re-afferent feedback activation may at least in part account for the stronger suppression of corticospinal excitability by suprathreshold 1
Hz rTMS.
These data should be considered when rTMS is used as a therapeutic means.</description><identifier>ISSN: 1388-2457</identifier><identifier>EISSN: 1872-8952</identifier><identifier>DOI: 10.1016/j.clinph.2006.05.030</identifier><identifier>PMID: 16920022</identifier><language>eng</language><publisher>Oxford: Elsevier Ireland Ltd</publisher><subject>Adaptation, Physiological - physiology ; Adult ; Biological and medical sciences ; Cerebral Cortex - physiology ; Coil characteristic ; Corticospinal excitability ; Electrical nerve stimulation ; Electrodiagnosis. Electric activity recording ; Evoked Potentials, Motor - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Motor cortex ; Nervous system ; Neural Inhibition - physiology ; Repetitive transcranial magnetic stimulation (rTMS) ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Stimulus intensity ; Transcranial Magnetic Stimulation - instrumentation ; Transcranial Magnetic Stimulation - methods ; Vertebrates: nervous system and sense organs</subject><ispartof>Clinical neurophysiology, 2006-10, Vol.117 (10), p.2292-2301</ispartof><rights>2006 International Federation of Clinical Neurophysiology</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-472cea159989ded0fca26696f19321da88e620d1c917251630b7d268489a3f413</citedby><cites>FETCH-LOGICAL-c456t-472cea159989ded0fca26696f19321da88e620d1c917251630b7d268489a3f413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinph.2006.05.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25991141$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16920022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lang, Nicolas</creatorcontrib><creatorcontrib>Harms, Jochen</creatorcontrib><creatorcontrib>Weyh, Thomas</creatorcontrib><creatorcontrib>Lemon, Roger N.</creatorcontrib><creatorcontrib>Paulus, Walter</creatorcontrib><creatorcontrib>Rothwell, John C.</creatorcontrib><creatorcontrib>Siebner, Hartwig R.</creatorcontrib><title>Stimulus intensity and coil characteristics influence the efficacy of rTMS to suppress cortical excitability</title><title>Clinical neurophysiology</title><addtitle>Clin Neurophysiol</addtitle><description>Low-frequency repetitive transcranial magnetic stimulation (rTMS) can reduce cortical excitability. Here we examined whether inhibitory after effects of low-frequency rTMS are influenced by stimulus intensity, the type of TMS coil and re-afferent sensory stimulation.
In fifteen healthy volunteers, we applied 900 biphasic pulses of 1
Hz rTMS to the left primary motor cortex (M1) at an intensity that was 10% below or 15% above resting motor threshold. For rTMS, we used two different figure-of-eight shaped coils (Magstim or Medtronic coil) attached to the same stimulator. We recorded motor evoked potentials (MEPs) evoked with the same set-up used for rTMS (MEP-rTMS) before and twice after rTMS. Using a different TMS setup, we also applied monophasic pulses to the M1 in order to assess the effects of rTMS on corticospinal excitability, intracortical paired-pulse excitability and the duration of the cortical silent period (CSP). In a control experiment, the same measurements were performed after 15
min of 1
Hz repetitive electrical nerve stimulation (rENS) of the right ulnar nerve.
Analysis of variance revealed an interaction between intensity, coil and time of measurement (
p
<
0.035), indicating that the effect of 1
Hz rTMS on MEP-rTMS amplitude depended on the intensity and the type of coil used for rTMS. Suppression of corticospinal excitability was strongest after suprathreshold 1
Hz rTMS with the Medtronic coil (
p
<
0.01 for both post-rTMS measurements relative to pre-intervention baseline). Regardless of the type of coil, suprathreshold but not subthreshold rTMS transiently prolonged the CSP and attenuated paired-pulse facilitation. Suprathreshold 1
Hz rENS also induced a short-lasting inhibition of MEP-rTMS.
Both the stimulation intensity and the type of TMS coil have an impact on the after effects of 1
Hz rTMS. Re-afferent feedback activation may at least in part account for the stronger suppression of corticospinal excitability by suprathreshold 1
Hz rTMS.
These data should be considered when rTMS is used as a therapeutic means.</description><subject>Adaptation, Physiological - physiology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cerebral Cortex - physiology</subject><subject>Coil characteristic</subject><subject>Corticospinal excitability</subject><subject>Electrical nerve stimulation</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Evoked Potentials, Motor - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor cortex</subject><subject>Nervous system</subject><subject>Neural Inhibition - physiology</subject><subject>Repetitive transcranial magnetic stimulation (rTMS)</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Stimulus intensity</subject><subject>Transcranial Magnetic Stimulation - instrumentation</subject><subject>Transcranial Magnetic Stimulation - methods</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>1388-2457</issn><issn>1872-8952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1ERUvhHyDkC9yS2k7i2BckVPElFfXQcra847HWK28SbAex_75edgU3TjOH53018xDyhrOWMy5vdi3EMC3bVjAmWza0rGPPyBVXo2iUHsTzundKNaIfxkvyMucdY2xkvXhBLrnUNSXEFYkPJezXuGYapoJTDuVA7eQozCFS2NpkoWAKuQQ4Ij6uOAHSskWK3gewcKCzp-nx-wMtM83rsiTMueZTjdhI8TeEYjch1uZX5MLbmPH1eV6TH58_Pd5-be7uv3y7_XjXQD_I0vSjALR80Fpph455sEJKLT3XneDOKoVSMMdB81EMXHZsMzohVa-07XzPu2vy_tS7pPnnirmYfciAMdoJ5zUbqdTAmVYV7E8gpDnnhN4sKextOhjOzNGy2ZmTZXO0bNhgquUae3vuXzd7dP9CZ60VeHcGbK4SfLIThPyXE_U1zv8c-uHEYbXxK2AyGcJRsAsJoRg3h_9f8gQyFJ3r</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Lang, Nicolas</creator><creator>Harms, Jochen</creator><creator>Weyh, Thomas</creator><creator>Lemon, Roger N.</creator><creator>Paulus, Walter</creator><creator>Rothwell, John C.</creator><creator>Siebner, Hartwig R.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Stimulus intensity and coil characteristics influence the efficacy of rTMS to suppress cortical excitability</title><author>Lang, Nicolas ; Harms, Jochen ; Weyh, Thomas ; Lemon, Roger N. ; Paulus, Walter ; Rothwell, John C. ; Siebner, Hartwig R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-472cea159989ded0fca26696f19321da88e620d1c917251630b7d268489a3f413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adaptation, Physiological - physiology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cerebral Cortex - physiology</topic><topic>Coil characteristic</topic><topic>Corticospinal excitability</topic><topic>Electrical nerve stimulation</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Evoked Potentials, Motor - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor cortex</topic><topic>Nervous system</topic><topic>Neural Inhibition - physiology</topic><topic>Repetitive transcranial magnetic stimulation (rTMS)</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Stimulus intensity</topic><topic>Transcranial Magnetic Stimulation - instrumentation</topic><topic>Transcranial Magnetic Stimulation - methods</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lang, Nicolas</creatorcontrib><creatorcontrib>Harms, Jochen</creatorcontrib><creatorcontrib>Weyh, Thomas</creatorcontrib><creatorcontrib>Lemon, Roger N.</creatorcontrib><creatorcontrib>Paulus, Walter</creatorcontrib><creatorcontrib>Rothwell, John C.</creatorcontrib><creatorcontrib>Siebner, Hartwig R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lang, Nicolas</au><au>Harms, Jochen</au><au>Weyh, Thomas</au><au>Lemon, Roger N.</au><au>Paulus, Walter</au><au>Rothwell, John C.</au><au>Siebner, Hartwig R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimulus intensity and coil characteristics influence the efficacy of rTMS to suppress cortical excitability</atitle><jtitle>Clinical neurophysiology</jtitle><addtitle>Clin Neurophysiol</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>117</volume><issue>10</issue><spage>2292</spage><epage>2301</epage><pages>2292-2301</pages><issn>1388-2457</issn><eissn>1872-8952</eissn><abstract>Low-frequency repetitive transcranial magnetic stimulation (rTMS) can reduce cortical excitability. Here we examined whether inhibitory after effects of low-frequency rTMS are influenced by stimulus intensity, the type of TMS coil and re-afferent sensory stimulation.
In fifteen healthy volunteers, we applied 900 biphasic pulses of 1
Hz rTMS to the left primary motor cortex (M1) at an intensity that was 10% below or 15% above resting motor threshold. For rTMS, we used two different figure-of-eight shaped coils (Magstim or Medtronic coil) attached to the same stimulator. We recorded motor evoked potentials (MEPs) evoked with the same set-up used for rTMS (MEP-rTMS) before and twice after rTMS. Using a different TMS setup, we also applied monophasic pulses to the M1 in order to assess the effects of rTMS on corticospinal excitability, intracortical paired-pulse excitability and the duration of the cortical silent period (CSP). In a control experiment, the same measurements were performed after 15
min of 1
Hz repetitive electrical nerve stimulation (rENS) of the right ulnar nerve.
Analysis of variance revealed an interaction between intensity, coil and time of measurement (
p
<
0.035), indicating that the effect of 1
Hz rTMS on MEP-rTMS amplitude depended on the intensity and the type of coil used for rTMS. Suppression of corticospinal excitability was strongest after suprathreshold 1
Hz rTMS with the Medtronic coil (
p
<
0.01 for both post-rTMS measurements relative to pre-intervention baseline). Regardless of the type of coil, suprathreshold but not subthreshold rTMS transiently prolonged the CSP and attenuated paired-pulse facilitation. Suprathreshold 1
Hz rENS also induced a short-lasting inhibition of MEP-rTMS.
Both the stimulation intensity and the type of TMS coil have an impact on the after effects of 1
Hz rTMS. Re-afferent feedback activation may at least in part account for the stronger suppression of corticospinal excitability by suprathreshold 1
Hz rTMS.
These data should be considered when rTMS is used as a therapeutic means.</abstract><cop>Oxford</cop><pub>Elsevier Ireland Ltd</pub><pmid>16920022</pmid><doi>10.1016/j.clinph.2006.05.030</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adaptation, Physiological - physiology Adult Biological and medical sciences Cerebral Cortex - physiology Coil characteristic Corticospinal excitability Electrical nerve stimulation Electrodiagnosis. Electric activity recording Evoked Potentials, Motor - physiology Female Fundamental and applied biological sciences. Psychology Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Motor cortex Nervous system Neural Inhibition - physiology Repetitive transcranial magnetic stimulation (rTMS) Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Stimulus intensity Transcranial Magnetic Stimulation - instrumentation Transcranial Magnetic Stimulation - methods Vertebrates: nervous system and sense organs |
| title | Stimulus intensity and coil characteristics influence the efficacy of rTMS to suppress cortical excitability |
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